A major goal of viral oncotherapy – the use of viruses to destroy tumors – is to design viruses that kill tumor cells but not normal cells. Two adenoviruses provide perfect examples of how this specificity can be achieved.
Adenovirus CG0070, designed to treat bladder cancer, and adenovirus O... Read More
A new study delineates a sequential pattern of changes in the intestinal microbial population of patients recovering from cholera in Bangladesh, findings that may point to ways of speeding recovery from the dangerous diarrheal disease. The report also finds what appear to be consistent differenc... Read More
I am a big believer that different pedagogical approaches can "reach" different students. In most of my classes, I give students an optional assignment: come up with a creative project that explores some aspect of class. This takes several steps. First, I make the students come up with an ide... Read More
Rhinovirus is the most frequent cause of the common cold, and the virus itself is quite common: there are over 160 types, classified into 3 species. The cell receptor has just been identified for the rhinovirus C species, which can cause more severe illness than members of the A or B species: it... Read More
Scientists from the University of Queensland and a biotechnology company discovered a new class of antibiotics, which is a kind of synthetic sugar. And the new antibiotics can significantly decrease the drug resistance caused by bacteria, and kill them. These new antibiotics can be a powerful dr... Read More
Throat swab of (5) years old child from emergency department for culture and sensitivity clinical summary scarlet fever.
Streptococcus pyogenes, or Group A Streptococcus, is a spherical, Gram-positive bacterium. S. pyogenes displays streptococcal group A antigen on its cell wall and typic... Read More
If the reader does not believe that viroids and satellites are distinctive, then surely prions, infectious agents composed only of protein, must impress.
The question of whether infectious agents exist without genomes arose with the discovery and characterization of infectious agents associat... Read More
The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon was found to contaminate other cell lines. Now HeLa RNA has made its way into human sequence dat... Read More
A Geosmin Story:
A Musty / Muddy smell - the earthy odour after a heavy spatter of rain is aesthetic to senses.
A poet sitting in such ambiance lets his thoughts to wander randomly and comes out with a sweet piece of write up.
An Artist can do wonders on his canvas flowing with the mood.
Man... Read More
About eight percent of human DNA is viral: it consists of retroviral genomes produced by infections that occurred many years ago. These endogenous retroviruses are passed from parent to child in our DNA. Some of these viral genomes are activated for a brief time during human embryogenesis, sugge... Read More
Mineral coatings on sand particles actually encourage microbial activity in the rapid sand filters that are used to treat groundwater for drinking, according to a paper published ahead of print in Applied and Environmental Microbiology. These findings resoundingly refute, for the first time, the... Read More
Immunology Explained Through Poetry - What happens when one touches a poison ivy?
Billy was at summer camp,
And wanted to feel like a champ,
So he searched for a flower,
That would stop Susie’s glower,
But found poison ivy instead.
While Billy was later playing,
He had no i... Read More
As far as I know, mosquitoes do not eat sushi. But mosquito cells have proteins with sushi repeat domains, and these proteins protect the brain from lethal virus infections. Read More
The general program for the 2015 American Society of Microbiology meeting in New Orleans is out, and registration is now open. The sessions look incredible, and I've listed them below as I imagine they might resonate with many of the readers of this blog. The bolded sessions look particularly in... Read More
Recovering viral genomes from ancient specimens can provide information about viral evolution, but not many old nucleic acids have been identified. A study of 700 year old caribou feces reveals that viruses can be protected for long periods of time – under the right conditions. Read More
Animal associated S. aureus are distinct from human strains but some recent studies suggested the human infection caused by animal origin strain of MRSA. Extensive and unregulated use of antibiotic in animal husbandry might be one of the causes for development of multidrug resistant strain. Tran... Read More
A permissive vaccine prevents disease in the immunized host, but does not block virus infection. Would a permissive vaccine lead to the emergence of more virulent viruses?
This hypothesis is based on the notion that viruses which kill their hosts too quickly are not efficiently transmitted, a... Read More
Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also have gastrointestinal symptoms such as vomiting and diarrhea. In mice, intestinal injury occurs in the absence of viral replication, and is a consequence of viral depletion of the gut... Read More
The great folks at "The People Behind the Science" interviewed me over Skype in late July, and the interview has just been released as a podcast. I discuss my path through science, my thoughts on teaching, research at undergraduate institution, and how to motivate and inspire students to strive... Read More
Follow the reconstruction and simulation of poliovirus using the BlueGene/Q supercomputer at the Victorian Life Sciences Computation Initiative. The poliovirus model is being used as a basis for understanding antiviral drugs, virus infection and helps us to learn how to model related viruses suc... Read More