In episode #3 of the new science show This Week in Evolution, Nels and Vincent examine another important driver of evolution: recombination. The results of two papers in which the process is studied in finches and in yeast lead to the unexpected conclusion that recombination evolves more slowly ... Read More
One of the most dangerous places for an infection to occur is in the bloodstream. Septicemia, when microbes are present in the blood, not only allows bacteria access to other internal organs through the highway of our circulatory system, but also can cause a massive inflammatory response, leadin... Read More
The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella.
The molecular order of events is important in virulence, and a new paper published in the Journal of Bacteriology looks at the order of events necessary for bacterial toxin delivery to a host cell. Specifically, the authors looked at the assembly of Shiga toxin, produced by Shigella dysenteriae ... Read More
It has been speculated that the development of neurological disease and fetal abnormalities after Zika virus infection may be due to the presence of antibodies against other flaviruses that enhance disease. In support of this hypothesis, it has been shown that antibodies to dengue virus enhance... Read More
The rapid spread of Zika virus through the Americas, together with the association of infection with microcephaly and Guillain-Barré syndrome, have propelled this previously ignored virus into the limelight. What is this virus and where did it come from?
Polio returns to Nigeria after two years - but it turns out it had never gone away.
Amidst the fear surrounding Zika virus, remember that there are over 100,000 children born each year with birth defects caused by infection with rubella virus.
Rubella virus is a member of the Togaviridae family, which also includes chikungunya virus. The genome is a 9.7 kilobase, positive st... Read More
The previous post mentioned the onset of antibiotic resistance as one of the scarier, if less sensationalist, outbreaks of our time. We generally discuss antibiotic resistance in medically relevant microbes (on this blog and in the news), where resistance means the ability of disease-causing mic... Read More
If it looks like a duck and quacks like a duck, it’s likely a duck – so goes the saying that illustrates the simplest explanation is usually the right one. But what about duck decoys used in conjunction with bird calls? Misidentification can be a deadly error – and the same goes for microbes. Mi... Read More
"Hivi and his team of viruses (Ebola, Pox,..etc) believe they can win the battle, but the Virologists (who are real famous professors) beat them. However, new viruses pop-up, it will be a long battle. This makes the story very interesting and ever so engaging."
ACKNOWLEDGMEN... Read More
In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.
Host: Read More
Because of its safety, efficacy, and affordability, chloroquine remains the treatment of choice for all Plasmodium species, except in regions with chloroquine-resistant P. falciparum. Chloroquine-resistant protists are treated with combination therapy, which includes artemisinin-derived molecule... Read More
We’ve previously covered the importance of diagnostics in disease control and treatment. This is vital to controlling disease progression and transmission, but epidemiology studies can’t always show how a disease progresses or transmits. This is where scientists need a well-characterized animal ... Read More
Host: Jeff Fox with special guests, Carolyn Shore and Ruben Tommasi.
Carolyn Shore of Pew Charitable Trusts in Washington, D.C., and Ruben Tommasi of Entasis Therapeutics in Waltham, Massachusetts, talk with Jeff Fox about what’s needed to identify and develop new antimicrobial agents... Read More
Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More
How does a single-celled organism ‘know’ how to respond to its environmental conditions? Understanding microbial cell signaling is one way to determine how bacteria will react in a particular setting. In the past decade, researchers have revealed a significant role for cyclic-di-GMP in bacterial... Read More
Host: Jeff Fox with special guests, Ron Milo and Shai Fuchs.
Ron Milo of Weizmann Institute of Science in Rehovot, Israel, and Shai Fuchs at the Hospital for Sick Children in Toronto, Canada, talk with Jeff Fox about their efforts, with Ron Sender at Weizmann, to redetermine the ratio... Read More
Dr. Michael Diamond, 2016 Elizabeth O. King Lecturer, has worked for the past two decades investigating how viruses work, with a goal of defining basic principles of pathogenesis and host immune restriction. His talk in this podcast focuses on how his laboratory has studied three emerging mos... Read More