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A WORD on the constraints of influenza virus evolution

Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza vir... Read More

To combat the overuse of antibacterials, stop using the absolutely terrible word, "antibiotic"

There are many reasons why bacteria evolve resistance to antibacterials, but one of the preventable reasons is the over-prescription of antibacterials to patients who don't have bacterial infections. But how to get people to stop asking for antibacterials? My suggestion is to stop using the wor... Read More

TWiV 295: A nonslip grippe and Lassa's LAMP

The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.


Hosts: Vincent Racaniello,&n... Read More

The Science Behind Honey’s Eternal Shelf Life

Modern archeologists, excavating ancient Egyptian tombs, have often found something unexpected amongst the tombs’ artifacts: pots of honey, thousands of years old, and yet still preserved. Through millennia, the archeologists discover, the food remains unspoiled, an unmistakable testament to the... Read More

Bespoke microbiome therapy to manage plant diseases

In this paper we describe the perspective of following the achievements in medicine, where gut microbiome transplants are proving to be a powerful method to overcome several gastrointestinal disorders and many other physiological problems, to possible solve diseases in plants. There is strong si... Read More

On a Cellular Level, We Are ALL Overachievers!

In this blog post, I show a science-cartoon by the great "Beatrice the Biologist" that illustrates an important point in my freshman introductory cell and molecular biology course: no matter how tired we might be, we are incredibly busy on a cellular level! Beatrice is a fine artist who underst... Read More

BacterioFiles Micro Edition 147 - Clostridium Conquers Colleagues

This episode: Non-pathogenic Clostridium difficile strains can protect hamsters against their disease-causing bacterial siblings!


(7 MB, 7.5 minutes)


When hamsters were colonized with toxin-free strains of C. difficile, they were better able to resist infection b... Read More

Creative "Extra Credit" Projects in Microbiology!

In this blog entry, I explore how students can use their creativity to learn microbiology in innovative and often artistic ways. It makes learning more personal! Read More

TWiV 282: Tamiflu and tenure too




Hosts:  Read More

Freshman Biology Creative Projects!

I have found that students become involved, energized, and enthusiastic when I give them opportunities to explore topics in my classes using their own creative approaches and interests. So this semester, in my Biology 111 course at the University of Puget Sound, I found that students explored f... Read More

Evidence-based antibiotic usage

New recommendation encourages physicians to prescribe _antibacterials_ instead of antibiotics for bacterial infections. This recommendation is based on compelling evidence that the word "antibiotic" confuses almost everyone, including some doctors. The confusion leads to strong patient demands... Read More

TWiM 83 Letters

Matt writes:


Hello TWiM team,

It was great seeing some of you at ASM last week in Boston either in passing between sessions or at the live TWiV episode. I have a few questions about the ASM meeting:
What was something that you all took away from ASM th... Read More

Microbe/Mineral Affinities

This is a paper from the Geomicrobiology lab at the Jackson School of Geosciences at the University of Texas at Austin. It was recently published in a special issue of Geomicrobiology Journal focused on geomicrobiology of subsurface microorganisms in cave environments.

In this study we attemp... Read More

Using Wordcloud-Reponses to Discover How Students Perceive Concepts in the Classroom

In this blog, I share some "first word that comes to mind" responses of my freshman biology class to the words "germ," "bacteria," "cell," and "DNA." The way that we perceive an idea or concept definitely impacts our relationship with it. Thus, finding out what students think, coming into our ... Read More

TWiV 301: Marine viruses and insect defense

At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.


Host:  Read More

Fouchier vs the Dutch government on influenza H5N1 research

Readers of this blog will remember the furor sparked by Fouchier’s experiments in 2011 in which he developed an avian influenza H5N1 isolate that could transmit among ferrets by aerosol. When Fouchier was ready to publish the results, the Dutch government required that Fouchier apply for an expo... Read More

TWiP 71 letters


Heather writes:


Hi Dr.s R&D,


I thought you might be interested in this news article about aquaculture in Hong Kong. Perhaps it's time for another fish parasite episode? I love the podcast, keep up the great work.


Heather


Bill writes: Read More

BacterioFiles 180 - Phage Functions Fight Fortifications

This episode: Some phages can fight back against bacterial defenses with recently discovered genes!


(8.3 MB, 9 minutes)


Show notes: 
Journal Paper Read More

Hepatitis B viruses in bats

Hepatitis B virus (HBV, illustrated) is a substantial human pathogen. WHO estimates that there are now 240,000,000 individuals chronically infected with HBV worldwide, of which 25% will die from chronic liver disease or hepatocellular carcinoma. The hepatitis B virus vaccine is highly effective ... Read More

TWiV 289: Vinny and the capsids

Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.


Hosts:  Read More

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