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Clostridium difficile in the domicile

Patients undergoing FMT have often suffered for years prior to the therapy. If their homes have been contaminated with the eradicated microbe, could patients suffer a relapse by way of reinoculation? This was the question asked by a group of physician scientists, whose findings were recently pub... Read More

BacterioFiles 253 - Probiotics Promote Protective Pathway

This episode: In mice and fruit flies, Lactobacillus species induce gut cells to protect themselves from reactive oxygen compounds!


(8.2 MB, 8.9 minutes)


Show notes: 
Read More

Zika virus and microcephaly

Three reports have been published that together make a compelling case that Zika virus is causing microcephaly in Brazil. Read More

TWiV 380: Viruses visible in le microscope photonique

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a bri... Read More

TWiV 371: Sympathy for the devil

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

TWiV 367: Two sides to a Coyne

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Read More

TWiV 372: Latent viral tendencies

Hosts: Vincent RacanielloAlan DoveRich Condit Read More

Permissive vaccines and viral virulence

A permissive vaccine prevents disease in the immunized host, but does not block virus infection. Would a permissive vaccine lead to the emergence of more virulent viruses?

This hypothesis is based on the notion that viruses which kill their hosts too quickly are not efficiently transmitted, a... Read More

BacterioFiles 258 - Transformed Toxin Translocates Treatments

This episode: Bacterial toxins could be modified to deliver life-saving proteins into neurons!


(11.1 MB, 12.1 minutes)


Show notes: 
Journal Paper:

Chen C, Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT. 2015.... Read More

TWiP 110: Malaria at the Bronx Zoo

The TWiP trio visit the Bronx Zoo where Paul solves the case of the Four Year Old with Pulmonary Edema, and talks about his career as the Chief Veterinarian and Director of the Zoological Health program for the Wildlife Conservation Society.


Hosts:  Read More

MMP #10: Examining the gut microbiota of American Indians of Cheyenne and Arapaho ancestry.

Host: Jeff Fox with special guests, Cecil M. Lewis, Jr. and Krithivasan Sankaranarayanan.


Lewis and Krithivasan Sankaranarayanan—“Krithi”-- both fro... Read More

Prion contamination in the emergency room

Here is a follow-up to last week’s article that described a case of variant Creutzfeldt-Jacob disease in a Texas resident caused by ingestion of BSE-contaminated beef 14 years ago.

A 59 year old male patient was admitted to the trauma unit in Lancaster, PA with a self-inflicted gunshot wound ... Read More

Freshman Symbiosis Course and Jack Gilbert!

As my Fall semester approaches, I am reflecting on last Fall. I taught a freshman seminar course revolving around symbioses and parasitism, and was fortunate to have many well known scientists be willing to "virtually visit" my class! Here is my report from last year on the great Jack Gilbert.... Read More

Predicting UTI antibiotic resistance

By now, the news of a colistin-resistant E. coli isolate from a patient in the United States is widespread, with many major news sources covering the story. Most outlets highlighted the ease of future transfer of the plamid-borne mcr-1 gene between bacteria, the role of agricultural antibiotic u... Read More

TWiV 386: The dolphins did it

Hosts: Vincent RacanielloRich Condit, and  Read More

Honoring the Memory of Another

The late Edward Leadbetter had a huge impact on my life as an academic, and a microbiologist. In this post, I try to give some appreciation to what he meant to me. Read More

TWiV 385: Failure

Hosts: Vincent Racaniello and Dickson Despommier


Guest: Stuart Firestein Read More

BacterioFiles 251 - Mycophagous Myrmicinae Mutualist Microbes

This episode: Gut bacteria seem to help ants with very restrictive diets flourish more!


(10.6 MB, 11.5 minutes)


Show notes: 
Journal Paper


Read More

Portraits of Microbiologists Using Luminous Bacteria as "Paint."

My wife Jennifer Quinn​ hits it out the park: a portrait of Kenneth Nealson​ and the late Woody Hastings "painted" with luminous bacteria, giving them props for the early days of quorum sensing---where the basic principles were first uncovered in bioluminescent microbes. This principle of "aut... Read More
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