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Permissive vaccines and viral virulence

A permissive vaccine prevents disease in the immunized host, but does not block virus infection. Would a permissive vaccine lead to the emergence of more virulent viruses?

This hypothesis is based on the notion that viruses which kill their hosts too quickly are not efficiently transmitted, a... Read More

BacterioFiles 259 - Fluke Froth Fosters Fester Fixing

This episode: I converse with Dr. Michael Smout about a liver fluke parasite could help heal chronic wounds more quickly!


(13.4 MB, 14.6 minutes)


Show notes: 
Read More

TWiP 67 letters


CN writes:


Greetings Profs,


After having listened to your discussions on Plasmodium (TWiP 64), I explored papers on treatment options that are actually available. After having read some papers, I realized that one of the main roadblocks are the hypnozoite... Read More

TWiM #49 transcript

Here is a transcript of TWiM episode #49, "Grape-like clusters". Thanks to Frank Shinneman for transcription.


The transcript is also available as a pdf file - click... Read More

TWiV 289: Vinny and the capsids

Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.


Hosts:  Read More

TWiV 330: A swinging gate

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

A retrovirus makes chicken eggshells blue

When you purchase chicken eggs at the market, they usually have white or brown shells. But some breeds of chicken produce blue or green eggs. The blue color is caused by insertion of a retrovirus into the chicken genome, which activates a gene involved in the production of blue eggs. Read More

TWiM #6 transcript

Here is a transcript of TWiM episode #6, "Antibacterial therapy with bacteriophage: Fact or fiction?". Thanks to Steve Stokowski for transcription.


The transcript is also available as a pdf file - click here to download Read More

Spread of koala retrovirus in Australia

The Koala retrovirus (KoRV) continues to spread within Australia, according to results of a new analysis of a larger sample size from a wider geographical range than was previously studied. Read More

New Twitter-like Service for Scientists Launched

A new Twitter-FaceBook-FriendFeed-like site called Sciencefeed allows users to post short messages around on scientific-related content, including news headlines, new findings, metings, events and ideas. Just lke Twit... Read More

Museum pelts help date the koala retrovirus

The genomes of most higher organisms contain sequences from retroviral genomes called endogenous retroviruses (ERVs). These are DNA copies of retroviral RNAs that are integrated into the germ line DNA of the host, and passed from parent to offspring. In most species the infections that lead to g... Read More

Download Poster (2003)


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Peptidoglycan remodeling and conversion of an inner membrane into an outer membrane during sporulation

I just finished listening to the TWiM 35 on LPS in Vibrio (among other topics). Dr. Elio Schaechter mentioned a field in Microbiology that I think is of great interest to the scientific community and should definitely be covered in a podcast. The topic is: Outer Membrane Biogenesis in Gram-negat... Read More

Evolution of a DNA Sequence Over Time

One of the basic requirements of evolution is variation in a population upon which selection can act. One of the sources of variation is mutation in DNA. These changes may or may not be reflected in the ensuing amino acid sequence of a protein. This exercise explores the additive effects of m... Read More

TWiV 383: A zillion Zika papers and a Brazilian


Hosts: Vincent RacanielloDickson DespommierAlan Dove and  Read More

Protection against 2009 influenza H1N1 by immunization with 1918-like and classical swine viruses

Influenza A viruses typically cause severe respiratory disease mainly in the very young or the elderly. The 2009 swine-origin H1N1 virus is unusual because it preferentially infects individuals under 35 years of age. We’ve previously noted that being older is a good defense against 2009 H1N1 inf... Read More

TWiV special: MERS-coronavirus in dromedary camels

Unable to embed Rapid1Pixelout audio player. Please double check that:  1)You have the latest version of Adobe Flash Player.  2)This web page does not have any fatal Javascript errors.  3)The audio-player.js file of Rapid1Pixelout has been included.

Host: Vincent Racaniello


Guests: Read More

TWiV 381: Add viruses and Zimmer

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

Sanctuary chimps show high rates of drug-resistant staph

Chimpanzees from African sanctuaries carry drug-resistant, human-associated strains of the bacteria Staphlyococcus aureus, a pathogen that the infected chimpanzees could spread to endangered wild ape populations if they were reintroduced to their natural habitat, a new study shows.

The study ... Read More

TWiM 80 Letters

Bob writes:


Dear TWIM hosts,


I enjoyed episode 76, "Genetic biopixels and a pathogenic sweet tooth". I really enjoyed hearing about the course that Dr. Schaechter teaches and in particular the work his students did in developing the biosensor. I would like to ... Read More

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