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A system‐level model for the microbial regulatory genome

Microbes can tailor transcriptional responses to diverse environmental challenges despite having streamlined genomes and a limited number of regulators. We present data‐driven models that capture the dynamic interplay of the environment and genome‐encoded regulatory programs of two types of prok... Read More

Rhizopus microsporus

Rhizopus microsporus
It causes human mucormycosis and bovine mycotic abortion.
It is distinguished from R.arrhizus by its shorter stalk, and smaller sporangia and spores.
Variant forms
Var.oligosporus : has elongated columellae ; spores less obviously striated.
Var.rhizopodiformis : has ... Read More

El Podcast del Microbio" Nº 152 and 153. El experimento de Tuskegee (The Tuskegee Syphilis Experiment)



























El Podcast del Microbio" Nº 152 and 153 deals with the history of the infamous Tuskegee Syphilis Experiment and its follow-... Read More

El Podcast del Microbio Nº 361. Resistencia a los antibióticos, un problema de narices. (Antibiotic resistance, just under your nose)



























El podcast del microbio Nº 361 summarize the article writen by Marks LR, Reddinger RM and Hakansson AP and published in mBio about the high levels of genetic recombination in Streptococcus pneumoniae ... Read More

A virology course for all

The spring semester has begun at Columbia University, which means that it is time to teach my virology course. The fourth annual installment of my virology course, Biology W3310, has begun. This course, which I taught for the first time in 2009, is intended for advanced undergraduates and conven... Read More

TWiV 105 Letters

Timothy writes


Dear Vince and Alan,


Being a seasoned virologist and a science writer, I was hoping you could discuss the interface between basic science, public health, the media and the general public...


While I was listening to you d... Read More

India has been free of polio for three years

Three years ago today, on 13 January 2011, the last case of poliomyelitis was reported in India. This achievement represents a remarkable turnaround for a country where control of the disease had for years been extremely difficult. As recently as 2009 there were 741 confirmed cases of polio caus... Read More

TWiV 281: The Salk legacy with Peter L. Salk



Host: Vincent Racaniello


Guest: Peter L. Salk


Vincent meets up with Peter L. Salk to talk about development of the fir... Read More

El podcast del microbio Nº 255: Hongos contra el picudo rojo (Fungi against the red palm weevil )



























El podcast del Microbio Nº255 explains the use of the fungus Beauveria bassiana as bioinsecticide for the control of the red pa... Read More

Important Considerations for Determining qPCR Efficiency

One of the very first things you need to do when getting set up for quantitative PCR (qPCR) is to determine the efficiency of the assay because knowing the assay efficiency is critical to accurate data interpretation. And you have to do this every time you design and purchase a new primer pair.
... Read More

TWiM #86: Blurring the line between organelle and endosymbiont

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

TWiV 265: This year in virology

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Hosts: Vincent Racaniello, Alan Dove... Read More

Drivers of bacterial à-diversity depend on spatial scale

PDF of recent "Open Access" PNAS paper on bacterial biogeography. The paper (of which I am an author) made use of rRNA PCR to survey bacteria in salt marshes. The bacteria were surveyed broadly (using broadly targeted PCR primers) and narrowly (using primers that focused on specific taxonomic... Read More

Precious Metals

Moselio Schaechter of the Small Things Considered blog reviews the results of a recent paper "Microbial metalloproteomes are largely uncharacterized" from the Department of Biochemistry and Molecular Biology at the University of Georgia, Athens, and ponders its implications.

Snippet:

"Now... Read More

TWiV 57

dooleyperiod_7-8_ab Read More

1 in 25 patients gets infection in hospital

When antibiotics first started being used in the 1940's they were considered a "miracle drug". It seemed that bacterial infections would no longer be a problem for the world. However, recently, one gene is making it seem as though the end of antibiotics is at hand. This gene is New Delhi metallo... Read More

Henrietta Lacks (HeLa) genome sequence published then withdrawn

Earlier this month the European Molecular Biology Laboratory (EMBL) published the DNA sequence of the genome of HeLa cells, the cell line that is widely used for research in virology, cell biology, and many other areas. This cell line was produced from a tumor taken from Henrietta Lacks in 1951.... Read More

Classifications: What Difference Does it Make?

Does a bacterium’s cell wall, shape, way of moving, and environment really matter?

Yes! The more we know about bacteria, the more we are able to figure out how to make microbes work for us or stop dangerous ones from causing serious harm. And, for those of us who like to ponder more philosop... Read More

Illustrating Some Simple Microbiological Concepts: Transformation, Antibiotic Resistance, and GFP.

In this blog post, I describe a simple "colony transformation" experiment I have done with my freshman students, illustrating transformation, antibiotic resistance, and GFP. The visual aspects help drive home the points effectivel. Read More

How Small Can You Get

parvovirus_B19 Read More

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