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TWiM #46 transcript

Here is a transcript of TWiM episode #46, "Spore!". Thanks to Frank Shinneman for transcription.


The transcript is also available as a pdf file - click here to download.


Read More

The most important paper ever in microbiology

Jonathan Eisen (@phylogenomics on Twitter) has a new post on his The Tree of Life blog that looks at why the paper "Phylogenetic structure of the prokaryotic domain: The primary kingdoms" by Carl Woese and George Fox may be the most important paper (see http://www.pnas.org/content/74/11/5088.ful... Read More

El podcast del Microbio Nº 286. Mutaciones tempranas en el VIH (Early mutations in HIV)



























El podcast del Microbio Nº 286 summarize the article by Henn et al published in PLoS: Pathogens about the impact of early minor ... Read More

El podcast del Microbio 110 y 111: La estirpe de Caín

The Nº 110 and 111 of "El podcast del microbio" describes the fratricide behaviour of Streptococcus pneumoniae and the role of Lyt C autolysisn. En "El podcast del microbio" Nº 110 y 111 se habla del comportamiento fratricida de Streptococcus pneumoniae y el papel de la autolisina Lyt C.

{mp... Read More

TWiP 3 letters

Björn writes: (first letter to TWiP)


Hi Dick and Vincent,



My name is Björn. I am a biochemist and PhD student working on trypanosomes here in Germany. I am a long time listener of your twiv podcast and just listened to the first  Read More

Do Hand Sanitizer and Liquid Hand Soap Remove Viruses?

While reading my back issues of Applied and Environmental Microbiology (AEM), I came across an interesting paper that detailed an in-depth study on the effectiveness of hand cleaners to remove Norwalk virus (NV) from intentionally contaminated hands.

Yes that’s right – intentionally contamina... Read More

A single amino acid change switches avian influenza H5N1 and H7N9 viruses to human receptors

Two back-to-back papers were published last week that provide a detailed analysis of what it would take for avian influenza H5N1 and H7N9 viruses to switch to human receptors. A single amino acid change in the viral hemagglutinin protein is sufficient to quantitatively change binding of the viru... Read More

TWiV 48

Rodney writes:


Hello, I have been an avid listener of TWiV over the last 9 months or so and have very much enjoyed the podcast. It is always great to hear a broad, informed discussion on virology, and your recent podcast on viral classification was of particular interest to m... Read More

Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?

There have been over 60 human infections with avian influenza virus H7N9 in China, and cases have been detected outside of Shanghai, including Beijing, Zhejiang, Henan, and Anhui Provinces. Information on the first three cases has now been published, allowing a more detailed consideration of the... Read More

Audio interview with Dylan Pillai of the University of Toronto

Jeff Fox of Microbe magazine interviews Dylan Pillai of the University of Toronto on how genomic analysis is used by epidemiologists and clinical microbiologists to reconstruct bacterial disease outbreaks or analyze difficult individual cases Read More

Lab Tests Online - a resource site for patients, caregivers and medical professionals

Lab Tests Online has been designed to help you, as a patient or family caregiver, to better understand the many clinical lab tests that are part of routine care as well as diagnosis and treatment of a broad range of conditions and diseases. If you are a medical professional, this site can serve ... Read More

Scientists for Science

Scientists for Science are confident that biomedical research on potentially dangerous pathogens can be performed safely and is essential for a comprehensive understanding of microbial disease pathogenesis, prevention and treatment. The results of such research are often unanticipated and accrue... Read More

Robert A. Weisberg, 1937-2011

Robert A. Weisberg was a Scientist Emeritus at NCI until the time of his death on 1 September 2011. Previously he was Chief of Microbial Genetics at NICHHD, a position he retired from in 2008. He was a pioneer in the study of the bacteriophage lambda. His research lead to seminal contributions a... Read More

TWiP 76: Herpesvirus worms its way out

Vincent and Dickson discuss how infection of mice with helminths induces cytokines that reactivate a latent gamma-herpesvirus.


Hosts: Vincent Racaniello and  Read More

XMRV, Chronic Fatigue and prostate cancer

The XMRV retrovirus has been implicated in chronic fatigue syndrome and prostate cancer. A homology search comparing retroviral with human proteins revealed short contiguous amino acid strings (typically 5-8 aa) matching human proteins whose dysfunction might be expected to cause fatigue, includ... Read More

Report to the President on U.S. Preparations for 2009-H1N1 Influenza

Click "source" to view the full "Report to the President on U.S. Preparations for 2009-H1N1 Influenza" from the President’s Council of Advisors on Science and Technology.

Here is the Council's "planning scenario":

Indeed, the 2009-H1N1 influenza is already responsible for significant morbi... Read More

Collection of Microbial Discovery Activities for K-12

The American Society for Microbiology has posted a collection of Microbial Discovery Activities designed for K-12 teachers to facilitate the incorporation of microbiology within science courses. Activities come from the community at large. All submissions are reviewed by the ASM Committee on K-1... Read More

Pandemics in Retrospective

Now that we have experienced several months of the H1N1 pandemic, what have we learned about how it was handled? Watch Dr. Nicole Lurie (U.S. Department of Health and Human Services) and Dr. Kathryn Edwards (Vanderbilt University), discuss the public health responses to H1N1. Participants compar... Read More

TWiP 50 Letters

Alaric writes:


Hello Vince and Dick,


I just found your podcast and I love it! You have some wonderfully witty banter.


I am only on my 4th episode (that's what you call a podcast segment right?), and have a question pertaining to my original reason for ... Read More

Biotech Revolution (BBC Four)

Theoretical physicist and futurist Michio Kaku looks at the revolution in genetics and biotechnology, which promises unprecedented health and longevity but also raises fears of a future where we can genetically engineer people. The documwentary asks will we, as transhumanists expect, evolve into... Read More

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