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The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory – a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

El Podcast del microbio Nº 193 Con un poco de azúcar (A spoonful of sugar)

El podcast del Microbio Nº193 describes the mBio 2010 paper by Huang et al. about the use of β-Glucan Particles to stimulat... Read More

Evolution of a DNA Sequence Over Time

One of the basic requirements of evolution is variation in a population upon which selection can act. One of the sources of variation is mutation in DNA. These changes may or may not be reflected in the ensuing amino acid sequence of a protein. This exercise explores the additive effects of m... Read More

Common Sense Advice for People Concerned About H1N1 (Swine Flu)

The New York Times has published a nice FAQ ,if you will, about H1N1 and what the general public should keep in mind in terms of worry, protection and symptoms. The article also talks about what public health response is feasible and should be expected. Read More

Use of a Class 1 Safety Cabinet (video)

This video shows you how a Class 1 microbiological safety cabinet works. Read More

TWiV 245: Writing Principles of Virology

Unable to embed Rapid1Pixelout audio player. Please double check that:  1)You have the latest version of Adobe Flash Player.  2)This web page does not have any fatal Javascript errors.  3)The audio-player.js file of Rapid1Pixelout has been included.

Host: Vincent Racaniello

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El podcast del microbio Nº203: Antiguos eucariotas no marinos (earliest non-marine eukaryotes)

El podcast del Microbio Nº203 is dedicated to Earth’s earliest non-marine eukaryotes, a discovery published in Nature journ... Read More

A Guide to Swine Flu (SciAm)

As swine influenza reaches the U.S., a guide to what you need to know and what happens next. Plus, a look at pandemics past... Read More

BacterioFiles 216 - Probiotic Promotes Peanut Permissiveness

This episode: Kate Franz and Matt Woodruff from Audiommunity join me to talk about a clinical trial of peanut immunotherapy with probiotics to treat peanut allergies!

(29 MB, 31.75 minutes)

Show notes: 
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Spread of koala retrovirus in Australia

The Koala retrovirus (KoRV) continues to spread within Australia, according to results of a new analysis of a larger sample size from a wider geographical range than was previously studied. Read More

Compiling a list of reporters who cover #microbiology stories well; suggestions wanted

I am attempting to compile a list of reporters who do a good job covering microbiology related topics. I have compiled a partial list and am soliciting additional suggestions. Read More

Ice Nucleation Bacteria, Twitter, and Me!

In this post from my microbiology/education blog, I discuss a post on Boing Boing recently that used a video I had made of ice nucleation bacteria. Ice nucleation bacteria are very interesting of course, and I link to the Boing Boing post. In addition, I provide an additional video of students... Read More

TWiV 353: STING and the antiviral police

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

TWiV 301: Marine viruses and insect defense

At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.

Host:  Read More

Stopping malaria in its tracks

A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans. Read More

Development of an HIV-1 Specific Microbicide Using Caulobacter crescentus

A recent paper published in PLoS One looks at the strategy of manipulating surface proteins on the aquatic bacterium, Caulobacter crescentus, to prevent HIV infection.


The development of alternative strategies to prevent HIV infection is a global public health priority. Initial e... Read More

1977 H1N1 influenza virus is not relevant to the gain of function debate

The individuals who believe that certain types of gain-of-function experiments should not be done because they are too dangerous (including Lipsitch, Osterholm, Wain-Hobson,) cite the 1977 influenza virus H1N1 strain as an example of a laboratory accident that has led to a global epidemic. A new... Read More

TWiV 77

Wladimir writes:

In regard to your question as to cases of known alteration of host behavior by virus that increases the rate of contact among hosts (Twiv 70), the most dramatic example is given by rabies. This extraordinary virus can convert a neurologically and behaviorally... Read More

Toxoplasmosis: A T.Gondii Host-pathogen interactome

This parasite interacts with many host proteins and modifies the expression of many more genes creating an interactome with almost 3000 links. In addition it exchanges substrates and metabolites with the host, modifying many biochemical parameters. T.Gondii disrupts multiple signalling network... Read More

Interview of Dr. Tim Sandle

Q) Dr. Tim Sandle, the well known researcher, professor, author and science communicator. It is much interesting for me to take an interview of an eminent person who is well known for the communicating science. Starting from your early childhood life, how you used to take science as that time?
... Read More
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