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Building Community through Public Toilets

The Global Water Challenge (GWC) is a coalition of leading organizations in the water and sanitation sector. In this video GWC finalist David Kuria of Ecotact Limited, a Kenyan company dedicated to bringing public toilets to an area where there were only two for 60,000 people, discusses the need... Read More

Using Bacteria to Turn Sand Dunes into Architecture

Architecture student Magnus Larsson details his bold plan to transform the harsh Sahara desert using bacteria and a surprising construction material: the sand itself. Read More

BacterioFiles 225 - Implanting Internal Invader Immunity

This episode: Don't have immunity? Create your own! Scientists engineer cells to destroy their HIV infections using the bacterial immune system!


(14.5 MB, 15.8 minutes)


Show notes: 
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BacterioFiles 190 - Bacteriophages Bust Biofilm Beacons

This episode: Engineered phages can both kill bacteria and disrupt their communications!


(14.8 MB, 16.2 minutes)


Show notes: 
Journal Paper


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Paleovirology—Modern Consequences of Ancient Viruses

Here's an interesting essay published in PLoS Biology by Michael Emerman and Harmit S. Malik on paleovirology, a topic recently discussed by Welkin Johnson, on the Small Things Considered blog.


<... Read More

Microbial Warfare in the Underworld: Searching for New Antibiotics

This month we talked with Dr. Christine Salomon, Assistant Professor at the Center for Drug Design in the University of Minnesota. Dr. Salomon’s work intersects chemistry and microbial ecology in the hunt for interesting new natural products with far reaching potential applications. While much... Read More

Thirty years in my laboratory at Columbia University

Thirty years ago this month I arrived in the Department of Microbiology at Columbia University’s College of Physicians and Surgeons (P&S) to start my own laboratory. Thirty is not only a multiple of ten (which we tend to celebrate), but also a long time to be at one place. It’s clearly time to r... Read More

Toxoplasmosis: A T.Gondii Host-pathogen interactome

This parasite interacts with many host proteins and modifies the expression of many more genes creating an interactome with almost 3000 links. In addition it exchanges substrates and metabolites with the host, modifying many biochemical parameters. T.Gondii disrupts multiple signalling network... Read More

Whooping cough predicted to double in 20 years, new vaccination strategies will be needed

A new paper in PLoS recommends two vaccination strategies to better prevent whooping cough.

"In the absence of adolescent or adult vaccination, pertussis incidence among adults is predicted to more than double in 20 years. Implementing an adult program in addition to childhood and adolescent... Read More

TWiM 110 Letters

Trudy writes:


I'm sorry, I may have missed something, but the mechanism behind an effective vaccine is still unclear to me, since infection with F. tularensis does not confer protection. How would a vaccine work?


Katy Bosio replies:


In... Read More

TWiP 89: Day TWiPers

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.


Hosts: Vincent Racaniello,&... Read More

Rhizopus microsporus

Rhizopus microsporus
It causes human mucormycosis and bovine mycotic abortion.
It is distinguished from R.arrhizus by its shorter stalk, and smaller sporangia and spores.
Variant forms
Var.oligosporus : has elongated columellae ; spores less obviously striated.
Var.rhizopodiformis : has ... Read More

Koch’s postulates in the 21st century

For thousands of years, epidemics of contagious diseases were believed to be caused by the wrath of the gods, configuration of stars, or miasma. The association of specific microorganisms with disease came about as a consequence of the work of the German physician Robert Koch. He formulated a se... Read More

Ice Nucleation Bacteria, Twitter, and Me!

In this post from my microbiology/education blog, I discuss a post on Boing Boing recently that used a video I had made of ice nucleation bacteria. Ice nucleation bacteria are very interesting of course, and I link to the Boing Boing post. In addition, I provide an additional video of students... Read More

Sanctuary chimps show high rates of drug-resistant staph

Chimpanzees from African sanctuaries carry drug-resistant, human-associated strains of the bacteria Staphlyococcus aureus, a pathogen that the infected chimpanzees could spread to endangered wild ape populations if they were reintroduced to their natural habitat, a new study shows.

The study ... Read More

The risks and benefits of influenza H5N1 research

Both Nature and the New York Times have weighed in on the resumption of influenza H5N1 research. In an editorial from 23 January 2013, Nature opines that “Experiments that make deadly pathogens more dangerous demand the utmost scrutiny”. They call for a quantitative risk-benefit analysis of H5N1... Read More

TWiV 228: Cal Bears go viral

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Hosts: Vincent Racaniello, Britt Glaunsinger, and Read More

TWiP 71 letters


Heather writes:


Hi Dr.s R&D,


I thought you might be interested in this news article about aquaculture in Hong Kong. Perhaps it's time for another fish parasite episode? I love the podcast, keep up the great work.


Heather


Bill writes: Read More

BacterioFiles Micro Edition 27 - Ingenious Influenza Immunizations

This episode: Flu vaccine made by bacteria!


Unable to embed Rapid1Pixelout audio player. Please double check that:  1)You have the latest version of Adobe Flash Player.  2)This web page does not have any fatal Javascript errors.  3)The audio-player.js file of Rapid1Pixelout has been included.

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Stopping malaria in its tracks

A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans. Read More
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