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Architecture of a bullet-shaped virus

Since electron micrographs first revealed the bullet-shaped morphology of vesicular stomatitis virus (a virus related to rabies virus), understanding the architecture has been elusive. It was known that the RNA genome is wrapped in a helical structure by the viral nucleocapsid (N) protein, but h... Read More

An antiviral for enveloped viruses

Broad spectrum antibiotics are available that act against a wide range of bacteria, including both gram-positive and gram-negative species. In contrast, our antiviral arsenal is exceedingly specific. Nearly all the known antivirals block infection with one or two different viruses. The discovery... Read More

TWiV 70: Hacking aphid behavior

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On episode #70 of the podcast This Week in Virology, Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host ... Read More

How To Prevent Other People’s Mistakes from Affecting Your Work

Chances are, in the course of your scientific career, you will encounter a common problem in research: losing time due to someone else’s mistake. Whether the problem is an incorrect strain or plasmid given to you by another lab, incorrectly made buffers or media from within your own lab, or, in ... Read More

A Prophage Masquerade

Small Things Considered blogger Merry Youle has authored a post on the sequencing of Roseovarius nubinhibens. a bacterium that recently joined the group of about a thousand bacteria whose genomes have been sequenced. Researcher José González and colleagues in Mary Ann Moran's lab at the Universi... Read More

MTS44 Michael Worobey - In Search of the Origin of HIV and H1N1's Hidden History

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Five questions about lysogeny

Merry Youle from www.smallthingsconidered.us explores 5 questions about lysogeny, the life cycle that takes place when a bacteriophage infects certain types of bacteria. Read More

Monitoring H1N1 with Twitter--interview with Philip Polgreen of the University of Iowa

Micro-blogging via Twitter is being evaluated as a means for tracking infectious diseases. The 2009 outbreak of H1N1 provided them an opportunity for testing Twitter as an approach for tracking disease outbreaks. From the end of April, researchers at the University of Iowa began collecting Twitt... Read More

XMRV not found in 170 additional UK chronic fatigue syndrome patients

A new retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), first identified in tumor tissue of individuals with prostate cancer, was subsequently found in 68 of 101 US patients with chronic fatigue syndrome (CFS). XMRV was not detected in blood samples of 186 confirmed CFS patient... Read More

New Twitter-like Service for Scientists Launched

A new Twitter-FaceBook-FriendFeed-like site called Sciencefeed allows users to post short messages around on scientific-related content, including news headlines, new findings, metings, events and ideas. Just lke Twit... Read More

Of Archaeal Periplasm and Iconoclasm

Moselio Schaechter of the Small Things Considered blog reviews the surprising findings in the paper "Energized outer membrane and spatial separation of metabolic processes in the hyperthermophilic Archaeon Ignicoccus hospitalis" published in the recent Proceedings of the National Academy of Scie... Read More

Protection against 2009 influenza H1N1 by immunization with 1918-like and classical swine viruses

Influenza A viruses typically cause severe respiratory disease mainly in the very young or the elderly. The 2009 swine-origin H1N1 virus is unusual because it preferentially infects individuals under 35 years of age. We’ve previously noted that being older is a good defense against 2009 H1N1 inf... Read More

Nature launches iPhone app

Nature magazine has just launched an iPhone application. It's essentially an eBook reader for the iPhone and iPod Touch that gives all access to Nature and Nature News content as it is published for free until April 30th when presumably they will start charging. It's available in the app store n... Read More

Check out over 300 Microbiology-related Videos Online

A. J. Cann of the infamous MicrobiologyBytes.com blog and podcast has a collection of over 300 microbiology related videos on his site. While the videos are all copyrighted, you can view hundreds of .mov examples on the web.

Here's an example (with permission) of Hartmannella, "a harmless, fr... Read More

Naegleria fowleri Infection Fact Sheet

Naegleria is an amoeba commonly found in warm freshwater and soil. Only one species of Naegleria infects people, Naegleria fowleri. Naegleria infects people by entering the body through the nose, often occurring when people use warm freshwater for activities like swimming or diving. The amoeba c... Read More

Naegleria’s Split Morphology Disorder

A guest blog post by "Psi Wavefunction" on Small Things Considered explores the morphology of Heterolobosea, specifically Naegleria, a species of pathogenic free-living amoebae that have a taste for human brains. Read More

Virology course videocasts

This year I started a new virology course at Columbia University. The course emphasizes the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycl... Read More

TWiV 69: They're all safecrackers

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On episode #69 of the podcast This Week in Virology, Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 191... Read More

Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution

Thomas Cavalier-Smith, Department of Zoology, University of Oxford, has published a paper in which he identifies some of the key elements to understanding eukaryogenesis.

"Here I paint an integrated picture of how the nucleus, sex, and the eukaryotic cell cycle originated and congealed into ... Read More

Now playing: Viral plaque formation

One of the most important procedures in virology is measuring the virus titer – the concentration of viruses in a sample. A widely used approach for determining the quantity of infectious virus is the plaque assay. In this technique, the spread of progeny viruses released by individually infecte... Read More
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