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Bacteriophage T4 (video)

This is an accurate visualization of the Bacteriophage T4 based on Cryo-EM datasets of the virus. The scope of the animation is to show the infection process of the T4 into an E. coli cell. All scientific data sets and motion based off of research from Michael Rossmann Laboratory (Purdue Univers... Read More

Polio-like paralysis in California

Recently a number of children in California have developed a poliomyelitis-like paralysis. The cause of this paralysis is not yet known, and information about the outbreak is scarce. However, acute-flaccid paralysis is not uncommon (California would be expected to report about 75 cases a year, b... Read More

New Report Released by the American Academy of Microbiology: "FAQ: West Nile Virus"

The American Academy of Microbiology has released its newest report about the West Nile virus. Questions answered include: Can West Nile virus outbreaks be prevented? Why do some people get West Nile fever? How did the West Nile virus spread across the country so quickly?

The free report can ... Read More

TWiV 270: Homeland virology



Hosts: Vincent Racaniello and Rich Condit Read More

Retroviruses R us

About eight percent of human DNA is viral – remnants of ancestral infections with retroviruses. These endogenous retroviral sequences do not produce infectious viruses, and most are considered to be junk DNA. But some of them provide important functions. The protein called syncytin, which is ess... Read More

De-discovering pathogens: Viral contamination strikes again

Do you remember the retrovirus XMRV, initially implicated as the cause of chronic fatigue syndrome, and later shown to be a murine virus that contaminated human cells grown in mice? Another virus thought to be associated with human disease has recently been shown to be a contaminant, derived fro... Read More

Topographic diversity of fungal and bacterial communities in human skin

An interesting recent paper characterizing the fungal microbiome ("mycobiome") of human skin. It would be lovely if the TWIM crew could discuss this in an upcoming episode!

"Traditional culture-based methods have incompletely defined the microbial landscape of common recalcitrant human fungal... Read More

Rhizopus microsporus

Rhizopus microsporus
It causes human mucormycosis and bovine mycotic abortion.
It is distinguished from R.arrhizus by its shorter stalk, and smaller sporangia and spores.
Variant forms
Var.oligosporus : has elongated columellae ; spores less obviously striated.
Var.rhizopodiformis : has ... Read More

Student Creativity and Student Study Guides

In this blog entry, I discuss the perennial problem for educators: helping students find study strategies that help them reach their educational goals. I have found that student-generated study material is most helpful...and is sometimes quite artistic! Read More

Rhizopus microsporus

Rhizopus microsporus
It causes human mucormycosis and bovine mycotic abortion.
It is distinguished from R.arrhizus by its shorter stalk, and smaller sporangia and spores.
Variant forms
Var.oligosporus : has elongated columellae ; spores less obviously striated.
Var.rhizopodiformis : has ... Read More

The science-themed art of Deb Sklut

During my visit to Berkeley, CA to record TWiV #228, I met Deb Sklut, an artist who is inspired by the power of science. I recorded a brief conversation with Deb which you can view below. Her work can be found at SqueakySqueegeeArt.etsy.com. Read More

Human Microbiome Report & Infographic

The human microbiome, the collection of trillions of microbes living in and on the human body, is not random, and scientists believe that it plays a role in many basic life processes. As science continues to explore and better understand the role of the human microbiome. A new report from the Am... Read More

Viral gifts

If you are looking for the perfect present for that infectious person in your life, there are many microbe-themed possibilities. Here are some suggestions, from t-shirts, to watercolors, glass sculptures, and paper to wrap it in. Read More

Part of MERS-CoV nucleotide sequence found in a bat

What is wrong with this paragraph from today’s New York Times that describes the origin of the Middle East Respiratory Syndrome (MERS) coronavirus:

Health officials confirmed Wednesday that bats in Saudi Arabia were the source of the mysterious virus that has sickened 96 people in the Middle ... Read More

John Holland, 83

Virologist John Holland passed away on 11 October 2013. I asked former members of his laboratory for their thoughts on his career and what he meant to them. Read More

MERS Virus Widespread in Saudi Arabian Camels (News Release)

The coronavirus responsible for Middle East Respiratory Syndrome (MERS) is prevalent in camels throughout Saudi Arabia and has been around for at least 20 years, according to a study to be published in mBio®, the online open-access journal of the American Society for Microbiology.

“Our study ... Read More

Stability of MERS Under Different Environmental Conditions (research)

The stability of Middle East respiratory syndrome coronavirus (MERS-CoV) was determined at 20°C – 40% relative humidity (RH); 30°C – 30% RH and 30°C – 80% RH. MERS-CoV was more stable at low temperature/low humidity conditions and could still be recovered after 48 hours. During aerosolisation of... Read More

Inadvertent transfer of a mammalian retrovirus into birds

Reticuloendotheliosis viruses (REVs) are retroviruses that cause a rare disease of gamebirds and waterfowl that includes anemia, immunosuppression, neoplasia, runting, and abnormal feathering. Since the first isolation of REV from a turkey in 1957, REVs were believed to be strictly avian viruses... Read More

How to use Fluorescent dyes or Click Chemistry in research

Protocols and free how to advice from Lumiprobe on how to use Fluorescent dyes, Click Chemistry reagents, Life Science
-Click-chemistry labeling of oligonucleotides and DNA.
-NHS ester labeling of amino biomolecules.
-SYBR Green I staining of DNA in gels.
-qPCR with SYBR Gree... Read More

Graduation, Richard Feynman, and Career Choices...

In this blog post, I discuss how students begin to find their "path" to a career that they will love in science. I aIso write about the late, great Richard Feynman. Read More

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