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BacterioFiles 238 - Forcing Fungal Familiarization

This episode: Of genes that are similar in yeast and humans, almost half of the yeast versions are functional when replaced with the human version!

(7.9 MB, 8.5 minutes)

Show notes: 
Read More

Viral variation in single cells

It is well known that virus populations display phenomenal diversity. Virus populations are dynamic distributions of nonidentical but related members called a quasispecies. This diversity is restricted in single cells, but is restored within two infectious cycles. Read More

TWiM 98 Letters


Patrick writes:

Hi Vincent,

I thought you and the rest of the TWiM/TWiP folks would be interested in the following paper: Transferred interbacterial antagonism genes augment eukaryotic innate immune function, published online in Nature this week... Read More

My first "Mu-Tube" video promoting microbial literacy: What does "microbiology" mean to students?

For my Microbiology course at the University of Puget Sound, I decided to ask my new crop of "micronauts" what the word "microbiology" meant to them on the first day of class. Here are their answers. My wife Jennifer Quinn and I put this together using art from former students. Hopefully, thi... Read More

TWiV 326: Giving HIV a flat tyr

Hosts: Vincent RacanielloAlan Dove, and  Read More

TWiP 80 letters

Jessica writes:

Hello Dr Racaniello and Despommier,

I recently saw an article about the paper linked below on Science Daily and thought it might be worth a discussion on TWIP. It is about the possibility of bed bugs being a vector for T. cruzi. I would love to... Read More

TWiV 316: The enemy of my enemy is not my friend

Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contributes to alphavirus pathogenesis.

Hosts: Vincent Racaniello Read More

TWiV 324: Viruses in the miR may appear more numerous

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

HIV cure research: NIH scientists create 2-headed protein to deplete HIV reservoir

Scientists at the National Institutes of Health (NIH) have created a protein that awakens resting immune cells infected with HIV and facilitates their destruction in laboratory studies. The protein potentially could contribute to a cure for HIV infection by helping deplete the reservoir of long-... Read More

Portraits of Microbiologists Using Luminous Bacteria as "Paint."

My wife Jennifer Quinn​ hits it out the park: a portrait of Kenneth Nealson​ and the late Woody Hastings "painted" with luminous bacteria, giving them props for the early days of quorum sensing---where the basic principles were first uncovered in bioluminescent microbes. This principle of "aut... Read More

TWiM 97 Letters

Dennis writes:
hi Doc,

A paper just published in nature:


reports an effective antibiot... Read More

TWiP 91 letters


Heather writes:

Dear Dr.s R, D & G,

I really hate to criticize learned professors, especially my elders. I suspect I may be being overly - sensitive or perhaps it is a cultural difference. However, the "over-talking" is decreasing the qualit... Read More

BacterioFiles 215 - Plasmid Pirates Piezophile Particles

This episode: Deep-sea thermophile bacteriophage is pirated by another scurvy genetic element!

(10.2 MB, 11.2 minutes)

Show notes: 
J... Read More

TWiP 83 letters

Robin writes:

Malaria: shaking chills & fever (followed by sweats, not specifically mentioned in this case), is a characteristic of malaria that is unforgettable once one has had it (I had malaria four times).

Thick blood smears is de rigueur.
So... Read More

TWiV 319: Breaking breakbone

The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.

Hosts: Vincent Racaniello Read More

TWiV 362: Gotta catch 'em all

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Read More

TWiV 314: Einstein goes viral

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.

Host:  Read More

TWiP 82 letters

Allan writes:

Dear Vincent, Dickson and Daniel,

I like your idea of a TWIP coffee mug prize (or maybe a mug discount).

In this second case study you presented, the present symptoms are pretty vague, but his history is interesting. Also since with ... Read More

BacterioFiles 239 - Familial Pheromones Fight faecalis

This episode: Gut bacteria kill their drug-resistant pathogenic cousins of the same species via pheromone signaling!

Just to let you know, I'm trying to finish up my dissertation and graduate in the next few months, so after episode 240, I will be putting the show on hold, at least for... Read More
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