Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) showed clinical improvement after extended treatment with the anti-B-cell monoclonal antibody rituximab. This result suggests that in a subset of patients, ME/CFS might be an autoimmune disease. Read More
This episode: Colonizing ourselves with friendly bacteria could drive out more risky ones, such as those that cause meningitis!
(9.8 MB, 10.6 minutes)
This episode: Programming bacteria to sense and keep genomic records of environmental inputs!
(15.9 MB, 17.4 minutes)
This slideshow outlines the work of WHOI scientists Tracy Mincer and Kristen Whalen in the quest to beat antibiotic resistance through bioprospecting in the ocean. Read More
This episode: Gut bacteria in Mojave desert woodrats help them detoxify and eat toxic creosote bushes!
(10 MB, 10.8 minutes)
Dear Dr. Schaechter,
First off, I want to thank you for the effort you and your colleagues have invested in Small Things Considered and the podcast TWIM. Back when I had a longer commute to work, I listened more religiously than now, wh... Read More
This episode: Engineered phages can both kill bacteria and disrupt their communications!
(14.8 MB, 16.2 minutes)
Parasitic wasps inject their eggs into lepidopteran hosts, where they carry out their developmental stages. Along with the eggs, the wasps also deliver viruses carrying genes encoding proteins which inhibit caterpillar immune defenses. Some of these genes are permanently transferred to the lepid... Read More
This episode: Microbial predators in soil cause microbial prey to build fortifications!
(8.8 MB, 9.5 minutes)
This episode: Fungi can act like sticky nets to help harvest algae for biofuels!
(8.3 MB, 9 minutes)
Although we now understand that viruses are the most abundant organisms on Earth, there are gaps in our knowledge about their distribution in different environments. Results of a new study reveal the diversity and distribution of viruses in Arctic fresh waters. Read More
This episode: Kate Franz and Matt Woodruff from Audiommunity join me to talk about a clinical trial of peanut immunotherapy with probiotics to treat peanut allergies!
(29 MB, 31.75 minutes)
An Ebolavirus vaccine has shown promising results in a clinical trial in Guinea. This vaccine has been in development since 2004 and was made possible by advances in basic virology of the past 40 years. Read More
Back in 2013 I built a Wall of Polio in my laboratory – a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More
This episode: When digesting wood, shipworms outsource their microbial symbionts from gut to gills!
(9.7 MB, 10.6 minutes)
The individuals who believe that certain types of gain-of-function experiments should not be done because they are too dangerous (including Lipsitch, Osterholm, Wain-Hobson,) cite the 1977 influenza virus H1N1 strain as an example of a laboratory accident that has led to a global epidemic. A new... Read More