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TWiP 85: Channeling tryps

Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study.

Hosts: Vincent Racaniello Read More

TWiP 85 letters


Jan writes:

Dear Sirs

This is fun, and although I'm sure someone will gripe about Dicksons enthusiastic response to the crayfish, it made my life easier. I think it's Paragonimus kellicoti. As for eating raw crayfish; how drunk... Read More

BacterioFiles 205 - Colon Community Counterattacks Cholera

This episode: Microbes in the human gut seem to prevent/inhibit cholera!

(10.5 MB, 11.5 minutes)

Show notes: 
Journal Paper

... Read More

My experience with Foldscope, the paper microscope.

My experience with Foldscope, the paper microscope. See the images of insects, parasites, vegetal and animal tissues and cells, yeast, bacteria and (almost) virus (the cytopathic effect), with Foldscope, the paper microscope (text in Spanish). Read More

TWiV 327: Does a gorilla shift in the woods?

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

MWV94 - TWiM #99: Careers in Biodefense

Hosts: Vincent Racaniello

Guests: Maria Julia Marinissen, Read More

TWiM #99: Careers in Biodefense

Hosts: Vincent Racaniello

Guests: Maria Julia Marinissen, Read More

BacterioFiles 204 - Animalcules Assist Agave Amino Accumulation

This episode: Bacteria living in plants seem to be contributing to plants' nutrition, possibly reducing the need for fertilizer!

(17.5 MB, 19.15 minutes)

Show notes: 
Read More

TWiV 326: Giving HIV a flat tyr

Hosts: Vincent RacanielloAlan Dove, and  Read More

Q&A: Seth Mnookin on vaccination and public health

Seth Mnookin, an assistant professor of science writing and associate director of MIT's Graduate Program in Science Writing, is the author of "The Panic Virus: The True Story Behind the Vaccine-Autism Controversy", an acclaimed book that examines how inaccurate scientific reports linking vaccine... Read More

TWiP 84: Bigfoot

Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study.

Hosts: Vincent Racaniello Read More

TWiP 84 letters


Jesse writes:

Doctors TWiP,

I liked the discussion of the interaction of bacteria and Leishmania in sandfly guts; it was very interesting! Here is another suggestion if you need a topic to discuss:

Delivery of a functional anti-trypanoso... Read More

New Drugs May Come from Microbes in Our Guts

Plants and Microorganisms are the major sources of drugs till date. Most of these "natural products" come from a few genera of soil and marine bacteria that have long been known for their prolific chemistry. The classical process of discovering drugs from microorganisms have two drawbacks- it is... Read More

Blocking HIV infection with two soluble receptors

Because viruses must bind to cell surface molecules to initiate replication, the use of soluble receptors to block virus infection has long been an attractive therapeutic option. Soluble receptors have been developed that block infection with rhinoviruses and HIV-1, but these have not been licen... Read More

Ebolavirus will not become a respiratory pathogen

An otherwise balanced review of selected aspects of Ebolavirus transmission falls apart when the authors hypothesize that ‘Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.’

The idea that Ebolavirus might become transmitted by the respiratory route ... Read More

Caring for People Infected with Ebola: Stories from the Frontlines

Call for Stories
Caring for People Infected with Ebola: Stories from the Frontlines
Narrative Inquiry in Bioethics will publish a collection of personal stories from individuals who have been at the frontlines of healthcare for Ebola patients—whether as healthcare workers, family caregivers,... Read More

BacterioFiles 203 - P. putida Promotes Plant Pollutant Purification

This episode: Bacteria living in plants could help plants clean up cancer-causing pollutants!

(6.9 MB, 7.5 minutes)

Show notes: 
News item<... Read More

TWiP 83 letters

Robin writes:

Malaria: shaking chills & fever (followed by sweats, not specifically mentioned in this case), is a characteristic of malaria that is unforgettable once one has had it (I had malaria four times).

Thick blood smears is de rigueur.
So... Read More

TWiP 83: Hidden costs of infection

Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation.

Hosts: Vincent Racaniello Read More

TWiV 325: Wildcats go viral

Hosts: Vincent Racaniello

Guests: Rollie Clem and Lorena Passarelli

{audio... Read More

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