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TWiP 112: A NOD to a tricky helminth

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.


Hosts:  Read More

Dispatches from ASM Microbe: Entire series

Things have been quiet on mBiosphere lately. We've been busy updating from ASM Microbe, covering some of the fascinating research presented there. The first Microbe meeting, which combines the former general meeting and ICAAC, was a whirlwind of poster presentations, lectures, seminars, book sig... Read More

A Tiny Zika Laboratory

So far in this series I’ve written a good deal about our work on Zika virus, but I have said little about the people who are doing the science.

My lab at Columbia University Medical Center is very small, consisting of three people—Amy Rosenfeld, Audrey Warren, and me. Let me tell you about ... Read More

TWiM #130: Interkingdom interactions at ASM Microbe

The TWiMers get together at ASM Microbe 2016 in Boston to speak with David and Vanessa to talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.


Hosts: Read More

Dispatches from ASM Microbe - Monday and wrap-up

After absorbing research on manipulation of the human microbiome, the impact of waterway and agricultural microbiomes, antibiotic resistance spread and the potential of stewardship guard against it, and potential antimicrobial therapies of the future, we have yet to cover an important research t... Read More

BacterioFiles 256 - Virus Versus Virus

This episode: Viruses can cause host cells to inhibit other viruses!


(8 MB, 8.75 minutes)


Show notes: 
Journal Paper:

Chiba S, Suzuki N. 2015. Highly act... Read More

TWiV 394: Cards in a hand

Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.


Hosts:  Read More

Dispatches from ASM Microbe - Sunday

We’ve had a whirlwind of amazing talks, poster sessions, and networking sessions so far at ASM Microbe 2016. In our previous two Dispatches from ASM Microbe, we’ve covered microbiomes, for which research ranges from extremely basic (Which microbes are present? How do we quantify them?) to clinic... Read More

Dispatches from ASM Microbe - Friday

ASM Microbe is the new conference that merges the former General Meeting with the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) to make one microbial sciences-packed meeting with something for everyone. Why institute one new meeting instead of maintaining two separate ... Read More

Dispatches from ASM Microbe - Saturday

Welcome back to Dispatches from ASM Microbe! Today we’ll continue Microbe 2016 highlights of the microbiome, focusing on the non-human microbiome research being presented during the conference.

As mentioned yesterday, commencement of the National Microbiome Initiative was met with great exci... Read More

Are Viruses Alive?

Plenty of people have weighed in on the question, 'Are Viruses Alive?' Here is my answer - different from all the others. Read More

BacterioFiles 255 - Colonizer Controls Carrier Cultivation

This episode: Some bacteria seem to cause slime mold amoebas to carry around other bacteria for food!


(12.4 MB, 13.5 minutes)


Show notes: 
Read More

TWiV 393: Lovers and livers

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.


Hosts:  Read More

ASM hosts Wikipedia Edit-a-thon as part of the Year of Science

“Wikipedia is the first place people go for information about science – and everything else,” says John Tracey, Research Assistant in Education & Outreach at the Simons Foundation. The Simons Foundation has teamed up with Google to sponsor the Wikipedia Year of Science 2016, an initiative to inc... Read More

Virus Watch: How Mosquitoes Spread Viruses

In this episode of Virus Watch, I explain how mosquitoes spread viruses. We’ll look at how a mosquito finds a host, how it finds a blood vessel, and how it delivers viruses to a new host. Don’t blame mosquitoes for viral diseases: it’s not their fault!

https://www.youtube.com/watch?v=7wsk8a3z... Read More

Induction of Acinetobacter baumannii natural competence

Bacteria acquire and spread genetic information through several means. Some bacteria form a long, thin tube called a pilus, mediating transfer of DNA by direct cell-to-cell contact, in a process known as conjugation. Some bacterial take up environmental DNA and incorporate it into their existing... Read More

TWiEVO 8: Everyone’s a little bit Neanderthal

Many years ago, Homo sapiens mated with Neanderthals. Today a small percentage of our genome remains Neanderthal, and in a study discussed on this episode of the science show This Week in Evolution, we show that some important genes of our innate immune response - the early response against path... Read More

TWiM #129: Dried and wrinkled, smooth and mucoid

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.


Image (right): Etest used to determin... Read More

TWiM 129 Letters

Steven writes:


Dear Vincent et al,


Firstly, congratulations for keeping up such a wide range of thought provoking podcasts, and maintaining such a tremendous output. I find they all leave me with more questions than answers, which is, I think, a sign of good s... Read More

Technological advances reveal finer details about chronic infection

How do chronic infections change over time? This is the broad question addressed in recent research published in the Journal of Virology. In their study, a team of scientists headed by Fabio Luciani investigated a hepatitis B virus infection over a course of 15 years.

Hepatitis B virus (HBV) ... Read More
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