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Getting Started with MicrobeWorld

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BacterioFiles 253 - Probiotics Promote Protective Pathway

This episode: In mice and fruit flies, Lactobacillus species induce gut cells to protect themselves from reactive oxygen compounds!


(8.2 MB, 8.9 minutes)


Show notes: 
Read More

BacterioFiles 258 - Transformed Toxin Translocates Treatments

This episode: Bacterial toxins could be modified to deliver life-saving proteins into neurons!


(11.1 MB, 12.1 minutes)


Show notes: 
Journal Paper:

Chen C, Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT. 2015.... Read More

TWiM #130: Interkingdom interactions at ASM Microbe

The TWiMers get together at ASM Microbe 2016 in Boston to speak with David and Vanessa to talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.


Hosts: Read More

BacterioFiles 256 - Virus Versus Virus

This episode: Viruses can cause host cells to inhibit other viruses!


(8 MB, 8.75 minutes)


Show notes: 
Journal Paper:

Chiba S, Suzuki N. 2015. Highly act... Read More

BacterioFiles 254 - Clostridium Consolidates Combustibles Conversion

This episode: Engineering bacteria to convert cellulose directly into useful biofuels and chemicals can be tricky!


(13.9 MB, 15.2 minutes)


Show notes: 
Read More

BacterioFiles 255 - Colonizer Controls Carrier Cultivation

This episode: Some bacteria seem to cause slime mold amoebas to carry around other bacteria for food!


(12.4 MB, 13.5 minutes)


Show notes: 
Read More

TWiM 131: Mice behaving badly

Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.


Hosts: Vinc... Read More

TWiM #129: Dried and wrinkled, smooth and mucoid

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.


Image (right): Etest used to determin... Read More

MWV 105 - Understanding the Pathogenesis of the Emerging Zika Virus

Dr. Michael Diamond, 2016 Elizabeth O. King Lecturer, has worked for the past two decades investigating how viruses work, with a goal of defining basic principles of pathogenesis and host immune restriction. His talk in this podcast focuses on how his laboratory has studied three emerging mos... Read More

TWiM #133: Right under our noses

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.


Hosts: Vincent Racaniello, Elio Schaechter, an... Read More

BacterioFiles 259 - Fluke Froth Fosters Fester Fixing

This episode: I converse with Dr. Michael Smout about a liver fluke parasite could help heal chronic wounds more quickly!


(13.4 MB, 14.6 minutes)


Show notes: 
Read More

BacterioFiles 261 - Pilfered Parasitoid Proteins Protect Prey

This episode: Viruses domesticated by parasitoid wasps have transferred wasp genes to caterpillar victims, allowing them to survive deadly infections from other viruses! This means that Monarch butterflies are effectively naturally Genetically Modified Organisms (GMOs).


(13.8 MB, 15 m... Read More

TWiP 112: A NOD to a tricky helminth

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.


Hosts:  Read More

TWiP 111: Bug bites

The TWiP trio solve the case of the bug bites all in a row, and talk about a secreted Toxoplasma protein that is central to the parasite's manipulation of host cells.


Hosts: Vincent Racan... Read More

TWiM #134: Lipids that live forever

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.


Hosts: Vincent Racaniello, Elio Schaechter,... Read More

TWiP 114: Plant potions perturb Plasmodium

The TWiP troika solve the case of the Female from the Bronx, and reveal how feeding on different plants affects mosquito capacity to transmit malaria.


Hosts: Vincent Racaniello Read More

TWiV 394: Cards in a hand

Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.


Hosts:  Read More

BacterioFiles 257 - Phage Fibers Fight Phyllosphere Foes

This episode: Bacteria have repeatedly captured and used the tails of phages to fight each other!


(9 MB, 9.8 minutes)


Show notes: 
Journal Paper:

Hockett KL, Renner T, Baltrus DA. 2015. Read More

TWiP 116: One drug to rule them all

The TWiPtoids solve the case of the Thai Fisherman with Chronic Diarrhea, and reveal a potential new drug for treatment of leishmaniasis, Chagas diseases, and sleeping sickness.


Hosts: Vincent Racaniel... Read More

TWiP 113: Flying pigs

The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella.


Hosts: Vincent Racaniello Read More

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