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TWiV 421: Like flies on shot

The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.


Hosts: Vincent Racaniello,&n... Read More

TWiV 422: Watching the icosahedron drop

The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.


Hosts: Vincent Racaniello Read More

TWiM #142: A membrane-thickness caliper

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.


Hosts:  Read More

How to be a successful food borne pathogen: step 1, grow on food

Food microbiology is an important issue we cover on this blog, because food safety is vital to prevent foodborne illness. The use of technologies like whole-genome sequencing help identify and pinpoint the source of microbial contaminants, but how do microbes become contaminants in the first pla... Read More

Microbiomes in far-flung places: characterizing the arctic Inuit gut microbiome

The hamlet of Resolute Bay is a tiny Arctic village in the Nunavut territory of Canada with a population that hovers at or below 300. Over hundreds of perhaps even thousands of years, the traditional Inuit diet in Resolute Bay and elsewhere has been dictated by the Arctic environment. The diet i... Read More

10 Things You Need to Know about mSphereDirect

mSphereDirect is an exciting new pathway to publish your research! This groundbreaking new submission path puts you in control of getting your original research reviewed and published as soon as possible. We’ve prepared the most important things to keep in mind while preparing your manuscript s... Read More

Outbreak of H7N2 Flu in Cats

Many mBiosphere readers will know that the influenza A virus infects multiple species, and this ability to infect birds, humans, and other mammals such as pigs is one of the ways virions can exchange genetic information, leading to new viruses able to cause major outbreaks. However, few mBiosphe... Read More

Flaviviruses unexpectedly shut off host translation

It was a peer review request that got Alessia Ruggieri and her group at University of Heidelberg to look more closely at how Dengue virus manipulates the cellular translation and stress machineries during infection.

In a previous study, Ruggieri showed that Hepatitis C virus infection induced... Read More

TWiV 423: Dry, well formed, and light brown

The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats.


Hosts: Vinc... Read More

Researchers Use Innovating Methods to Study Vertical Transmission of Microbes

It has been assumed that mothers pass on gut microbes to their infants during and just after delivery, a process called vertical transmission, but because of technical restraints, the evidence of this occurring has been limited. Previous cultivation-free studies have observed the same microbial ... Read More

BacterioFiles 281 - Prokaryote Partners Produce Plastic

This episode: Microbes with complementary abilities help each other grow and produce useful stuff from the air!


(12 MB, 13.2 minutes)


Show notes: 


Journal Paper:

Smith MJ, Francis MB. 2016. Read More

"What will change in Clinical Microbiology Laboratories by 2050?"

If you are lucky enough to be still alive and working in 2050... How might the clinical microbiology laboratory have changed by that time? Nobody can accurately predict the future, but here are my personal thoughts... Read More

TWiV 424: FLERVergnügen

Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.


Hosts:  Read More

Are Medical Laboratories becoming Factories?

In what ways might medical laboratories now be perceived as factories? And where does the similarity end? Read more...

Read More

Advancing Phage Therapy

New research conducted at the University of Miami in Coral Gables, Florida and the National Cancer Institute, in Bethesda, Maryland demonstrate that a subset of bacteriophages, dubbed “superspreaders,” potentially play a major role in transmitting antimicrobial resistance. The research, describe... Read More

A Microbial Death Star

Star Wars – an epic story of war between the forces of good and evil in a galaxy far, far away. The Death Star – the ultimate weapon of destruction. The story is science fiction, but it could be considered an analogy for the constant battle between our immune system and microbial pathogens. Beli... Read More

"Tricky Trichomonas"

"What is the best way to test for Trichomonas vaginalis in a cost effective manner? It's a classic trade-off between money and assay sensitivity." Read More

Emerging Pathogen Surveillance with Jonna Mazet, PhD

Jonna Mazet, PhD, UC Davis School of Veterinary Medicine, is interviewed by Vincent Racaniello, PhD, Columbia University, New York, about emerging pathogen surveillance and public health. Dr. Mazet is the Principal Investigator and Global Director of the novel viral emergence early warning proje... Read More

TWiV 425: All picornaviruses, all the time

The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection.


Hosts: Vincent Racaniel... Read More

Building an Ebola Virus Lab in Sierra Leone with Ian Goodfellow, PhD

Ian Goodfellow, PhD, Cambridge University, is interviewed by Vincent Racaniello, PhD, Columbia University, New York, about state of lab capacity in Africa during the Ebola outbreak. Goodfellow made the decision to go to Sierra Leone during the late summer of 2014 after following the media covera... Read More
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