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Viral bioinformatics: Introduction + Homology

First, you may be asking yourself – Why viral bioinformatics? Good question! Although it’s true that much in the world of bioinformatics can be applied to all manner of protein and DNA sequences, there are a number of resources that are specific for viruses and there are a number of analyses tha... Read More

PLoS Journals Projected to be 100% Self-Sufficient by 2010

The Public Library of Science's open access journals just release its 2009 June Progress Report in which they project "a publishing business model projected to be 100% self-sufficient in 2010."

"PLoS journals use a business model that recovers expenses — including administration of peer revie... Read More

TWiV 152: Viromes in the effluence of society

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Hosts: Vincent Racaniello, Al... Read More

TWiV 180 Letters

Rohit writes:


Hi Dr Racaniello,


I am a long time listener of TWIV and really enjoy the informal scientific discussions. I listen to TWIV while working in the lab and am trying to catch up on TWIM and TWIP episodes too.


I have been dill... Read More

El Podcast del Microbio Nº 169. DNA Ligasa de Mycobacterium cristalizada. (Mycobacterial DNA Ligase crystalized)



























El podcast del Microbio 169 resumes the recent Molecular Cell paper about the crystal structure of Mycobacterium tuberculo... Read More

El Podcast del Microbio Nº 174 y 175. La Historia de Alice Catherine Evans. /The Story of Alice Catherine Evans)



























El podcast del Microbio Nº174 and 175 are dedicated to Alice Catherine Evans, one of the first women microbiologists. Los ... Read More

TWiV 146 Letters

Jonathan writes:


First and foremost, this and the podcast of the virology course lectures available on iTunes is a gift to the public. I am applying to medical school and I appreciate the material on a topic I did not have time to take but have had a long standing int... Read More

Building the perfect bug

This past February I was interviewed by the Australian Broadcasting Company on the topic of the Fouchier and Kawaoka experiments on avian influenza virus H5N1. The video, Building the Perfect Bug, has been released by Journeyman Pictures and includes interviews with S.T. Lai, Laurie Garrett, Mic... Read More

TWiV 165 Letters

Justin writes:


Are you, Alan Dove and Prof. Racaniello, saying you think Mikovits and/or others on the Lombardi paper lied about the results or blinding? I think circumspection is a natural human reaction to the allegations of theft that have been made against Dr. Mik... Read More

TWiV 87 Letters

James writes:


Dear TWIV,


I've really enjoyed hearing about the paths you and your guests took to enter the fields of virology and parasitology.


I was wondering if Dr. Dove could talk for a few minutes about how and why he decided to transition into sci... Read More

10 Genes, Furiously Evolving

This is a great article by Carl Zimmer in the NY Times (@carlzimmer on Twitter) about the evolution process of viruses.

"Some viruses use DNA, like we do, to encode their genes. Others, like the influenza virus, use single-strand RNA. But viruses all have one thing in common, said Roland Wolk... Read More

TWiV 120 Letters

Ashley writes:


Vincent, I am a huge fan of TWIV and thank you and the others for taking time out of your busy schedule to do the program. I have my B.S. in Biology and Chemistry and would love to go back to school. I read textbooks, listen to podcasts from itunesU and... Read More

The Rise of Genomic Superspreaders

One hundred million years ago the earth’s climate was much warmer than today and vast inland seas stretched across entire continents. The land was dominated by charismatic megafauna that would one day serve as inspiration for Sir Arthur Conan Doyle’s novel The Lost World. This period is commonly... Read More

TWiV 163 Letters

Ronnie writes:


Hello Professor Vincent,


First of all, thank you for your wonderful podcasts! I'm a CFS sufferer and also a student Applied Science so I'm interested in many of the topics discussed for those two reasons and always learning new things.


I... Read More

TWiV 162 Letters

Sarah writes:


Hello to the TWiV crew,


Here are a couple of picks I thought would be good for provoking thought and generating discussion...


While working on a project, I came across some papers attempting to define what "critical thinking" means. I app... Read More

Podcast del Microbio Nº190 y 191. El Cuarto Dominio (The Fourth Domain)



























El podcast del Microbio Nº190 and 191 describes the recent metagenomic results that point towards the existence of a 4th do... Read More

Norton Zinder, 1928-2012

Norton Zinder made two important discoveries in the field of virology. While a Ph.D. student with Joshua Lederberg at the University of Wisconsin-Madison he found that viruses of bacteria (bacteriophages) could move genes from one host to another, a process called transduction. Later in his own ... Read More

TWiV 159 Letters

Jenny writes:


Hi Vince and the rest of the TWIV-cast!


You might have come across this news already, but it would be interesting to hear the TWIV gang's take on this study done by Fouchier's group from the Netherlands.


Read More

Genome Wide Manipulation of the Bacterial Chromosome in Vivo

On the Small Things Considered blog, Michael Schmidt, Professor and Vice Chairman of Microbiology and Immunology at the Medical University of South Carolina, reviews a recent paper entitled "Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement" by Church and colleagu... Read More

What Happened to Our Friendly Enterococci?

Enterococci had been generally regarded as benign commensals, a part of our healthy intestinal microbiota. They were even invited in, being used as probiotics. But then, in the late 1970s, the first multiple drug-resistant strains appeared, and vancomycin-resistant strains followed in 1981. In r... Read More

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