The third annual installment of my virology course at Columbia University, Biology W3310, has begun, and all the lectures will be available online. Read More
A dairy cow in California is the fourth known American case of mad cow disease, which is caused by prions, infectious agents composed only of protein (the story hit the press the day after my lecture on this type of illness). Unlike viruses, prions have no nucleic acid and no protective coat. Bu... Read More
A salt-loving (halophilic) bacterium which can grow in medium containing arsenic instead of phosphorus has been selected from the microbial community of Mono Lake in California. Arsenic (As) is a chemical analog of phosphorus and is usually toxic because it can enter metabolic pathways in the pl... Read More
A type of human encephalitis – an infection of the brain – has been known to affect the indigenous people living in the Sakha Republic of Russia since the mid-1800s. The available clinical and epidemiological evidence suggests that the disease is caused by a pathogen, but proving this has been d... Read More
Hello Professor Vincent,
First of all, thank you for your wonderful podcasts! I'm a CFS sufferer and also a student Applied Science so I'm interested in many of the topics discussed for those two reasons and always learning new things.
I... Read More
A team of researchers from The Wistar Institute has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C, and hepatitis B, as well as s... Read More
Jamie Henzy, a postdoctoral researcher at Boston College, has authored a post on Small Things Considered that explores the shady world of the deltaretrovirus genus.
"Among retroviruses, the deltaretrovirus genus is something of a shady bunch, its members lurking in the shadows, causing troubl... Read More
Hello to the TWiV crew,
Here are a couple of picks I thought would be good for provoking thought and generating discussion...
While working on a project, I came across some papers attempting to define what "critical thinking" means. I app... Read More
When infection with hepatitis C virus goes from acute to chronic, severe liver disease may occur which requires organ transplantation. Nearly 200 million people are chronically infected with HCV, necessitating approaches to preventing and treating infections. No HCV vaccine is available, and cur... Read More
I have heard recently that some types of herpes virus may protect us from bacterial infections. This made me remember of myxomavirus, viral oncotherapy and how tumor cells have a compromised immune response. Do you think it is possi... Read More
A second virophage has been identified. The name does not signify a virus that infects another virus – it means virus eater.
There is an excellent question in the comments to “Are all virus particles infectious?“: if the particle-to-PFU ratio for a virus stock is 10,000:1, and I infect 1,000,000 cells with 10,000 particles, how many plaques would I expect to observe? Answering this question provides insight into the p... Read More
The virologists who carried out the contentious experiments on influenza H5N1 transmission in ferrets have agreed to remove certain details from their manuscript, according to ScienceInsider. This is a bad day for virology, and for science in general. The decision by the NSABB sets a precedent f... Read More
Science writer Carl Zimmer writes a masterful blog piece tracing the history of the study of ecosystems, from lakes to the human microbiome. Just one interesting fact: In their lifetimes, individual humans will produce about five elephants worth of microbes. Read More
On the Small Things Considered blog, Michael Schmidt, Professor and Vice Chairman of Microbiology and Immunology at the Medical University of South Carolina, reviews a recent paper entitled "Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement" by Church and colleagu... Read More
This is a great article by Carl Zimmer in the NY Times (@carlzimmer on Twitter) about the evolution process of viruses.
"Some viruses use DNA, like we do, to encode their genes. Others, like the influenza virus, use single-strand RNA. But viruses all have one thing in common, said Roland Wolk... Read More
The finding of viral nucleic acid sequences in illegally imported wildlife products has attracted the attention of the New York Times, which published an article entitled From the jungle to J.F.K., viruses cross borders in monkey meat. Read More
This past February I was interviewed by the Australian Broadcasting Company on the topic of the Fouchier and Kawaoka experiments on avian influenza virus H5N1. The video, Building the Perfect Bug, has been released by Journeyman Pictures and includes interviews with S.T. Lai, Laurie Garrett, Mic... Read More
Elio Schaechter of Small Things Considered has authored an interesting post today about the motility of bacteria, specifically Paenibacillus, although he does highlight several other strains that swarm, glide or twitch.
"Microbes get around. They can be carried by the wind, by insects, or by ... Read More
Enterococci had been generally regarded as benign commensals, a part of our healthy intestinal microbiota. They were even invited in, being used as probiotics. But then, in the late 1970s, the first multiple drug-resistant strains appeared, and vancomycin-resistant strains followed in 1981. In r... Read More