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A system‐level model for the microbial regulatory genome

Microbes can tailor transcriptional responses to diverse environmental challenges despite having streamlined genomes and a limited number of regulators. We present data‐driven models that capture the dynamic interplay of the environment and genome‐encoded regulatory programs of two types of prok... Read More

El podcast del microbio Nº250. Cómo hacer un virus letal en cinco pasos (How to make a lethal virus in five steps)



























"El podcast del microbio" Nº 250 summarize the article published in November by New Scientist about the controversial work on mu... Read More

TWiV 265: This year in virology



Hosts: Vincent Racaniello, Alan Dove Read More

El podcast del microbio Nº157: "El Tercer Hombre" en el siglo XXI. ("The Third Man" in XXI Century). 1º Part



























El Podcast del Microbio" Nº 157 : First part of the story of ex-doctor A. Wakefield, the new "Harry Lime", responsible of t... Read More

HIV gets the zinc finger

Because all animal viruses initiate infection by binding to a receptor on the cell surface, this step has long been considered a prime target for antiviral therapy. Unfortunately, drugs that block virus attachment to cells have never shown much promise. Another approach, which is to ablate the r... Read More

WHO will switch to type 2 inactivated poliovirus vaccine

The World Health Organization’s campaign to eradicate poliomyelitis made impressive inroads in 2012: only 212 cases were reported, compared with 620 the previous year; moreover, India remained polio-free. The dark side of this story is that as wild polio is eliminated, vaccine-associated poliomy... Read More

TWiV special: MERS-coronavirus in dromedary camels



Host: Vincent Racaniello


Guests: Read More

Virus-induced fever might change bacteria from commensal to pathogen

Neisseria meningitidis may cause septicemia (bacteria in the blood) and meningitis (infection of the membrane surrounding the brain), but the bacterium colonizes the nasopharynx in 10-20% of the human population without causing disease. Although understanding how the bacterium changes from a com... Read More

Poliovirus on Time

Poliovirus has made the cover of Time magazine. The Time cover image for the 14 January 2013 issue is a model of poliovirus bound to a soluble form of its cellular receptor, CD155. I was part of the team that solved the structure of this complex in 2000, together with the laboratories of Jim Hog... Read More

Viruses on Time

Poliovirus recently made the cover of Time magazine. Prompted by a reader question, I searched the Time archive to find out if there have been other virology-themed covers. I found fifteen in all, depicting poliovirus (3), herpesvirus (1), HIV/AIDS (4), influenza (5), and SARS coronavirus (2) (I... Read More

TWiP 66 letters

 


Andre writes:


Dear Vincent,


To my great delight, I just discovered your podcasts twiv, twim and twip.


The first twip I heard, about Strongyloides stercoralis, although informative and interesting, seemed to have several inaccuracies. I w... Read More

Men More Likely to Commit Research Misconduct than Female Counterparts #mBio #science

It’s not hard to see that men are more likely to engage in risky behaviors than women, or that crime rates are many times higher among men, but this tendency to break the rules also extends to male scientists, according to a study to be published on January 22 in mBio®, the online open-access jo... Read More

Antibiotics work against viruses

Got your attention, eh? This page discusses why so many people believe that antibiotics kill viruses, and what you can do about that myth. Actually, it's not even a myth ... antibiotics DO work against viruses. The problem is that the word "antibiotics" is redefined by some to be a synonym of... Read More

Harvard University: Great virology, bad science writing

Harvard University is home to some of the world’s finest virologists. But apparently they do not communicate with the writers at Harvard Magazine, where a botched story on the avian H5N1 influenza virus has just been published. Read More

El Podcast del Microbio Nº 104: Fusarium, un modelo de hongo patógeno



























In the Nº 104 of the "El podcast del microbio" I resume the recent findings on pathogenesis by Fusarium. En "El podcast del microbio" Nº 104 ... Read More

Bashing Botulism: Scientists Sleuth World’s Most Powerful Toxins

The May Issue of Agricultural Research published by the USDA-ARS contains several stories about microbes involved in everything from anthrax to zoonoses—diseases that can spread from animals to people.

One story that I found interesting is on the research being done to faster identify and de... Read More

How to give a great lecture

There are many elements that go into making a great lecture, but the most important one is to lose the notes. If you are giving lectures in a course at any level, the worst practice you can engage in is to rely on notes. This behavior is problematic for several reasons. You will not properly kno... Read More

Friday flu shot

Yesterday many US newspapers carried front-page stories on the severity of influenza so far this season. The New York Times story began with “It is not your imagination — more people you know are sick this winter, even people who have had flu shots.” Is this really a bad flu season? Read More

Where They’re Found


Archaea comes from the Greek word meaning “ancient.” An appropriate name, because many archaea thrive in conditions mimicking those found more than 3.5 billion years ago. Back then, the earth was still covered by oceans that regularly reached the boiling point ... Read More

TWiP 65 letters

 


Perry writes:


Greetings Vincent and Dick,


Hooray for finally mentioning G. pulchrum in episode 62, my most favorite parasite and one worthy of further discussion. As a diagnostic veterinary pathologist, I encounter this spirurid in approximately... Read More

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