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Genes, malevolent and beneficial pathogens and autoantibodies in HIV-1/AIDS

Certain viral infections are known to increase or decrease HIV-1 replication or viral load, perhaps by competing with the same receptors, or via immune and other effects.Many autoantibodies in HIV-1 infection also target the immune network and this may well contribute to pathology. Read More

Transgenic mice susceptible to poliovirus

Yesterday I terminated the last remaining mice in my small colony, including the line of poliovirus receptor transgenic mice that we established here in 1990. Remarkably, I had never written about this animal model for poliomyelitis which has played an important role in the work done in my labor... Read More

TWiM #11: Chickens, antibiotics, and asthma

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Hosts: Vincent Racaniello, Read More

TWiM 11 Letters

Steve writes:


As a microbiologist I enjoy listening to your broadcasts.  However, I was very disappointed on the one about Salomonella in cantaloupe and E. coli O157:H7 in Lebanon bologna.  Many incorrect statements were made, such as "Salmonella enteritidis is th... Read More

Viruses that Infect Parasites that Infect Us: The Matryoshka Dolls of Human Pathogens

"We’re all too familiar with the viruses that can infect us, from the common cold to yellow fever virus to the endogenous retroviruses that make up a chunk of our genome. Many of us are also acquainted with parasites, such as tape worms or Giardia, that like to set up camp in the human body. But... Read More

All You Want to Know About Fungal Pathogens & Protozoan Parasites - at Keystone Symposia in Santa Fe, January 2012

Save the date for Keystone Symposia's meeting on "Fungal Pathogens: From Basic Biology to Drug Discovery" to be held January 15-20, 2012 at the Santa Fe Community Convention Center in Santa Fe, New Mexico. Organized by Joseph Heitman of Duke University, John Taylor of UC Berkeley and Leah E. Cow... Read More

Lyme borreliosis in Europe

Despite improvements in prevention, diagnosis and treatment, Lyme borreliosis (LB) is still the most common arthropod-borne disease in temperate regions of the northern hemisphere, with risk of infection associated with occupation (e.g. forestry work) and certain outdoor recreational activities ... Read More

AmicBase: Database of Antimicrobials

Detailed antibiotic inhibitory data of licensed drugs on the major markets of Europe, Japan and USA is now available in one database on the internet. The database is named AmicBase Drugs-Online 2011 and is published for information and educational purposes. This service is free. Click source to ... Read More

Happy as a clam? Maybe not.

The expression “Happy as a Clam” comes with new meaning as hepatitis A virus has been detected in clams, mussels, and oysters in markets for human consumption. As bivalve shellfish are excellent bio-accumulators of contaminants and chemicals, it is no surprise that they also harbor waterborne vi... Read More

TWiV 141: Mickey gets HCV

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Hosts: Vincent Racaniello, Rich Condit, Read More

TWiV 141 Letters


Lance writes:


Many thanks to all of you for such an excellent podcast. I think you all do a really fantastic job. As an ID physician and postdoctoral researcher working on flavivirus immunology in my case you are "preaching t... Read More

BacterioFiles Micro Edition 46 - Better Bacterial Bioplastic

This episode: Making bioplastic with industrial exhaust gas!


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Propose a Topic for asm2012 - 112th General Meeting of ASM

Are you interested in proposing an interdisciplinary topic with maximum appeal? Do you have an idea for a core colloquium or symposium of scientific significance? ASM's General Meeting Program Committee is soliciting suggestions to help build the program for asm2012 in San Francisco, June 16-1... Read More

Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade

Using genetic dissection and photothermal nanoblade delivery, a recent paper published in PNAS by Jeff F. Miller, MD., Chair, Microbiology, Immunology, & Molecular Genetics, UCLA, and others, presents data that suggest that the primary means for intercellular spread of Burkholderia pseudomallei ... Read More

How We Tell The Good Bacteria From The Bad

Recently, Yale’s Richard Flavell led a team of researchers into the most talked about and yet one of the least understood of microbial environments—the human gut. Rather than present the usual metagenomic characterization of the microbial population, he teamed up with Jeff Gordon at Washington U... Read More

BacterioFiles Micro Edition 45 - Partners Produce Prion-Pulverizing Proteins

This episode: Some lichens can degrade environmental prions!


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TWiV 140: An aptitude for microbicides

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Hosts: Vincent Racaniello, Alan Dove, Read More

TWiV 140 Letters

from @Lafrenchfille on Twitter:


French listen to your very cool podcast. So I can confirm, "Mimi" is french !


Peter writes:


Regarding the podcasting advice from the fellow in Israel.


Explain st... Read More

Poliomyelitis after a twelve year incubation period

Analysis of poliovirus recovered from the stool of a patient with fatal poliomyelitis revealed that she had been infected with the virus 12 years earlier, probably when one of her children received the oral poliovirus vaccine. This case has the longest known incubation period for vaccine-derived... Read More

July 2011 Microbe Feature article

In this month's Microbe magazine, now online,Janet Jannson, a Professor and Senior Staff Scientist in the Ecology Department, Earth Sciences Division, of Lawrence Berkeley National Laboratory explains how microbial ecologists are taking a metagenomics approach to analyze complex and diverse soil... Read More
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