A referenced interactome of host genes and proteins affected by the Bornavirus. KEGG pathways of the host arm of the interactome are also linked from the interactome page. If you have any data to add please use the email link on the page and I will update the various pathways. Read More
Until we have "action figures" of scientists, I do what I can to recognize scientists that have had a large and lasting influence on my academic career. In this blog post, I praise Dr. Moselio Schaechter for his clear and insightful approaches to microbiology. His enthusiasm, breadth of interes... Read More
I am a big believer that different pedagogical approaches can "reach" different students. In most of my classes, I give students an optional assignment: come up with a creative project that explores some aspect of class. This takes several steps. First, I make the students come up with an ide... Read More
In this blog post (and fourth "Mu-Tube" video), I explore the idea that all animals and plants have evolved as part of a microbial world, and thus microbes are a part of us. I do this by having my undergraduate students explore two recently publications by Dr. Margaret McFall-Ngai,and recording... Read More
About eight percent of human DNA is viral: it consists of retroviral genomes produced by infections that occurred many years ago. These endogenous retroviruses are passed from parent to child in our DNA. Some of these viral genomes are activated for a brief time during human embryogenesis, sugge... Read More
Hurricane Matthew hit Haiti on October 4, 2016, and the southeast United States two days later, leaving tens of thousands without power, transportation, and in the worst cases, homes. Because of its extreme poverty, and its continuing recovery from previous natural disasters, Haiti is looking at... Read More
Segmented genomes abound in the RNA virus world. They are found in virus particles from different families, and can be double stranded (Reoviridae) or single stranded of (+) (Closteroviridae) or (-) (Orthomyxoviridae) polarity. Our recent discussion of the advantages of a segmented viral genome,... Read More
Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecules can be involved, and labeling with small molecules, such as fluorescent dyes, biotin, and other groups can be readily achieved.
Click chemistry reaction takes pl... Read More
There are countless examples of plant, animal and bacterial viruses that cause severe symptoms of disease, sometimes with considerable socio-economic consequences. Viruses of fungi, otherwise known as ‘mycoviruses’, infect many medically and commercially important fungi, including the brewers an... Read More
Virologist Richard Elliott passed away on 5 June 2015. I have known Richard since 1979 and I would like to provide some personal recollections of this outstanding virologist. A summary of his work can be found at the MRC-University of Glasgow Centre for Virus Research science blog. Read More
Microbial infection is implicated in an ever-growing number of types of cancer. Adding to the already long list of microbial-associated cancers, an increasing body of evidence suggests breast cancer may also be associated with a specific microbial milieu. A report in Applied and Environmental Mi... Read More
Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.
Hosts: Read More
Many microbes live in extreme environments, encountering conditions that are very hot, very cold, highly acidic, or very salty. The viruses that infect such microbes must also be able to retain infectivity in extreme conditions. How do they do it?
Clues come from the observations that the gen... Read More
A new study delineates a sequential pattern of changes in the intestinal microbial population of patients recovering from cholera in Bangladesh, findings that may point to ways of speeding recovery from the dangerous diarrheal disease. The report also finds what appear to be consistent differenc... Read More
Mineral coatings on sand particles actually encourage microbial activity in the rapid sand filters that are used to treat groundwater for drinking, according to a paper published ahead of print in Applied and Environmental Microbiology. These findings resoundingly refute, for the first time, the... Read More
I made this video in October of 2015, with my Biology 350 Microbiology students at the University of Puget Sound. A drop of Pseudomonas syringae expressing ice nucleation protein hits supercooled pure water, and fun results. This is the way that Snomax works to commercially generate snow, inci... Read More
As part of my freshman writing seminar in the Fall of 2014, I was fortunate to have a number of fascinating experts in symbioses and parasitism be willing to "televisit" my students. Here is Dr. Rob Dunn of North Carolina State University, discussing his laboratory's work with Demodex face mite... Read More
When Antonio Gonzalez began doctoral studies in Rob Knight’s laboratory, then at University of Colorado, Boulder, the computer scientist quickly learned about microbes and their connection to human health. He soon found a connection to his wife’s health jumping out of the literature at him.
H... Read More
Immunology Explained Through Poetry - What happens when one touches a poison ivy?
Billy was at summer camp,
And wanted to feel like a champ,
So he searched for a flower,
That would stop Susie’s glower,
But found poison ivy instead.
While Billy was later playing,
He had no i... Read More