A recent study by scientists at the Ludwig Center for Cancer Immunotherapy offers a new, multifaceted therapy for destroying tumors. A team of researchers led by Dmitriy Zamarin combined checkpoint blockade, a technique aimed at enhancing antitumor immune responses, with oncolytic viral therapy,... Read More
This episode: Bacteria in the gills of fish help break down their metabolic wastes before they reach toxic levels!
(7.4 MB, 8.1 minutes)
PLOS ONE authors Cybulski, Clements and Prakash describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume f... Read More
Viruses can be broadly classified according to whether or not the particle is enveloped – surrounded by a membrane taken from the host cell – or naked. Some naked viruses apparently are more modest than we believed. Read More
This episode: Slime molds have special cells that capture and kill bacteria using traps made of DNA!
(11.2 MB, 12.25 minutes)
"Hivi and his team of viruses (Ebola, Pox,..etc) believe they can win the battle, but the Virologists (who are real famous professors) beat them. However, new viruses pop-up, it will be a long battle. This makes the story very interesting and ever so engaging."
ACKNOWLEDGMEN... Read More
Wild poliovirus has been detected in the sewers of Brazil and Israel. Fortunately, no cases of poliomyelitis have been reported in either country. Why is poliovirus present in these countries and what are the implications for the eradication effort?
Wild type poliovirus (e.g. not vaccine-deri... Read More
Unknown fungi isolated from soil sample.I would like to have inputs from the Mycologist in the forum about this fungal colony,its identification,name,species and genus? Read More
Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.
Genomes of non-defective viruses range in size from 2,400,000 bp of dsDNA (Pandoravirus salinus) to 1,759 bp of ssDNA (porcine circovirus). Are even smaller viral genomes possible? The subviral agents called viroids provide an answer to this question.
Viroids, the smallest known pathogens, ar... Read More
The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon was found to contaminate other cell lines. Now HeLa RNA has made its way into human sequence dat... Read More
This study investigates how the overexpression of a specific ORF affects the virulence of E. faecalis. Read More
In this blog post, I describe how I use the commonly available pGLO plasmid to teach freshman students basic concepts about transformation, receptor recognition, drug resistance mechanisms, and gene regulation. Oh, and fluorescence via GFP! Read More
How do chronic infections change over time? This is the broad question addressed in recent research published in the Journal of Virology. In their study, a team of scientists headed by Fabio Luciani investigated a hepatitis B virus infection over a course of 15 years.
Hepatitis B virus (HBV) ... Read More
Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More
Two vaccines against Zika virus developed at the University of Pittsburgh School of Medicine have successfully conveyed immunity from female mice to pups conceived weeks after the mother's vaccination.
When challenged with Zika virus within a week of their birth, both vaccines protected the p... Read More
In this blogpost, I celebrate the microbiological season with some microbial merriment: ice nucleation bacteria, drawing with reporter gene bacteria, and painting with bioluminescent microbes. Every day is Luxmas to me! Read More
Follow the reconstruction and simulation of poliovirus using the BlueGene/Q supercomputer at the Victorian Life Sciences Computation Initiative. The poliovirus model is being used as a basis for understanding antiviral drugs, virus infection and helps us to learn how to model related viruses suc... Read More
A referenced interactome of host genes and proteins affected by the Bornavirus. KEGG pathways of the host arm of the interactome are also linked from the interactome page. If you have any data to add please use the email link on the page and I will update the various pathways. Read More
The thousands of survivors of the Ebolavirus outbreak in western Africa – more than at any other time – are fortunate to have survived the disease. However, their health problems are not behind them. A new study shows that the survivors of Ebolavirus have long-term sequelae more than 2 years aft... Read More