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MWV Episode 94 - TWiM #99: Careers in Biodefense
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Infectious agents with no genome

If the reader does not believe that viroids and satellites are distinctive, then surely prions, infectious agents composed only of protein, must impress.

The question of whether infectious agents exist without genomes arose with the discovery and characterization of infectious agents associat... Read More

TWiM 100 Letters

Matt Daugherty writes:


I just listened to the latest TWiM. Thanks for covering our horizontal gene transfer paper! It was great to hear you all talk about it and give your thoughts.


With regards to the selective pressure for retention of the Dae’s in genomes o... Read More

My First Radio Interview About Teaching, Research, and Microbial Supremacy...

The great folks at "The People Behind the Science" interviewed me over Skype in late July, and the interview has just been released as a podcast. I discuss my path through science, my thoughts on teaching, research at undergraduate institution, and how to motivate and inspire students to strive... Read More

Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate

Wine grapes present a unique biogeography model, wherein microbial biodiversity patterns across viticultural zones not only answer questions of dispersal and community maintenance, they are also an inherent component of the quality, consumer acceptance, and economic appreciation of a culturally ... Read More

Social Media, Course Syllabi, and Blowing Off Steam...

In this post from my blog, I discuss the recent interest in snarky-funny academic hashtags on Twitter, such as #overlyhonestsyllabi. Just like students, educators need to blow off some steam (especially as classes approach!). But it is also important to remember our educational goals, and matc... Read More

Where Biology and Art Work Together in the Classroom

In this blog entry, I describe how working with the artist Katie McKissick ("Beatrice the Biologist") helped improve my freshman biology course. The intersection of biology and art benefits both! Read More

Influenza A viruses in bats

It is well known that aquatic birds are a major reservoir of influenza A viruses, and that pandemic human influenza virus strains of the past century derive viral genes from this pool. The recent discovery of two new influenza A viruses in bats suggests that this species may constitute another r... Read More

Pet rats as a source of hantavirus in England and Wales

Researchers report the detection of a strain of Seoul hantavirus (SEOV) in pet rats in England and Wales. The discovery followed an investigation of a case of haemorrhagic fever with renal syndrome in Wales. Hantavirus RNA was detected via real-time reverse transcription-polymerase chain reactio... Read More

ASM GM 2014 - Bacteria in Urine Could Cause Overactive Bladder

Contrary to popular belief, urine is not sterile and the bacteria in it may be associated with overactive bladder (OAB) in some women. Presenters will discuss their research ... Read More

Virology question of the week

On the science show This Week in Virology we receive many questions and comments, which are read every week. I also get many questions here on virology blog, which I tend to answer by email. However I think that everyone could benefit from these questions, so I’ve decided to post one here each w... Read More

The Black Sheep of Microbe Family

Pleasing view-Microvista. Read More

Viral genomes in 700 year old caribou scat

Recovering viral genomes from ancient specimens can provide information about viral evolution, but not many old nucleic acids have been identified. A study of 700 year old caribou feces reveals that viruses can be protected for long periods of time – under the right conditions. Read More

C. difficile Vaccine Proves Safe, 100 Percent Effective In Animal Models

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
... Read More

TWiV 328: Lariat tricks in 3D

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

How to use Fluorescent dyes or Click Chemistry in research

Protocols and free how to advice from Lumiprobe on how to use Fluorescent dyes, Click Chemistry reagents, Life Science
-Click-chemistry labeling of oligonucleotides and DNA.
-NHS ester labeling of amino biomolecules.
-SYBR Green I staining of DNA in gels.
-qPCR with SYBR Gree... Read More

Mothers' Day, Marcus Aurelius, and Microbiology.

On this Mothers' Day, I reflect on the role my late mother had on my own decision to become a scientist. We all owe are mothers a great deal, and not just for the mitochondria! So hurray for mothers everywhere! Read More

Changing influenza virus neuraminidase into a receptor binding protein

The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of the influenza virus particle serve distinct functions during infection. The HA binds sialic acid-containing cellular receptors and mediates fusion of the viral and cell membranes, while the NA removes sialic acids from glycoproteins.... Read More

World Polio Day

As a virologist who has worked on poliovirus since 1979, I would be remiss if I did not note that today, 24 October, is World Polio Day. World Polio Day was established by Rotary International over a decade ago to commemorate the birth of Jonas Salk, who led the first team to develop a vaccine a... Read More

Supercomputer Modelling of a Complete Human Viral Pathogen: Poliovirus (Polio virus)

Follow the reconstruction and simulation of poliovirus using the BlueGene/Q supercomputer at the Victorian Life Sciences Computation Initiative. The poliovirus model is being used as a basis for understanding antiviral drugs, virus infection and helps us to learn how to model related viruses suc... Read More

How influenza virus infection might lead to gastrointestinal symptoms

Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also have gastrointestinal symptoms such as vomiting and diarrhea. In mice, intestinal injury occurs in the absence of viral replication, and is a consequence of viral depletion of the gut... Read More
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