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TWiEVO 8: Everyone’s a little bit Neanderthal

Many years ago, Homo sapiens mated with Neanderthals. Today a small percentage of our genome remains Neanderthal, and in a study discussed on this episode of the science show This Week in Evolution, we show that some important genes of our innate immune response - the early response against path... Read More

Stability of MERS Under Different Environmental Conditions (research)

The stability of Middle East respiratory syndrome coronavirus (MERS-CoV) was determined at 20°C – 40% relative humidity (RH); 30°C – 30% RH and 30°C – 80% RH. MERS-CoV was more stable at low temperature/low humidity conditions and could still be recovered after 48 hours. During aerosolisation of... Read More

Overexpression of Enterococcus faecalis elr operon protects from phagocytosis

This study investigates how the overexpression of a specific ORF affects the virulence of E. faecalis. Read More

Foldscope: Origami-Based Paper Microscope

PLOS ONE authors Cybulski, Clements and Prakash describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume f... Read More

Covering up a naked virus

Viruses can be broadly classified according to whether or not the particle is enveloped – surrounded by a membrane taken from the host cell – or naked. Some naked viruses apparently are more modest than we believed. Read More

Dispatches from ASM Microbe - Saturday

Welcome back to Dispatches from ASM Microbe! Today we’ll continue Microbe 2016 highlights of the microbiome, focusing on the non-human microbiome research being presented during the conference.

As mentioned yesterday, commencement of the National Microbiome Initiative was met with great exci... Read More

Happy Birthday to a Microbial Hero™---Moselio Schaechter!

Until we have "action figures" of scientists, I do what I can to recognize scientists that have had a large and lasting influence on my academic career. In this blog post, I praise Dr. Moselio Schaechter for his clear and insightful approaches to microbiology. His enthusiasm, breadth of interes... Read More

Implications of finding poliovirus in sewers of Brazil and Israel

Wild poliovirus has been detected in the sewers of Brazil and Israel. Fortunately, no cases of poliomyelitis have been reported in either country. Why is poliovirus present in these countries and what are the implications for the eradication effort?

Wild type poliovirus (e.g. not vaccine-deri... Read More

Surprise in Lab

Unknown fungi isolated from soil sample.I would like to have inputs from the Mycologist in the forum about this fungal colony,its identification,name,species and genus? Read More

Breathing New Life into DNA Microarrays

DNA microarrays are widely used in biological research and were once thought to be a very promising gene discovery tool. However, since the advent of next generation DNA sequencing, the popularity of DNA microarrays has steadily declined. Compared to the sequencing, microarray behavior is unce... Read More

Let It (Microbially) Snow...

I made this video in October of 2015, with my Biology 350 Microbiology students at the University of Puget Sound. A drop of Pseudomonas syringae expressing ice nucleation protein hits supercooled pure water, and fun results. This is the way that Snomax works to commercially generate snow, inci... Read More

Viroids, infectious agents that encode no proteins

Genomes of non-defective viruses range in size from 2,400,000 bp of dsDNA (Pandoravirus salinus) to 1,759 bp of ssDNA (porcine circovirus). Are even smaller viral genomes possible? The subviral agents called viroids provide an answer to this question.

Viroids, the smallest known pathogens, ar... Read More

BDP FL maleimide - BODIPY analog - fluorescent labeling of proteins

BDP FL maleimide
http://www.lumiprobe.com/p/bodipy-fl-maleimide

BDP FL maleimide is a bright and photostable thiol-reactive dye for protein labeling, an ideal replacement for fluorescein for microscopy. BDP FL is a borondipyrromethene dye which has absorption and fluorescence spectra similar... Read More

Sushi protects mosquitoes from lethal virus infections

As far as I know, mosquitoes do not eat sushi. But mosquito cells have proteins with sushi repeat domains, and these proteins protect the brain from lethal virus infections. Read More

HeLa RNA is everywhere

The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon was found to contaminate other cell lines. Now HeLa RNA has made its way into human sequence dat... Read More

Teaching Freshmen about Transformation, Drug Resistance, and Gene Regulation!

In this blog post, I describe how I use the commonly available pGLO plasmid to teach freshman students basic concepts about transformation, receptor recognition, drug resistance mechanisms, and gene regulation. Oh, and fluorescence via GFP! Read More

Study reveals intestinal bacteria succession during recovery from cholera in Bangladesh

A new study delineates a sequential pattern of changes in the intestinal microbial population of patients recovering from cholera in Bangladesh, findings that may point to ways of speeding recovery from the dangerous diarrheal disease. The report also finds what appear to be consistent differenc... Read More

MERS-CoV genome found in dromedary camels

Middle Eastern respiratory syndrome coronavirus (MERS-CoV), first identified in the fall of 2012 in a Saudi Arabian patient, has since infected over 160 individuals, causing 71 deaths. Identifying the source of infection is important for efforts to prevent further infections. Recently two studie... Read More

A Bornavirus / host interactome

A referenced interactome of host genes and proteins affected by the Bornavirus. KEGG pathways of the host arm of the interactome are also linked from the interactome page. If you have any data to add please use the email link on the page and I will update the various pathways. Read More

Attenuated influenza vaccine enhances bacterial colonization of mice

Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More
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