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An unexpected benefit of inactivated poliovirus vaccine

The polio eradication and endgame strategic plan announced by the World Health Organization in 2014 includes at least one dose of inactivated poliovirus vaccine (IPV). Since 1988, when WHO announced the polio eradication plan, it had relied exclusively on the use of oral poliovirus vaccine (OPV)... Read More

Acute flaccid paralysis of unknown etiology in California

In February 2014 I wrote about children in California who developed a poliomyelitis-like paralysis, also called acute flaccid paralysis or AFP. However, the cause of this paralysis was not known. The CDC has released its study of these cases and concludes “The etiology of AFP with anterior myeli... Read More

Maybe they're born with it: intrinsic antibiotic resistance

Several recently published mBio studies describe new mechanisms of intrinsic antibiotic resistance. These mechanisms may themselves become therapeutic targets to broaden the application of currently available drugs. Read More

Viral Supercomputer Simulations

Jason Roberts, a virologist at the Victorian Infectious Disease Reference Laboratory in Melbourne, Australia, creates three-dimensional simulations of viruses showing how the molecules that make up the capsid and genome might move in very short periods of time. I visited Jason in his laboratory ... Read More

Memory loss caused by a virus

Well you may ask what virus ?

and I tell you West Nile Virus ( but I want to change it to WNV ). Every year when mosquito season arrives it will bring a lot of diseases . one of them is the memory loss. you may ask how does memory loss concern WNV?
THE ANSWER:

Thousands of people are liv... Read More

New Academy Report on Microbes of the Built Environment

This past fall, experts gathered at an American Academy of Microbiology Colloquium in Washington, D.C. to discuss an important topic relevant to many parts of society: the microbiology of built environments. A summary of the experts’ answers to important questions surrounding this topic is now a... Read More

Bacterial Messages From Beyond?

H.P. Lovecraft fan and composer Reber Clark (https://reberclark.bandcamp.com/) collaborated with my undergraduate student Ruth Isenberg and myself on a science+music+HPL video. When a log phase culture of Photobacterium leignothi is poured into a Petri dish, and 10 second exposures are taken ev... Read More

In search of a better diagnostic assay for emerging fungal pathogen Candida auris

Misdiagnosis can lead to severe consequences for patients, and is a serious clinical issue. The newly emerging Candida auris requires higher doses of antifungal medications to treat an infection than does C. albicans, highlighting the importance of proper diagnosis. Thus far, the most accurate d... Read More

Connecting the Food Supply and Urinary Tract Infections

An Applied and Environmental Microbiology study found ubiquitous contamination of chicken products in the United States with clinically relevant E. coli strains, which has implications for urinary tract infection transmission. A new book from ASM Press describes UTIs in detail, from virulence me... Read More

Disarming a pathogen's ability to cause disease

The anaerobic, Gram-positive Clostridium difficile is a big problem. It causes rampant diarrhea and tissue necrosis, with more than 150,000 annual cases in the United States alone. Many of the disease manifestations of C. difficile are mediated by two exotoxins that C. difficile produces: TcdA a... Read More

TWiEVO 8: Everyone’s a little bit Neanderthal

Many years ago, Homo sapiens mated with Neanderthals. Today a small percentage of our genome remains Neanderthal, and in a study discussed on this episode of the science show This Week in Evolution, we show that some important genes of our innate immune response - the early response against path... Read More

Small RNAs regulate Bacteroides nutrient use

Just like you and me, bacteria have ‘favorite’ foods – though in the case of bacteria, 'favorite' translates to those which are energetically favorable or most accessible. Different bacteria have different preferences, based on their environments and the neighboring microbes that compete for or ... Read More

Microbial Awards Season in Biology 350!

I like to encourage my students to explore the intersection between art and microbiology. Science + art = awesome! In any event, in this blog post, I describe two microbial art competitions in my microbiology course at the University of Puget Sound. I think my micronauts did some remarkable w... Read More

The Bacteria Song by the Science Pirates

Science Pirates Songs presents the Bacteria Song by New Mexico State University 2003. These animated songs are from the adventure learning game, 'Science Pirates: The Curse of Brownbeard', which guide middle school students through concepts in both science and food safety. Read More

How to be a successful food borne pathogen: step 1, grow on food

Food microbiology is an important issue we cover on this blog, because food safety is vital to prevent foodborne illness. The use of technologies like whole-genome sequencing help identify and pinpoint the source of microbial contaminants, but how do microbes become contaminants in the first pla... Read More

Flaviviruses unexpectedly shut off host translation

It was a peer review request that got Alessia Ruggieri and her group at University of Heidelberg to look more closely at how Dengue virus manipulates the cellular translation and stress machineries during infection.

In a previous study, Ruggieri showed that Hepatitis C virus infection induced... Read More

Outbreak of H7N2 Flu in Cats

Many mBiosphere readers will know that the influenza A virus infects multiple species, and this ability to infect birds, humans, and other mammals such as pigs is one of the ways virions can exchange genetic information, leading to new viruses able to cause major outbreaks. However, few mBiosphe... Read More

10 Things You Need to Know about mSphereDirect

mSphereDirect is an exciting new pathway to publish your research! This groundbreaking new submission path puts you in control of getting your original research reviewed and published as soon as possible. We’ve prepared the most important things to keep in mind while preparing your manuscript s... Read More

Describing a viral quasispecies

Virus populations do not consist of a single member with a defined nucleic acid sequence, but are dynamic distributions of nonidentical but related members called a quasispecies (illustrated at left). While next-generation sequencing methods have the capability of describing a quasispecies, the ... Read More

Microbiomes in far-flung places: characterizing the arctic Inuit gut microbiome

The hamlet of Resolute Bay is a tiny Arctic village in the Nunavut territory of Canada with a population that hovers at or below 300. Over hundreds of perhaps even thousands of years, the traditional Inuit diet in Resolute Bay and elsewhere has been dictated by the Arctic environment. The diet i... Read More
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