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HIV gets the zinc finger

Because all animal viruses initiate infection by binding to a receptor on the cell surface, this step has long been considered a prime target for antiviral therapy. Unfortunately, drugs that block virus attachment to cells have never shown much promise. Another approach, which is to ablate the r... Read More

TWiV 265: This year in virology



Hosts: Vincent Racaniello, Alan Dove Read More

Men More Likely to Commit Research Misconduct than Female Counterparts #mBio #science

It’s not hard to see that men are more likely to engage in risky behaviors than women, or that crime rates are many times higher among men, but this tendency to break the rules also extends to male scientists, according to a study to be published on January 22 in mBio®, the online open-access jo... Read More

How to give a great lecture

There are many elements that go into making a great lecture, but the most important one is to lose the notes. If you are giving lectures in a course at any level, the worst practice you can engage in is to rely on notes. This behavior is problematic for several reasons. You will not properly kno... Read More

El podcast del Microbio Nº 300 and 301. Joseph Lister





























El podcast del Microbio Nº 300 and 301 is dedicated to Joseph Lister, the British surgeon pioneer of antiseptic surgery, o... Read More

TWiV special: MERS-coronavirus in dromedary camels



Host: Vincent Racaniello


Guests: Read More

TWiV 281: The Salk legacy with Peter L. Salk



Host: Vincent Racaniello


Guest: Peter L. Salk


Vincent meets up with Peter L. Salk to talk about development of the fir... Read More

TWiV 293: Virology Down Under

Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.


Hosts:  Read More

Blastocystis Parasite Blog

Our bodies are made up by cells containing our own DNA. Plus 10 times as many with foreign DNA. The bacteria found on our skin, and inside our organs (intestine, vagina, mouth, nose, etc.) are referred to as our “microbiome”, outnumber our own cells by 10 to 1, and make up a vital organ with ind... Read More

Bespoke microbiome therapy to manage plant diseases

In this paper we describe the perspective of following the achievements in medicine, where gut microbiome transplants are proving to be a powerful method to overcome several gastrointestinal disorders and many other physiological problems, to possible solve diseases in plants. There is strong si... Read More

To combat the overuse of antibacterials, stop using the absolutely terrible word, "antibiotic"

There are many reasons why bacteria evolve resistance to antibacterials, but one of the preventable reasons is the over-prescription of antibacterials to patients who don't have bacterial infections. But how to get people to stop asking for antibacterials? My suggestion is to stop using the wor... Read More

El podcast del microbio Nº 366: Bioinformática contra el VIH. (Bioinformatics against HIV)



























El podcast del microbio Nº 366 summarize a recent article published in PNAS on the characterization of the critical step in HIV-1 protease maturation by using bioinformatics tools. El podcast del microb... Read More

Influenza H5N1 x H1N1 reassortants: ignore the headlines, it’s good science

Those of you with an interest in virology, or perhaps simply sensationalism, have probably seen the recent headlines proclaiming another laboratory-made killer influenza virus. From The Independent: ‘Appalling irresponsibility: Senior scientists attack Chinese researchers for creating new strain... Read More

Did hepatitis C virus originate in horses?

About 2% of the world’s population is chronically infected with hepatitis C virus (HCV). This enveloped, positive-strand RNA virus was discovered in 1989, but serological and phylogenetic evidence indicates that it has been infecting humans for hundreds of years, perhaps as long ago as the 14th ... Read More

A WORD on the constraints of influenza virus evolution

Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza vir... Read More

The Science Behind Honey’s Eternal Shelf Life

Modern archeologists, excavating ancient Egyptian tombs, have often found something unexpected amongst the tombs’ artifacts: pots of honey, thousands of years old, and yet still preserved. Through millennia, the archeologists discover, the food remains unspoiled, an unmistakable testament to the... Read More

TWiP 65 letters

 


Perry writes:


Greetings Vincent and Dick,


Hooray for finally mentioning G. pulchrum in episode 62, my most favorite parasite and one worthy of further discussion. As a diagnostic veterinary pathologist, I encounter this spirurid in approximately... Read More

BacterioFiles 174 - Synthetic Cells Sense and Send Signals

This episode: Bacteria with engineered circuits can detect and keep a record of stuff in their environment, like in the gut!


(14.6 MB, 15.9 minutes)


Show notes: 
Read More

El podcast del microbio Nº 259: Gazapos microbiológicos (microbial goofs)



























El podcast del Microbio Nº259 describes some funny microbiological goofs in Spanish newspapers. El podcast del Microbio Nº 259 d... Read More

On a Cellular Level, We Are ALL Overachievers!

In this blog post, I show a science-cartoon by the great "Beatrice the Biologist" that illustrates an important point in my freshman introductory cell and molecular biology course: no matter how tired we might be, we are incredibly busy on a cellular level! Beatrice is a fine artist who underst... Read More

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