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Treating hepatitis C by blocking a cellular microRNA

Miravirsen is a drug that binds to and blocks the function of a cellular microRNA called miR-122 that is required for the replication of hepatitis C virus (HCV). Treatment of chimpanzees chronically infected with HCV with this drug leads to suppression of viral replication. The results of a phas... Read More

De-discovering pathogens: Viral contamination strikes again

Do you remember the retrovirus XMRV, initially implicated as the cause of chronic fatigue syndrome, and later shown to be a murine virus that contaminated human cells grown in mice? Another virus thought to be associated with human disease has recently been shown to be a contaminant, derived fro... Read More

A virus that melts sea stars

Sea stars are lovely marine invertebrates with a round central body connected to multiple radiating legs (photo credit). In the past year millions of sea stars in the west coast waters of North America have melted into piles of slime and ossicles. Sea star associated densovirus might be the caus... Read More

TWiV 337: Steamer

Host: Vincent Racaniello 

Guests: Michael Metzger and  Read More

ASM GM 2014 - ASM ¡en vivo!

ASM2014 tiene "sabor Latino". Por primera vez podrás participar de ASM ¡en vivo! Tendremos una sección solo en Español donde las anfitrionas, Greetchen y Catalina (Mundo de l... Read More

Viruses Could Help Fight Deadly Superbugs.

Viruses that are harmless to humans might help fight the deadly scourge of bacteria that can't be treated with antibiotics, researchers say.

These viruses could be used in hand santizers, and to treat exposed surfaces in hospitals, which are hotbeds of antibiotic resistance, the researchers n... Read More

Retroviruses R us

About eight percent of human DNA is viral – remnants of ancestral infections with retroviruses. These endogenous retroviral sequences do not produce infectious viruses, and most are considered to be junk DNA. But some of them provide important functions. The protein called syncytin, which is ess... Read More

Using Routine Surveillance Data to Estimate the Epidemic Potential of Emerging Zoonoses: Application to the Emergence of US Swine Origin Influenza A H3N2v Virus

A simple new method better assesses the risks posed by emerging zoonotic viruses (those transmissible from animals to humans), according to a study published in PLOS Medicine this week. Dr. Simon Cauchemez and colleagues from Imperial College London in the UK and the Centers for Disease Control ... Read More

Poliovirus silently (and not so silently) spreads

Poliovirus has been found in sewage in Israel. The virus detected is not vaccine-derived poliovirus; it is wild-type 1 poliovirus, the strain that occurs naturally in the wild and which the World Health Organization is trying very hard to eradicate from the planet. Read More

Poliovirus escapes antibodies

Antigenic variation is a hallmark of influenza virus that allows the virus to evade host defenses. Consequently influenza vaccines need to be reformulated frequently to keep up with changing viruses. In contrast, antigenic variation is not a hallmark of poliovirus – the same poliovirus vaccines ... Read More

Heartland virus disease

Six new cases of Heartland virus disease have been identified in residents of Missouri and Tennessee. The cause of this disease appears to be a member of the Phlebovirus genus in the Bunyaviridae family that was first identified in 2009 and appears to be transmitted by the Lone Star tick (Amblyo... Read More

Amyotrophic lateral sclerosis and viruses and my ice bucket challenge

Many people have a new awareness of the disease known as amyotrophic lateral sclerosis, or ALS, thanks to the Ice Bucket Challenge initiated by the ALS Association. Fewer might know that retroviruses have been proposed to play a role in the development of the disease. Read More

Design, engineering and utility of biotic games

First of the three videos related to research article appearing in Lab on a Chip. I. H. Riedel-Kruse et al "Design, Engineering and Utility of Biotic Games". Read the article by clicking "source" above.

From the abstract:

Games are a significant and defining part of human culture, and thei... Read More

ASM GM 2014 - Fossilized Feces Help Anthropologists Understand Pre-Columbian Cultures

By evaluating the bacteria and fungi found in fossilized feces, microbiologists are providing evidence to help support archeologists' hypotheses regarding cultures living in the Caribbean over 1,500 years ago. Researchers discuss how the analysis of 1,500-year-old coprolites from archeologica... Read More

Viral Supercomputer Simulations

Jason Roberts, a virologist at the Victorian Infectious Disease Reference Laboratory in Melbourne, Australia, creates three-dimensional simulations of viruses showing how the molecules that make up the capsid and genome might move in very short periods of time. I visited Jason in his laboratory ... Read More

Infant antibiotic use linked to adult diseases

A new study led by researchers at the University of Minnesota has found a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. The imbalances in gut microbes, called dysbiosis, have been tied to infectious diseases, allergies and other autoimmun... Read More

Programmed Cell Death Activates Latent Herpesviruses

Researchers have found that apoptosis, a natural process of programmed cell death, can reactivate latent herpesviruses in the dying cell. The results of their research, which could have broad clinical significance since many cancer chemotherapies cause apoptosis, was published ahead of print in ... Read More

Twenty-six lectures in virology

In the spring of each year I teach a virology course to undergraduates and masters students at Columbia University. I produce video recordings of all my lectures not only for students in the course, but for anyone else who is interested in learning about viruses.

You can find my virology lect... Read More

C. difficile Vaccine Proves Safe, 100 Percent Effective In Animal Models

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
... Read More

PhatoMap of New York Subway System

The microbes that call the New York City subway system home are mostly harmless, but include samples of disease-causing bacteria that are resistant to drugs — and even DNA fragments associated with anthrax and Bubonic plague — according to a citywide microbiome map published today by Weill Corne... Read More
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