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Programmed Cell Death Activates Latent Herpesviruses

Researchers have found that apoptosis, a natural process of programmed cell death, can reactivate latent herpesviruses in the dying cell. The results of their research, which could have broad clinical significance since many cancer chemotherapies cause apoptosis, was published ahead of print in ... Read More

Proposed US policy on dual use research of concern

The US Office of Science and Technology Policy recently released proposed guidelines for maximizing the benefits and minimizing misuse of life sciences research. The measures establish oversight responsibilities for universities and other institutions that receive Federal funding. Read More

Your viral past

Did you ever wonder what different virus infections you have had in your lifetime? Now you can find out with just a drop of your blood and about $25.

Immune defense systems of many hosts produce antibodies in response to virus infections. These large proteins, which are generally virus specif... Read More

Poliovirus silently (and not so silently) spreads

Poliovirus has been found in sewage in Israel. The virus detected is not vaccine-derived poliovirus; it is wild-type 1 poliovirus, the strain that occurs naturally in the wild and which the World Health Organization is trying very hard to eradicate from the planet. Read More

Interview of Dr. Vincent Racaniello - Journey with Virus

Dr. Vincent Racaniello is the Higgins Professor of Microbiology and Immunology at the college of Physicians and Surgions of Columbia University. Along with his academic research, he is known for expanding knowledge with great contributions through his virology blog virology.ws, and his wide podc... Read More

End of moratorium on influenza H5N1 research

In early 2012 influenza virus researchers around the world decided to stop working on highly pathogenic avian influenza H5N1 virus. This decision came after work from the Fouchier and Kawaoka laboratories revealed the isolation of influenza H5N1 strains that can be passed among ferrets by aeroso... Read More

Poliovirus escapes antibodies

Antigenic variation is a hallmark of influenza virus that allows the virus to evade host defenses. Consequently influenza vaccines need to be reformulated frequently to keep up with changing viruses. In contrast, antigenic variation is not a hallmark of poliovirus – the same poliovirus vaccines ... Read More

Twenty-six lectures in virology

In the spring of each year I teach a virology course to undergraduates and masters students at Columbia University. I produce video recordings of all my lectures not only for students in the course, but for anyone else who is interested in learning about viruses.

You can find my virology lect... Read More

Design, engineering and utility of biotic games

First of the three videos related to research article appearing in Lab on a Chip. I. H. Riedel-Kruse et al "Design, Engineering and Utility of Biotic Games". Read the article by clicking "source" above.

From the abstract:

Games are a significant and defining part of human culture, and thei... Read More

Amyotrophic lateral sclerosis and viruses and my ice bucket challenge

Many people have a new awareness of the disease known as amyotrophic lateral sclerosis, or ALS, thanks to the Ice Bucket Challenge initiated by the ALS Association. Fewer might know that retroviruses have been proposed to play a role in the development of the disease. Read More

Under the Microscope and the new science blog network by PopSci

Popular Science has just launched a new science blogging network with 13 blogs. Among them are two that have a focus on microbiology, Under the Microscope by JA Tetro and Our Modern Plague by Brooke Borel. Each blog has an inaugural post that outlines the author's vision for future subject matte... Read More

A few reminiscences on Hilary Koprowski

Virologist Hilary Koprowski died on 11 April 2013 at the age of 96. His main accomplishments are nicely summarized in the New York Times, but for a more comprehensive overview of his life, I highly recommend his biography Listen to the Music by Roger Vaughan. I did not have many opportunities to... Read More

C. difficile Vaccine Proves Safe, 100 Percent Effective In Animal Models

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
... Read More

Unusual mortality pattern of 1918 influenza A virus

The 1918 influenza pandemic was particularly lethal, not only for the very young and the very old (as observed for typical influenza), but unexpectedly also for young adults, 20 to 40 years of age (pictured). It has been suggested that the increased lethality in young adults occurred because the... Read More

TWiV 347: Rose rosette and squirrel roulette

Hosts: Vincent RacanielloAlan Dove, and Rich Condit


Vincent, Alan, and Rich discu... Read More

Ebola virus enters the United States

Given the extent of the Ebola virus outbreak in West Africa, transport of an infected individual to the US was bound to happen. The case is an adult who had contact with an Ebola virus-infected woman in Liberia, then traveled to Dallas. He had no symptoms before arriving in the US and therefore ... Read More

BacterioFiles 217 - Fungus Fortifies Fly Food

This episode: Fruit flies have microbes that help them get more nutrition out of low-quality food!


(8.4 MB, 9.1 minutes)


Show notes: 
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Infant antibiotic use linked to adult diseases

A new study led by researchers at the University of Minnesota has found a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. The imbalances in gut microbes, called dysbiosis, have been tied to infectious diseases, allergies and other autoimmun... Read More

Virology question of the week: why a segmented viral genome?

This week’s virology question comes from Eric, who writes:

I’m working on an MPH and in one of my classes we are currently studying the influenza virus. I’d forgotten that the genome is in 8 separate parts. Curious, I’ve been searching but can’t find any information as to why that is?

What... Read More

Hepatitis A virus infections associated with berry and pomegranate mix

An outbreak of hepatitis A virus (HAV) infections in eight US states has been attributed to consumption of Townsend Farms Organic Anti-Oxidant Blend frozen berry and pomegranate mix purchased from Costco markets. Since March 2013, 118 individuals have acquired the infection and 80% report having... Read More
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