Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza vir... Read More
In four months, 155 countries will together switch from using trivalent to bivalent oral poliovirus vaccine. Will this change lead to more cases of poliomyelitis? Read More
Throat swab of (5) years old child from emergency department for culture and sensitivity clinical summary scarlet fever.
Streptococcus pyogenes, or Group A Streptococcus, is a spherical, Gram-positive bacterium. S. pyogenes displays streptococcal group A antigen on its cell wall and typic... Read More
Hepatitis B virus (HBV, illustrated) is a substantial human pathogen. WHO estimates that there are now 240,000,000 individuals chronically infected with HBV worldwide, of which 25% will die from chronic liver disease or hepatocellular carcinoma. The hepatitis B virus vaccine is highly effective ... Read More
Until recently cancers were seen as lifestyle and genetic diseases, brought on by exposure to carcinogens or a mutated gene. Recent studies are linking microbes to many diffe... Read More
Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More
This is a paper from the Geomicrobiology lab at the Jackson School of Geosciences at the University of Texas at Austin. It was recently published in a special issue of Geomicrobiology Journal focused on geomicrobiology of subsurface microorganisms in cave environments.
In this study we attemp... Read More
Russian President Vladimir Putin claimed Wednesday his country had developed a vaccine for the Ebola virus which has killed thousands of people in west Africa.
But Putin, who is famed for his talent for headline-grabbing announcements, did not give any name for the vaccine, nor did he say how... Read More
A form of bacteria responsible for respiratory illness, including the deadly pneumonia known as Legionnaire's disease, may be able to grow in windshield washer fluid and was isolated from nearly 75% of school buses tested in one district in Arizona. The participant will discuss findings from ... Read More
Viruses inspire many different types of art, but I was unaware of the number of people who make viruses out of fiber! Keep reading for some photographs of what I have found. Read More
Exposure to reactive oxygen species, exposure to ionizing radiation, exposure to UV light – all of these are dangerous because of their potential to alter DNA sequences. Changes in DNA can affect a protein coding sequence, potentially influencing its function, but changes in regulatory regions c... Read More
BOULDER - Key factors that can combine to produce a Zika virus outbreak are expected to be present in a number of U.S. cities during peak summer months, new research shows. Read More
Remember Ebolaviruses? Many people are still working on vaccines and therapeutics. Here is a very nice story on a promising antiviral compound that is very effective at preventing disease in monkeys. But it doesn't work in mice - it's degraded. You know what they say - mice lie, monkeys exaggera... Read More
It has been speculated that the development of neurological disease and fetal abnormalities after Zika virus infection may be due to the presence of antibodies against other flaviruses that enhance disease. In support of this hypothesis, it has been shown that antibodies to dengue virus enhance... Read More
Daniel and Vincent solve the case of the Truck Driver from India, discuss why parasites resistant to an antimalarial drug are not transmitted by mosquitoes, and introduce Paul who presents a new case study.
Hosts: Read More
Pneumonia remains a serious worldwide problem, especially among the young, elderly, and immunocompromised. Over 900,000 children die each year due to the disease, and respiratory syncytial virus (RSV) is the most common viral cause (Streptococcus pneumoniae and Haemophilus influenzae type b bein... Read More
The study researchers found that placing a small, detoxified amount of E. coli in the guts of mice led to an increase in levels of leptin - known as the "satiety hormone."
Within 7 days of the increase, the number of sweet taste receptors on the rodents' tongues reduced, diminishing their ap... Read More
The late computer scientist Randy Pausch wrote many inspirational things about life and academia during his struggle with pancreatic cancer. As we approach 2015, his words are helpful to me, and perhaps to others. About life, about academia, about helping others...and making our dreams come tr... Read More
A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode.
Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts.
Host... Read More