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BacterioFiles 180 - Phage Functions Fight Fortifications

This episode: Some phages can fight back against bacterial defenses with recently discovered genes!


(8.3 MB, 9 minutes)


Show notes: 
Journal Paper Read More

TWiM #87: Avogadro, archaeal fossils, and ICAAC

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

Poliovirus on Time

Poliovirus has made the cover of Time magazine. The Time cover image for the 14 January 2013 issue is a model of poliovirus bound to a soluble form of its cellular receptor, CD155. I was part of the team that solved the structure of this complex in 2000, together with the laboratories of Jim Hog... Read More

WHO will switch to type 2 inactivated poliovirus vaccine

The World Health Organization’s campaign to eradicate poliomyelitis made impressive inroads in 2012: only 212 cases were reported, compared with 620 the previous year; moreover, India remained polio-free. The dark side of this story is that as wild polio is eliminated, vaccine-associated poliomy... Read More

Viruses on Time

Poliovirus recently made the cover of Time magazine. Prompted by a reader question, I searched the Time archive to find out if there have been other virology-themed covers. I found fifteen in all, depicting poliovirus (3), herpesvirus (1), HIV/AIDS (4), influenza (5), and SARS coronavirus (2) (I... Read More

Antibiotics work against viruses

Got your attention, eh? This page discusses why so many people believe that antibiotics kill viruses, and what you can do about that myth. Actually, it's not even a myth ... antibiotics DO work against viruses. The problem is that the word "antibiotics" is redefined by some to be a synonym of... Read More

How to give a great lecture

There are many elements that go into making a great lecture, but the most important one is to lose the notes. If you are giving lectures in a course at any level, the worst practice you can engage in is to rely on notes. This behavior is problematic for several reasons. You will not properly kno... Read More

Evidence-based antibiotic usage

New recommendation encourages physicians to prescribe _antibacterials_ instead of antibiotics for bacterial infections. This recommendation is based on compelling evidence that the word "antibiotic" confuses almost everyone, including some doctors. The confusion leads to strong patient demands... Read More

Men More Likely to Commit Research Misconduct than Female Counterparts #mBio #science

It’s not hard to see that men are more likely to engage in risky behaviors than women, or that crime rates are many times higher among men, but this tendency to break the rules also extends to male scientists, according to a study to be published on January 22 in mBio®, the online open-access jo... Read More

A WORD on the constraints of influenza virus evolution

Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza vir... Read More

TWiP 77: Mixed messages

Vincent and Dickson discuss the exchange of messenger RNAs between a parasitic plant and its hosts.


Hosts: Vincent Racaniello and Dickson Despommier Read More

Harvard University: Great virology, bad science writing

Harvard University is home to some of the world’s finest virologists. But apparently they do not communicate with the writers at Harvard Magazine, where a botched story on the avian H5N1 influenza virus has just been published. Read More

BacterioFiles Micro Edition 147 - Clostridium Conquers Colleagues

This episode: Non-pathogenic Clostridium difficile strains can protect hamsters against their disease-causing bacterial siblings!


(7 MB, 7.5 minutes)


When hamsters were colonized with toxin-free strains of C. difficile, they were better able to resist infection b... Read More

The Science Behind Honey’s Eternal Shelf Life

Modern archeologists, excavating ancient Egyptian tombs, have often found something unexpected amongst the tombs’ artifacts: pots of honey, thousands of years old, and yet still preserved. Through millennia, the archeologists discover, the food remains unspoiled, an unmistakable testament to the... Read More

To combat the overuse of antibacterials, stop using the absolutely terrible word, "antibiotic"

There are many reasons why bacteria evolve resistance to antibacterials, but one of the preventable reasons is the over-prescription of antibacterials to patients who don't have bacterial infections. But how to get people to stop asking for antibacterials? My suggestion is to stop using the wor... Read More

Friday flu shot

Yesterday many US newspapers carried front-page stories on the severity of influenza so far this season. The New York Times story began with “It is not your imagination — more people you know are sick this winter, even people who have had flu shots.” Is this really a bad flu season? Read More

El podcast del Microbio Nº 300 and 301. Joseph Lister





























El podcast del Microbio Nº 300 and 301 is dedicated to Joseph Lister, the British surgeon pioneer of antiseptic surgery, o... Read More

TWiV 282: Tamiflu and tenure too

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Hosts:  Read More

A video explanation of Ebola Virus.

A video explanation of Ebola Virus. Drawn and narrated by Armando Hasudungan. Read More

Did hepatitis C virus originate in horses?

About 2% of the world’s population is chronically infected with hepatitis C virus (HCV). This enveloped, positive-strand RNA virus was discovered in 1989, but serological and phylogenetic evidence indicates that it has been infecting humans for hundreds of years, perhaps as long ago as the 14th ... Read More

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