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Shiga toxin: no preassembly required

The molecular order of events is important in virulence, and a new paper published in the Journal of Bacteriology looks at the order of events necessary for bacterial toxin delivery to a host cell. Specifically, the authors looked at the assembly of Shiga toxin, produced by Shigella dysenteriae ... Read More

Cyclic-di-GMP takes center stage

How does a single-celled organism ‘know’ how to respond to its environmental conditions? Understanding microbial cell signaling is one way to determine how bacteria will react in a particular setting. In the past decade, researchers have revealed a significant role for cyclic-di-GMP in bacterial... Read More

Colors of Superbug !

Methicillin Resistant Staphylococcus aureus (MRSA) isolated from animals. The organism was grown on seven different agar medium. On blood agar (Centre), it forms small to medium sized colonies surrounded by weak beta-hemolysis. It shows diverse types of color in different chromogenic medium- pin... Read More

THE RIDDLE OF THE R.I.D.L _ Zika virus Comics (Playlist)

In Zanzare, the new comic from Cimaza (www.cimazacomics.com/), we are plunged head-first into the global mystery of the Zika virus. We meet the mosquitoes (in Italian: zanzare) implicated in its spread; but the insects plead their innocence, saying it's all a misunderstanding. They lay their cas... Read More

MMP #2: Ultrasmall bacteria with Birgit Luef and Chris Brown

Host: Jeff Fox Read More

Interview with Dr. Amy Apprill

Amy Apprill is a researcher of Marine Microbiology. Her work focuses on the relation of Bacteria and Archaea to the health and ecology of marine animals. Her interest is on how animal associated microbes reflect the alterations in the surrounding marine environment that may be related to climate... Read More

TWiV 397: Trial by error

Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.


Host: Vincent Racaniello 


Gue... Read More

Researchers hope hybrid compounds can sensitize and inhibit malaria parasites in one blow

Because of its safety, efficacy, and affordability, chloroquine remains the treatment of choice for all Plasmodium species, except in regions with chloroquine-resistant P. falciparum. Chloroquine-resistant protists are treated with combination therapy, which includes artemisinin-derived molecule... Read More

BacterioFiles 263 - Germ Jettisoned Jellyfish Genes

This episode: Microscopic parasites of fish and worms actually came from jellyfish-like animals, after losing most of their genome!


(7.7 MB, 8.3 minutes)


Show notes: 
Read More

TWiV 395: The cancer thief

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. 


Hosts:  Read More

Zika virus

The rapid spread of Zika virus through the Americas, together with the association of infection with microcephaly and Guillain-Barré syndrome, have propelled this previously ignored virus into the limelight. What is this virus and where did it come from?
Read More

India has been free of polio for three years

Three years ago today, on 13 January 2011, the last case of poliomyelitis was reported in India. This achievement represents a remarkable turnaround for a country where control of the disease had for years been extremely difficult. As recently as 2009 there were 741 confirmed cases of polio caus... Read More

MMP #14: A look at several microorganisms involved with electricity.

Host: Jeff Fox with special guests, Gemma Reguera and Geoffrey Gadd.


Gemma Reguera of Michigan State University in East Lansing and Geoffrey Gadd of the University of Dundee in Scotland talk with Jeff Fox about their efforts, to probe some of the electrical properties of materials pro... Read More

TWiM 101 Letters

Eric writes:


Dear TWIMers,


I am a retired computer programmer and also a free market libertarian. I listened to a recent podcast where the subject of mandatory hand washing by food workers was tossed around. I would like to present a few more of the free marke... Read More

New promise for treatment of enterovirus infection

Feeling a bit under the weather? There’s a decent chance you’re suffering from an infection with an enterovirus. Enteroviruses are a commonly encountered virus, especially in the summer and fall. They can cause a variety of symptoms, from cold-like symptoms such as runny nose or fever to more se... Read More

Antibodies to dengue virus enhance infection by Zika virus

It has been speculated that the development of neurological disease and fetal abnormalities after Zika virus infection may be due to the presence of antibodies against other flaviruses that enhance disease. In support of this hypothesis, it has been shown that antibodies to dengue virus enhance... Read More

Fighting viruses - amazing new 21st century lab

Looking out of the window isn’t something most office workers would consider a luxury. But then, most people don’t work in a maximum security, biosafety level 4 high-containment research facility, working to protect the UK’s multi-billion pound agricultural industry from dangerous and highly inf... Read More

Virus Watch: Zika Edition

Virus Watch is a new weekly video series that explores the amazing world of viruses. This week: the latest research on Zika virus, including finding virus in Brazilian monkeys, dengue antibodies helping Zika virus infection, and brain organoids to study how Zika virus causes microcephaly. Read More

Toward development of microarrays to test water safety

Imagine taking an ocean-side vacation, with the sun, sand, and water lulling you to relaxed bliss. After day at the beach, you experience an intense bout of stomach cramps and – more delicately put – GI distress. A rare day off is ruined because of a bug you picked up. Next, imagine a situation ... Read More

Getting closer to understanding Zika virus, one genome at a time

Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More
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