Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.
This episode: Engineered bacteria can be made to produce many different useful kinds of biofilm!
(10.5 MB, 11.5 minutes)
A new virus called Pithovirus sibericum has been isolated from 30,000 year old Siberian permafrost. It is the oldest DNA virus of eukaryotes ever isolated, showing that viruses can retain infectivity in nature for very long periods of time. Read More
Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More
A recent study by scientists at the Ludwig Center for Cancer Immunotherapy offers a new, multifaceted therapy for destroying tumors. A team of researchers led by Dmitriy Zamarin combined checkpoint blockade, a technique aimed at enhancing antitumor immune responses, with oncolytic viral therapy,... Read More
In this blog post, I describe how I use the commonly available pGLO plasmid to teach freshman students basic concepts about transformation, receptor recognition, drug resistance mechanisms, and gene regulation. Oh, and fluorescence via GFP! Read More
Segmented genomes abound in the RNA virus world. They are found in virus particles from different families, and can be double stranded (Reoviridae) or single stranded of (+) (Closteroviridae) or (-) (Orthomyxoviridae) polarity. Our recent discussion of the advantages of a segmented viral genome,... Read More
In this blog post, I describe some "rules for academics" as well as my own "rules for research." I hope that readers find them useful and perhaps a bit humorous. Read More
Wild poliovirus has been detected in the sewers of Brazil and Israel. Fortunately, no cases of poliomyelitis have been reported in either country. Why is poliovirus present in these countries and what are the implications for the eradication effort?
Wild type poliovirus (e.g. not vaccine-deri... Read More
You don’t want to miss asm2014. We’ve compiled a list of five things not to miss at the 114th American Society for Microbiology General Session.
Click the "source" link or copy/paste this URL into your browser: http://blog.puritanmedproducts.com/bid/383376/asm2014-Five-Things-Not-to-Miss-at-... Read More
The journal "RNA Biology" just published a memorial issue dedicated to the late, great Carl Woese. The entire issue is open access. I have a small contribution, but the entire issue is filled with great science, wonderful memories, and a fine celebration of a scientist who changed the way we l... Read More
In this post from my blog, I discuss the recent interest in snarky-funny academic hashtags on Twitter, such as #overlyhonestsyllabi. Just like students, educators need to blow off some steam (especially as classes approach!). But it is also important to remember our educational goals, and matc... Read More
Middle Eastern respiratory syndrome coronavirus (MERS-CoV), first identified in the fall of 2012 in a Saudi Arabian patient, has since infected over 160 individuals, causing 71 deaths. Identifying the source of infection is important for efforts to prevent further infections. Recently two studie... Read More
Recently, the American Academy of Microbiology released a new report, Viruses Throughout Life & Time: Friends, Foes, Change Agents that delves into the origin of viruses, the overlooked biological and microbial ecological role of viruses, and how these live forms have contributed to evolution. T... Read More
Until recently cancers were seen as lifestyle and genetic diseases, brought on by exposure to carcinogens or a mutated gene. Recent studies are linking microbes to many diffe... Read More
This episode: Defective phages in bacterial genomes can still have burdensome effects! Why do the bacteria keep them around?
(10.4 MB, 11.3 minutes)
In this blog entry, I describe how working with the artist Katie McKissick ("Beatrice the Biologist") helped improve my freshman biology course. The intersection of biology and art benefits both! Read More
Wine grapes present a unique biogeography model, wherein microbial biodiversity patterns across viticultural zones not only answer questions of dispersal and community maintenance, they are also an inherent component of the quality, consumer acceptance, and economic appreciation of a culturally ... Read More
PLOS ONE authors Cybulski, Clements and Prakash describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume f... Read More
Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecules can be involved, and labeling with small molecules, such as fluorescent dyes, biotin, and other groups can be readily achieved.
Click chemistry reaction takes pl... Read More