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Attenuated influenza vaccine enhances bacterial colonization of mice

Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More

BacterioFiles Micro Edition 163 - Pseudomyrmex Sidekicks Stop Sprout Sickness

This episode: Ants teaming with bacteria help defend plants from bacterial pathogens!


(9.4 MB, 10.2 minutes)


Show notes: 
News item/ Read More

Neoscytalidium dimidiatum arthrospore


It is a well recognized uncommon cause of skin and nail infection of the hands and feet . Unlike Dermatophytosis these mould infections are not contagious. There are few reports of invasive infection caused by N. dimidiatum; most infections occurred in immunocompromised hosts. Arthrospores ar... Read More

Twenty-six lectures in virology

In the spring of each year I teach a virology course to undergraduates and masters students at Columbia University. I produce video recordings of all my lectures not only for students in the course, but for anyone else who is interested in learning about viruses.

You can find my virology lect... Read More

Pithovirus: Bigger than Pandoravirus with a smaller genome

A new virus called Pithovirus sibericum has been isolated from 30,000 year old Siberian permafrost. It is the oldest DNA virus of eukaryotes ever isolated, showing that viruses can retain infectivity in nature for very long periods of time. Read More

Remembering a Microbial Hero™: The Late, Great Abigail Salyers.

Here I remember a person who a great deal of influence on my views about microbiology in the classroom, and the laboratory: the late Abigail Salyers. RIP, Abigail. Read More

MERS-CoV genome found in dromedary camels

Middle Eastern respiratory syndrome coronavirus (MERS-CoV), first identified in the fall of 2012 in a Saudi Arabian patient, has since infected over 160 individuals, causing 71 deaths. Identifying the source of infection is important for efforts to prevent further infections. Recently two studie... Read More

Heartland virus disease

Six new cases of Heartland virus disease have been identified in residents of Missouri and Tennessee. The cause of this disease appears to be a member of the Phlebovirus genus in the Bunyaviridae family that was first identified in 2009 and appears to be transmitted by the Lone Star tick (Amblyo... Read More

BacterioFiles Micro Edition 155 - Cells Save Superannuated Sequences

This episode: Bacteria are able to incorporate DNA from the environment into their genomes, even if it's thousands of years old!


(9.6 MB, 10.5 minutes)


Show notes: 
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Influenza A viruses in bats

It is well known that aquatic birds are a major reservoir of influenza A viruses, and that pandemic human influenza virus strains of the past century derive viral genes from this pool. The recent discovery of two new influenza A viruses in bats suggests that this species may constitute another r... Read More

Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate

Wine grapes present a unique biogeography model, wherein microbial biodiversity patterns across viticultural zones not only answer questions of dispersal and community maintenance, they are also an inherent component of the quality, consumer acceptance, and economic appreciation of a culturally ... Read More

Click-Chemistry Labeling of Oligonucleotides and DNA - Lumiprobe - Protocol


Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecules can be involved, and labeling with small molecules, such as fluorescent dyes, biotin, and other groups can be readily achieved.

Click chemistry reaction takes pl... Read More

Changing influenza virus neuraminidase into a receptor binding protein

The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of the influenza virus particle serve distinct functions during infection. The HA binds sialic acid-containing cellular receptors and mediates fusion of the viral and cell membranes, while the NA removes sialic acids from glycoproteins.... Read More

Dual virus-receptor duel

Viruses are obligate intracellular parasites: they must enter a cell to reproduce. To gain access to the cell interior, a virus must first bind to one or more specific receptor molecules on the cell surface. Cell receptors for viruses do not exist only to serve viruses: they also have cellular f... Read More

A Whiff of Taxonomy – Archaeoglobus fulgidus

Pick an archaeon, any archaeon, and you will find it has a story to tell. Not all archaea are exotic but plenty of them are. These stalwarts live in environments we humans call extreme, where they carry out what to us seem extreme types of metabolic conversions. Most have come rather late into o... Read More

How a microscopic team alters the course of carbon in the Atlantic ocean - Finalist in Ocean 180 Video Challenge

The Amazon river is the largest river in the world. It drains the entire Amazon rainforest, sending leftover nutrients, detritus, and minerals from the South American jungle out into the tropical Atlantic ocean. This runoff forms a freshwater plume, hundreds of miles across, that profoundly affe... Read More

World Polio Day

As a virologist who has worked on poliovirus since 1979, I would be remiss if I did not note that today, 24 October, is World Polio Day. World Polio Day was established by Rotary International over a decade ago to commemorate the birth of Jonas Salk, who led the first team to develop a vaccine a... Read More

Virology question of the week

On the science show This Week in Virology we receive many questions and comments, which are read every week. I also get many questions here on virology blog, which I tend to answer by email. However I think that everyone could benefit from these questions, so I’ve decided to post one here each w... Read More

TWiV 281: The Salk legacy with Peter L. Salk



Host: Vincent Racaniello


Guest: Peter L. Salk


Vincent meets up with Peter L. Salk to talk about development of the fir... Read More

Innocence by Viral Tagging - Finalist in Ocean 180 Video Challenge

Viruses are the most abundant biological entities on the planet with approximately 1030 in the world’s oceans at any time. As such, they play a central role in global nutrient cycling. Despite their ecological importance, little is known about how viruses interact with their hosts due to the dif... Read More

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