A new study led by researchers at the University of Minnesota has found a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. The imbalances in gut microbes, called dysbiosis, have been tied to infectious diseases, allergies and other autoimmun... Read More
The discovery of antibiotics (also referred to as antimicrobials) is perhaps the most revolutionary outcome in the medical sciences during the twentieth century, and has allowed medical practitioners to treat a wide range of bacterial infections; and therefore, antimicrobials are the most common... Read More
This episode: Mice in less sanitary conditions have more diverse gut communities and perhaps less allergy!
(8.15 MB, 8.8 minutes)
THIS IS VIBRIO CHOLERAE O1 OGAWA ISOLATED FROM HUMAN STOOL SWAB PLATED ON BILE SALT AGAR Read More
The microbes that call the New York City subway system home are mostly harmless, but include samples of disease-causing bacteria that are resistant to drugs — and even DNA fragments associated with anthrax and Bubonic plague — according to a citywide microbiome map published today by Weill Corne... Read More
After the governors of New York and New Jersey decided that health workers who have returned from the Ebola virus outbreak in West Africa should be subject to a 21-day quarantine, two Nobel laureates entered the fray. Bruce Beutler feels that the quarantine is the right thing to do, while Peter ... Read More
Here is my annual blogpost using #MicrobialSupremacy to wish all readers a very, very happy holiday season. I do this GFP and prodiosin, as well as luciferase! Enjoy a tiny bit of microbial art, relevant to the season? Read More
Referenced dataset of host/pathogen interactions for Borrelia burgdorferi: linked to Kegg pathway interactome analysis Read More
Last Fall, the great Dr. Margaret McFall-Ngai "virtually visited" my freshman writing class at the University of Puget Sound to discuss symbiosis and Microbial Supremacy with my new students. I had my students read some papers by Dr. McFall-Ngai (including the wonderful "Animals in a Microbial ... Read More
Chronic wasting disease is a prion disease of cervids (deer, elk, moose) that is potentially a threat to human health. A role for environmental prion contamination in transmission is supported by the finding that plants can take up prions from the soil and transmit them to animals. Read More
Virus populations do not consist of a single member with a defined nucleic acid sequence, but are dynamic distributions of nonidentical but related members called a quasispecies (illustrated at left). While next-generation sequencing methods have the capability of describing a quasispecies, the ... Read More
A major goal of viral oncotherapy – the use of viruses to destroy tumors – is to design viruses that kill tumor cells but not normal cells. Two adenoviruses provide perfect examples of how this specificity can be achieved.
Adenovirus CG0070, designed to treat bladder cancer, and adenovirus O... Read More
Throat swab of (5) years old child from emergency department for culture and sensitivity clinical summary scarlet fever.
Streptococcus pyogenes, or Group A Streptococcus, is a spherical, Gram-positive bacterium. S. pyogenes displays streptococcal group A antigen on its cell wall and typic... Read More
Viruses can be broadly classified according to whether or not the particle is enveloped – surrounded by a membrane taken from the host cell – or naked. Some naked viruses apparently are more modest than we believed. Read More
Rhinovirus is the most frequent cause of the common cold, and the virus itself is quite common: there are over 160 types, classified into 3 species. The cell receptor has just been identified for the rhinovirus C species, which can cause more severe illness than members of the A or B species: it... Read More
This study investigates how the overexpression of a specific ORF affects the virulence of E. faecalis. Read More
A new study delineates a sequential pattern of changes in the intestinal microbial population of patients recovering from cholera in Bangladesh, findings that may point to ways of speeding recovery from the dangerous diarrheal disease. The report also finds what appear to be consistent differenc... Read More
The entry of enveloped viruses into cells begins when the membrane that surrounds these virus particles fuse with a cell membrane. The process of virus-cell fusion must be tightly regulated, to make sure it happens in the right cells. The fusion activity of measles viruses isolated from the brai... Read More
Satellites are subviral agents that differ from viroids because they depend on the presence of a helper virus for their propagation. Satellite viruses are particles that contain nucleic acid genomes encoding a structural protein that encapsidates the satellite genome. Satellite RNAs do not encod... Read More