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Hepatitis B viruses in bats

Hepatitis B virus (HBV, illustrated) is a substantial human pathogen. WHO estimates that there are now 240,000,000 individuals chronically infected with HBV worldwide, of which 25% will die from chronic liver disease or hepatocellular carcinoma. The hepatitis B virus vaccine is highly effective ... Read More

TWiM 80 Letters

Bob writes:


Dear TWIM hosts,


I enjoyed episode 76, "Genetic biopixels and a pathogenic sweet tooth". I really enjoyed hearing about the course that Dr. Schaechter teaches and in particular the work his students did in developing the biosensor. I would like to ... Read More

The Walking Dead offers teachable moment about antivirals vs antibacterials

If you teach students about viruses and bacteria, recent episodes of The Walking Dead have been using the term "antibiotic" to stand for antivirals. Since students are probably watching the show, it might be a good time to highlight the mistake. I summarized the issues at the associated URL (ht... Read More

TWiV 296: The real Batman, Linfa Wang

Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.


Hosts: Vincent Racaniello


Guest:  Read More

"Microbe-Powered Jobs: How Microbiologists Can Help Build the Bioeconomy" Infographic

The American Academy of Microbiology has just released a new report, "Microbe-Powered Jobs: How Microbiologists Can Help Build the Bioeconomy," and along with it, an infographic, that summarizes the main points of the report. The full report can be found here: http://bit.ly/1lk346I, and a link t... Read More

TWiV 290: Baylor goes viral

Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.


 


Host: Vincent Racaniello


Guests... Read More

TWiV 288: ebircsnart esreveR

The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.


Hosts: Vincent Racaniello Read More

TWiV 270: Homeland virology

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Hosts: Vincent Racaniello and Rich Condit Read More

Why do viruses cause disease?

Virulence, the capacity to cause disease, varies markedly among viruses. Some viruses cause lethal disease while others do not. For example, nearly all humans infected with rabies virus develop a disease of the central nervous system which ultimately leads to death. In contrast, most humans are ... Read More

Cyanine dyes - Non-sulfonated and Sulfonated cyanines Lumiprobe explains

Sulfonated and non-sulfonated cyanines exhibit very similar fluorescent properties. Non-sulfonated cyanines must be dissolved in organic co-solvent (DMF or DMSO) prior to use, and added to a solution of target molecule in aqueous buffers. Recommended volume of co-solvent should be 10% for Cy3, C... Read More

TWiV 283: No Reston for the weary



 Hosts: Vincent RacanielloAlan Dove Read More

Reducing antibiotic requests from patients with viral infections

For anyone interested in Antibiotic Awareness Week, a big part of the story is that patients (or their parents) demand antibacterials even for viral infections. And doctors often comply, just to get rid of them (the patients, that is). This high-resolution PDF can be printed out for waiting ro... Read More

Viral fiber art

Viruses inspire many different types of art, but I was unaware of the number of people who make viruses out of fiber! Keep reading for some photographs of what I have found. Read More

A saga of HeLa cells

We have been using HeLa cells in my laboratory since 1982, when I arrived at Columbia University Medical Center fresh from postdoctoral work with David Baltimore at MIT. I brought with me a line of HeLa cells and used them for 30 years for our research on viruses. Here is a story of how we lost ... Read More

Polio-like paralysis in California

Recently a number of children in California have developed a poliomyelitis-like paralysis. The cause of this paralysis is not yet known, and information about the outbreak is scarce. However, acute-flaccid paralysis is not uncommon (California would be expected to report about 75 cases a year, b... Read More

Incidence of asymptomatic human influenza A(H5N1) virus infection

When virologists Fouchier and Kawaoka were isolating avian influenza H5N1 viruses that could transmit among ferrets by aerosol, there was consternation from some quarters that such viruses might escape from the laboratory and cause a pandemic in humans. Part of the fear came from the fact that t... Read More

Interview of Cave Microbiologist, Dr. Naowarat Cheeptham (aka Ann)

Dr. Naowarat Cheeptham, is a famous cave microbiologist. Dr. Cheeptham has been fascinated with the world of biology since she was out catching butterflies as a child with her father in her native country, Thailand. Her interest in microbiology developed while studying at Chiang Mai University ... Read More

Retroviruses R us

About eight percent of human DNA is viral ā€“ remnants of ancestral infections with retroviruses. These endogenous retroviral sequences do not produce infectious viruses, and most are considered to be junk DNA. But some of them provide important functions. The protein called syncytin, which is ess... Read More

Top chefs, artisanal food producers, and microbiologists join forces to explore new tastes and textures

Chefs from top-notch restaurants are reaching out to microbiologists, seeking advice that goes beyond traditional food safety or conventional food-processing concerns. With or without professional scientific advice, some chefs and food producers are doing their own microbiological experiments, s... Read More

The neuraminidase of influenza virus

The influenza virus particle is made up of the viral RNA genome wrapped in a lipid membrane (illustrated). The membrane, or envelope, contains three different kinds of viral proteins. The hemagglutinin molecule (HA, blue) attaches to cell receptors and initiates the process of virus entry into c... Read More

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