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Bat SARS-like coronavirus: It’s not SARS 2.0!

A study on the potential of SARS-virus-like bat coronaviruses to cause human disease has reawakened the debate on the risks and benefits of engineering viruses. Let’s go over the science and then see if any of the criticisms have merit. Read More

MdlM117: Chagas, una infección olvidada...., por los países industrializados con Michael Levy

Hoy tenemos la suerte de contar con la compañía de Michael Z. Levy, Catedrático Asistente de Epidemiología en el Departamento de Bioestadística y Epidemiología de la Universidad de Pennsylvania, EE.UU.

Michael ha sido un incansable trabajador en el area de control/eliminación del vect... Read More

BacterioFiles 263 - Germ Jettisoned Jellyfish Genes

This episode: Microscopic parasites of fish and worms actually came from jellyfish-like animals, after losing most of their genome!

(7.7 MB, 8.3 minutes)

Show notes: 
Read More

Viral variation in single cells

It is well known that virus populations display phenomenal diversity. Virus populations are dynamic distributions of nonidentical but related members called a quasispecies. This diversity is restricted in single cells, but is restored within two infectious cycles. Read More

TWiV 396: Influenza viruses with Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

Host: Vincent Racaniello 

Guest:&nbs... Read More

Is brushing your teeth harming your gut microbiome?

In the 1960’s, the microbicide triclosan, was introduced in the United States, and soon after, human weight started to increase dramatically. For some time, researchers have wondered whether triclosan could have played a role in disrupting endocrine dysfunction and contributing to the obesity ep... Read More

TWiV 389: Alphabet hepatitis with Stan Lemon

Host: Vincent Racaniello 

Guest: Stan Lemon

Vinc... Read More

MMP #11: Reexamining the emergence of land plants based on an analysis of the cell walls of charophycean green algae.

Host: Jeff Fox with special guests, Øjvind Moestrup, Peter Ulvskov, and Jesper Harholt.

Øjvind Moestrup and Peter Ulvskov, both at the University of Copenhagen and Jesper Harholt at Carlsberg Laboratory, also in Copenhagen, Denmark, talk with Jeff Fox about their hypothesis about terr... Read More

BacterioFiles 266 - Solar Cyborg Cells Capture Carbon

This episode: Adding exotic elements to convert spore-forming bacteria into light-capturing cyborgs that convert carbon dioxide into useful chemicals!

(9.7 MB, 10.5 minutes)

Show notes: 
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Burkholderia multivorans evolves in bursts in the lungs of cystic fibrosis patients

Leonilde M. Moreira, PhD, has been studying the Burkholderia complex for 15 years. The bacteria, known for causing pneumonia or septicemia in some individuals, can survive for prolonged periods in moist environments. During the last 10 years, it has become one of the more predominant bacteria se... Read More

TWiV 398: Permission to be intuitive

Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation, cleavage and packaging of viral DNA genomes.

Host: Vincent Racaniello 

Guest: ... Read More

Vibrio cholerae population structure changes in a matter of weeks

Although the Gram-negative bacterium Vibrio cholerae (right) is normally associated with human pathogenic disease, most V. cholerae cells spend their lives in an aquatic environment, and only a few of the many serotypes are able to cause disease. When strains acquire the right genetic makeup – s... Read More

BacterioFiles 264 - Small Cells Stimulate Satiety

This episode: Proteins from gut bacteria seems to affect hunger and satiety in their (rodent) hosts!

(7.7 MB, 8.3 minutes)

Show notes: 
Ne... Read More

Whole-genome sequencing can help ID foodborne outbreaks

As we’ve seen in numerous cases in 2015, food contamination is a real issue for a number of different food types. Vegetable, meat, packaged, fresh – even pet food – we’ve seen too many examples of how bacteria can outsmart our best food safety practices. The Canadian government estimates 1 of ev... Read More

TWiV 390: Building a better mosquito trap

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Etha... Read More

TWiV 393: Lovers and livers

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

Hosts:  Read More

TWiM 133 Letters

Arthur writes:

Hello TWIMers!

I'm a graduate student working in mycoplasmology and I  must say I've been overjoyed to hear the past few episodes mention our tiny friends!

Elio's mention of their unique mechanism of moving ("Gliding Motility") made... Read More

TWiM 129 Letters

Steven writes:

Dear Vincent et al,

Firstly, congratulations for keeping up such a wide range of thought provoking podcasts, and maintaining such a tremendous output. I find they all leave me with more questions than answers, which is, I think, a sign of good s... Read More

BacterioFiles 262 - Pathogen Polyketide Protects and Punishes

This episode: Clostridium bacteria that infect potatoes can both kill competitors and tolerate oxygen, thanks to the pink compounds they produce!

(12.4 MB, 13.5 minutes)

Show notes: 
Journal Paper:

Read More

TWiP 112: A NOD to a tricky helminth

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.

Hosts:  Read More

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