This episode: Bacteria in hydrothermal vents that feed their host tubeworms evacuate when their hosts perish!
(9 MB, 9.8 minutes)
The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.
The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella.
Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation, cleavage and packaging of viral DNA genomes.
Host: Vincent Racaniello
Guest: ... Read More
Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.
The anaerobic, Gram-positive Clostridium difficile is a big problem. It causes rampant diarrhea and tissue necrosis, with more than 150,000 annual cases in the United States alone. Many of the disease manifestations of C. difficile are mediated by two exotoxins that C. difficile produces: TcdA a... Read More
In systems biology studies, the integration of multiple omics measurements (i.e., genomics, transcriptomics, proteomics, metabolomics, and lipidomics) has been shown to provide a more complete and informative view of biological pathways. Thus, the prospect of extracting different types of molecu... Read More
If it looks like a duck and quacks like a duck, it’s likely a duck – so goes the saying that illustrates the simplest explanation is usually the right one. But what about duck decoys used in conjunction with bird calls? Misidentification can be a deadly error – and the same goes for microbes. Mi... Read More
As we highlighted in our previous blog, antibiotic stewardship – the careful use of appropriate antibiotic administration – can have positive effects. A small change from a difference in clinical lab reporting led to less drug use, which led to fewer drug-resistant infections. When we think of a... Read More
Microbial communities are essential drivers of soil functional processes such as nitrification and heterotrophic respiration. Although there is initial evidence revealing the importance of soil type in shaping microbial communities, there has been no in-depth, comprehensive survey to robustly es... Read More
There’s no way to avoid the news of a growing concern for drug-resistant infections. In both life-threatening and relatively superficial infections, the ability to successfully treat microbial infections with antimicrobials is decreasing. Our only recourse is to use the drugs we have carefully w... Read More
This episode: I converse with Dr. Michael Smout about a liver fluke parasite could help heal chronic wounds more quickly!
(13.4 MB, 14.6 minutes)
Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.
Host: Vincent Racaniello
Gue... Read More
Colony collapse disorder (CCD) has caused such a profound drop in honeybee populations that even the U.S. Congress is addressing the issue: Senator Jeff Merkley (D-Oregon) has proposed the Pollinator Recovery Act to preserve pollinator habitat. The rapid decline in these important pollinators af... Read More
Marine plastic debris is a growing concern that has captured the general public’s attention. While the negative impacts of plastic debris on oceanic macrobiota, including mammals and birds, are well documented, little is known about its influence on smaller marine residents, including microbes t... Read More
A central pursuit of microbial ecology is to accurately model changes in microbial community composition in response to environmental factors. This goal requires a thorough understanding of the drivers of variability in microbial populations. However, most microbial ecology studies focus on the ... Read More
Imitation may be the sincerest form of flattery, but it can also be the easiest way to make a buck. That’s the primary motivation for camouflaging within an already-established brand: Sunbucks, McDowell’s, and Mountain Lightening all rely on brand recognition – of a brand that isn’t their own. W... Read More
This episode: Bacterial toxins could be modified to deliver life-saving proteins into neurons!
(11.1 MB, 12.1 minutes)
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.
Host: Vincent Racaniello
Guest:&nbs... Read More
Although the Gram-negative bacterium Vibrio cholerae (right) is normally associated with human pathogenic disease, most V. cholerae cells spend their lives in an aquatic environment, and only a few of the many serotypes are able to cause disease. When strains acquire the right genetic makeup – s... Read More