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Click-Chemistry Labeling of Oligonucleotides and DNA - Lumiprobe - Protocol


Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecules can be involved, and labeling with small molecules, such as fluorescent dyes, biotin, and other groups can be readily achieved.

Click chemistry reaction takes pl... Read More

Interview of Dr. Tim Sandle

Q) Dr. Tim Sandle, the well known researcher, professor, author and science communicator. It is much interesting for me to take an interview of an eminent person who is well known for the communicating science. Starting from your early childhood life, how you used to take science as that time?
... Read More

HIV gets the zinc finger

Because all animal viruses initiate infection by binding to a receptor on the cell surface, this step has long been considered a prime target for antiviral therapy. Unfortunately, drugs that block virus attachment to cells have never shown much promise. Another approach, which is to ablate the r... Read More

TWiV 276: Ramblers go viral



 Host: Vincent Racaniello


Guests: Sus... Read More

TWiM #74: It came from the Siberian permafrost

Hosts: Vincent RacanielloElio Schaechter, and Michael Schmidt


Vin... Read More

Attenuated influenza vaccine enhances bacterial colonization of mice

Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More

Breathing New Life into DNA Microarrays

DNA microarrays are widely used in biological research and were once thought to be a very promising gene discovery tool. However, since the advent of next generation DNA sequencing, the popularity of DNA microarrays has steadily declined. Compared to the sequencing, microarray behavior is unce... Read More

BacterioFiles Micro Edition 158 - Partners Provide Protein

This episode: Different bacteria working together can thrive better than when working alone!


(9.9 MB, 10.75 minutes)


Show notes: 
News item/ Read More

TWiV 275: Virocentricity with Eugene Koonin



 Hosts: Vincent Racaniello and Rich Condit Read More

TWiP 68 letters


Tim writes:


I listened to the latest TWIP this morning. Dickson mentioned the herbicide atrazine but thought it was a fungicide. It is actually a herbicide in the photosynthesis inhibitor class. Another bit of trivia about ag chemicals is that old chemicals like ... Read More

TWiP 68: Sex and the single trypanosome



Hosts: Vincent Racaniello Dickson Despommier, and Read More

Mundo de los Microbios - Episodio 107 - Delfina Urbina

Uno de los patógenos más importantes en América Latina y seguramente el mundo entero, el rotavirus, es discutido en este episodio de La Radio El Mundo de los Microbios. La Prof. Delfina Urbina, con una larga trayectoria en diferentes áreas de la Microbiología nos visita hoy. Fué Profesora Tit... Read More

Pithovirus: Bigger than Pandoravirus with a smaller genome

A new virus called Pithovirus sibericum has been isolated from 30,000 year old Siberian permafrost. It is the oldest DNA virus of eukaryotes ever isolated, showing that viruses can retain infectivity in nature for very long periods of time. Read More

BacterioFiles Micro Edition 157 - Azotobacter Assists Algae

This episode: Nitrogen-fixing bacteria could provide nitrogen to algae in biotech processes!


(7.4 MB, 8 minutes)


Show notes: 
Journal... Read More

TWiV 274: Data dump



Hosts: Vincent Racaniello, Dickson Despommier, Read More

TWiM #73: Eyeing root nodule development

Hosts: Vincent RacanielloMichael Schmidt and Michelle Swanson Read More

TWiM 73 Letters

Mark writes:


Hello Team TWiM,


I’ve followed with interest your coverage of Michael’s research into use of copper to fight hospital infection. Of all the interesting papers covered in 2013, I think the one most actionable is episode 55, The Copper Room. His res... Read More

Polio-like paralysis in California

Recently a number of children in California have developed a poliomyelitis-like paralysis. The cause of this paralysis is not yet known, and information about the outbreak is scarce. However, acute-flaccid paralysis is not uncommon (California would be expected to report about 75 cases a year, b... Read More

TWiV special: MERS-coronavirus in dromedary camels



Host: Vincent Racaniello


Guests: Read More

MERS Virus Widespread in Saudi Arabian Camels (News Release)

The coronavirus responsible for Middle East Respiratory Syndrome (MERS) is prevalent in camels throughout Saudi Arabia and has been around for at least 20 years, according to a study to be published in mBio®, the online open-access journal of the American Society for Microbiology.

“Our study ... Read More

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