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This Week in Virology

twiv

This Week in Virology (TWiV) is a podcast – or netcast, as some prefer to call them, since you don’t need an iPod to listen – about viruses. It was begun in September 2008 by Vincent Racaniello and Dick Despommier, two science Professors at Columbia University Medical Center. Their goal was to have an informal yet informative conversation about viruses which would be accessible to everyone, no matter what their science background. We wanted to eventually bring other virologists into the conversation, to make it more varied and interesting. Alan Dove, a science writer, joined us late in 2008, and Rich Condit, a poxvirologist, joined in 2009. We’ve had a number of guests on the show and we’re always trying to get more.

Why are we doing this? Dick, Rich, and I have spent our entire academic careers directing research laboratories, so we have a lot of knowledge to share. Plus, we both enjoy teaching. Put those two things together, and you have TWiV. If you want to learn about viruses in a relaxing way, then TWiV is for you.

TWiV 222: Jumpin' Jack Flash, it's a GAS GAS GAS

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Hosts: Vincent Racaniello, Rich ConditDickson Despommier, Alan Dove, and Kathy Spindler

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

Download TWiV 222 (70 MB .mp3, 97 min)

Subscribe (free): iTunesRSSemail

Links for this episode:cgamp

Weekly Science Picks

Kathy - Graphene batteries
Alan - How do we get cures? (YouTube)
Rich -
Explosive breach of Condit Dam (Vimeo)
Vincent
-  10 things you can do to support open access (Tree of Life)

Listener Pick of the Week

Mark - The real story of Stuxnet
John - D-connector virus

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TWiV 221: Bunya there, done that

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Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler

Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.

Download TWiV 221 (66 MB .mp3, 91 min)

Subscribe (free): iTunesRSSemail

Links for this episode:sbv infectious dna

Weekly Science Picks

Kathy - Winners, 2012 Science & Engineering Visualization Challenge
Vincent -  The Operator and Dr. Oz's Problem

Listener Pick of the Week

Shane - OpenPCR
John - Python

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TWiV 220: Flu watches the clock while T7 gets a CAT scan

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Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.

Download TWiV 220 (69 MB .mp3, 95 min)

Subscribe (free): iTunesRSSemail

Links for this episode:random walk

Weekly Science Picks

Kathy - Journal of Virology Image Gallery
Rich - Phage T7 Genetics and Physiology and slab gels
Alan - PeerJ (press release)
Vincent -  Virologia en Español

Listener Pick of the Week

Dave - Thingiverse pathogens and proteins 

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TWiV 219: Fauci pharmacy

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Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci

Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.

Download TWiV 219 (46 MB .mp3, 64 min)

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Links for this episode:IMG 3142

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TWiV 218: Monkeys turning valves and pushing buttons

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Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson

Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.

Download TWiV 218 (64 MB .mp3, 89 min)

Subscribe (free): iTunesRSSemail

Links for this episode:bakugan

Weekly Science Picks

Welkin - Viruses: Essential Agents of Life (review at STC)
Alan - Infinity Imagined
Vincent - Spaceship built for son

Listener Pick of the Week

Amanda - Written? Kitten!
Kevin - Protein synthesis: An epic (YouTube)
Daria - The Baltimore Scheme  

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TWiV 217: I just flu in and my arms are shot

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier

Vincent, Alan, Rich, and Dickson review influenza vaccines.

Download TWiV 217 (69 MB .mp3, 95 min)

Subscribe (free): iTunes, RSS, email

Links for this episode:vaccine vial

Weekly Science Picks

Rich - Repoopulate (original article), Robogut (new clinical trial)
Alan - WTF, Evolution?
Dickson - The Beauty and Benefits of Science
Vincent - Supercomputing modeling of poliovirus

Listener Pick of the Week

Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram

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TWiV 216: Processing VIRALGUUAACACCAGRNA

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.

Download TWiV 216 (67 MB .mp3, 93 min) 

Subscribe to TWiV (free): iTunesRSS feedemail

Links for this episode:

Weekly Science Picks

Rich - Linus Pauling's explanation of science (YouTube)
Alan - Underwater experiments
Kathy - I'm a virus (YouTube)
Vincent - Stem cells(Bizarro Comics)

Listener Pick of the Week

Tom - The President's Analyst
Danielle - Overly honest methods (HuffPost and ASBMB Today)

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TWiV 215: Illuminating rabies and unwrapping a SARI

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Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.

Download TWiV 215 (66 MB .mp3, 92 min)

Subscribe to TWiV (free): iTunesRSS feedemail

Links for this episode:virus in the garden

Weekly Science Picks

Alan - I'm a Scientist - The Film
Kathy - Humorous units of measurement (Wikipedia)
Vincent - Open access must enable open use (Nature)

Listener Pick of the Week

Tarwin - Plague Inc.

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TWiV 214: This is your brain on polyomavirus

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Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.

Download TWiV 214 (56 MB .mp3, 78 min)

Subscribe to TWiV (free): iTunesRSS feedemail

Links for this episode:raccoon tumor

Weekly Science Picks

Alan - Parasite of the Day
Kathy - Tour of International Space Station
Vincent - Earth as Art

Listener Pick of the Week

Robin - Angell on Big Pharma
Michael - Flu jokes
Jim - Database of Ted talks; Downloadable Ted Talks

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TWiV 213: Not bad for a hobby

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Hosts: Vincent Racaniello, Rich ConditAlan Dove, and Kathy Spindler

In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012.

Download TWiV 213 (88 MB .mp3, 122 min)

Subscribe to TWiV (free): iTunesRSS feedemail

Twelve virology stories from 2012:neidl-twiv

  1. H5N1 (TWiV 190, 182, 177, 173, 168)
  2. Polymorphisms that control susceptibility (TWiV 175, 180)
  3. New virus receptors (TWiV 166, 210)
  4. XMRV: Last nail in the coffin (TWiV special)
  5. Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog)
  6. Biomedical research crisis (TWiV 208184189194)
  7. Polydnaviruses in parasitoid wasps (TWiV 179)
  8. Carolyn Coyne’s placental barrier story (TWiV 193)
  9. Touring NEIDL (TWiV 200)
  10. Epidemiology (TWiV 169, 178)
  11. A good year for virus hunting (173, 183, 195, 196, 198, 199, 204)
  12. Pox accordion (TWiV 198)

Links for this episode:

Weekly Science Picks

Rich - Our Mr. Sun (IMDB entry) (wiki)
Alan - PubReader from NCBI announcement and instructions
Kathy - Popular Mechanics 110 picks for the next 110 years
Vincent - 366 days: Nature's 10

Listener Pick of the Week

Matt - The flu vaccine controversy

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