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TWiP 24 Letters

Betsy writes:

Dr.'s Racaniello and Despommier,

Hello! To start off like so many of the messages you receive thank you so much for this wonderful podcast! I'm a huge fan of both TWIP and TWIV and have listened to every episode to date in both. It's fantastic how you present all of the information in a conversational way that is understandable for such a diverse audience of listeners. You two, along with your cohorts on TWIV, continue to feed my interest and very very limited knowledge in the fields of parasitology and virology.

I am a medical and biological illustrator/animator who became very interested in the field of parasitology while working on my graduate thesis at the Johns Hopkins University School of Medicine. My preceptor, Dr. Rhoel R. Dinglasan, an associate professor at the Johns Hopkins School of Public Health (JHSPH), who besides being incredibly intelligent and enthusiastic, sparked my fascination with the malaria parasites, and the field in general. And thanks to you I can continue to stay up to date and expand my knowledge in this field.

That being said I thought you might enjoy the new issue of the JHSPH magazine. It's all about malaria! I really enjoyed articles and reading about what research is being done and also why some of the researchers focus on various aspects of combating this disease, such as control vs. eradication. Plus there is the main illustration that beautifully depicts the life cycle of the malarial parasite that was created by an incredible medical illustrator Jennifer E. Fairman. There is an interactive version of this illustration on the magazine site too. To view this issue please follow the link below:

I thought that you would enjoy this illustration too as you have mentioned aspects of my field on both your podcasts in the past. Specifically you have commented on molecular animations by David Bolinsky of XVIVO who is at the top of the field in this area. You might already know about this but in case you do not, the web site showcases some of the most beautiful molecular animations out there. This site has a two-part animation by another amazing medical animator, Drew Berry, on the life cycle of the malarial parasite. Don't despair Dr. Racaniello there are many animations on there about viruses there too!

Again thank you for putting all of the time and effort that it must take to prepare and deliver such a fantastic podcast! I'm looking forward to all of your future episodes!



P.S. In appreciation for your sharing of knowledge and enthusiasm for science I've attached an illustration of mine for you of the malaria life cycle with in the mosquito. I know it's not enough to repay you for your generous service but it's a start.

Weissbrod Studios

Helen writes:

I am a med tech and a member of a group of people with immune diseases who is interested in helminithic therapy. We listened with great interest to the TWIP on Trichuris trichiura, which some of us are already using. I wanted to ask you when you will be covering hookworm, and if you could discuss the therapeutic benefits of Necator americanus, which some of us are also using. I liked the Trichuris podcast so much I am going back and listening to all the old episodes. I am interested in how trichinella could be used therapeutically. I believe you said that if the larvae are injected directly into skeletal muscle, they would immediately infect the muscle cells. Would this mean that by bypassing the migration phase, the infection would not cause pathology?

I have a family member with eosinophilic esophagitis, which is a disease that fits the hygiene hypothesis perfectly: sudden recent increase in incidence, atopic disease, more common in children, and the eosinophilic response is supposed to fight off parasites. This is a horrible disease that causes much suffering and often leaves the person unable to tolerate any food, needing a feeding tube and elemental formula. Do you know anything about the incidence of this disease compared to the incidence of parasites worldwide?

Keep up the good work,

Rich writes:

Hi TWiP fellas,

I should be working but I'm procrastinating by writing you.

I'm finally hooked on TWiP. Great show. Sorry it took a while. Until now my taste in podcasts has been a bit narcissistic.

I know this is a family show, but I really need to know if tapeworms have sex. You keep talking about "eggs" but my sense is that these are not haploid nor are they zygotes, but rather multicellular larvae encased in a shell. Right?

So do tapeworms have a haploid phase? Are there sexes? Assuming there is a haploid phase, when, where and how during the life cycle does fertilization take place? If tapeworms are hermaphrodites, do they self-fertilize, or is there a chance to mix it up with other worms, or both?

Thanks and keep up the good work.


Richard Condit
Department of Molecular Genetics & Microbiology
University of Florida
Gainesville, FL

Laura writes:

Hiya im Laura from the UK, studying Zoology and wanting to comtinue onto an MSc in parasitology. I was wondering are there parasites of parasites? would microsporidia be a cadidate for this?

Ryan writes:


Just wanted to drop you guys a line and let you know I enjoyed the podcast. I found TWiP while actually looking for a podcast about photography, but gave it a listen anyways. I'll be downloading every episode from now on. Parasitology was my favorite class as a undergrad. Thanks for the work you do!


Todd writes:

Hey Docs!

I'm a computer programmer who listens to podcasts on my long commute. The highest science education that I've had was college Chemistry. As an Electrical Engineer the science classes we took tended to not be biology oriented, so while some of it is over my head, to say that I find biotech and molecular biology fascinating is an understatement.

On to my question: I was born in 1970 in southern Louisiana. My uncle had a horse and we (me, my Dad, my uncle) would scoop the manure out of the stall and put it into a pile on the side of the horse barn. Some months later, after the manure had been exposed to the weather and sun-dried, we'd scoop it into the wheelbarrow and put it, along with composted grass clippings, in the garden as we tilled the soil for planting. I was wondering what kind of worms and/or other parasites we might have been exposed to by using horse manure to fertilize our vegetable garden. If I'm understanding things correctly, I don't think there is any danger from worms lasting long enough to get into our veggies and infect
us, but what about direct contact when handling the sun-dried manure (shovels and gloves, but still "stuff" happens)? And is there really anything to fear other than worms? I am in good health, so I think the answer is probably no, I'm just learning for learning's sake.

P.S. Lately I've been listening to the FiB, TWiV, and TWiP podcasts to the point where I'm neglecting my techie podcasts. You guys are causing me to lose some of my geek creds :-)

Regards... Todd


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