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TWiP 94: Loa hanging fruit

Vincent, Dickson, and Daniel solve the case about the man from El Salvador, and discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Download TWiP #94 (74 MB .mp3, 102 minutes).

Links for this episode:Bcr abl STI 1IEP

Case study for TWiP 94

Daniel's patient was seen in the clinic. He is a 33 yo chinese male, from Chinatown NYC, for several months on and off has had watery diarrhea, headaches. Tried reflexology, chiropractic therapy, with no results. Has traveled quite a bit, been in Chile (was there a few months before). Came to US when young. Grew up in the US. In Chile, has had many sexual partners, >50, of both sexes, also has done many drugs. Two years ago was diagnosed with chronic HIV, CD4 count 685, on ARVs triple therapy, virus loads are well controlled. Has had syphilis, nose job, no medication allergies. Lives with family. On exam, afebrile, looks well. Symptom onset a few months after last Chile visit. Is an adventurous eater.

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Comments (1)

  1. Note that the tyrosine kinase inhibitors discussed in this episode are small molecules - not mAbs as we said. Mea culpa! You can see from the image the red molecule, which is the inhibitor, is clearly not an antibody. Sorry.

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