ASM Live Archives
Trypanosome Lytic Factor (TLF) has emerged as a novel arm of innate immunity that is only present in humans and select non-human primates. TLF was originally discovered in human blood as a minor form of High-density lipoprotein (HDL), also known as a good cholesterol, that rapidly kills the African trypanosome, Trypanosoma brucei, thereby making humans resistant to infection. Participants will discuss this finding as well as how understanding these mechanism will provide insights as to other pathogens that TLF should kill, as well as offer potential avenues to therapeutically augment or mimic TLF action.
- Jayne Raper, Hunter College, New York, NY, United States