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Researchers Find Novel Signature in the Brains of Children with Cerebral Malaria: Disease exacerbated by HIV

Washington, DC - September 22, 2015 - Cells associated with inflammation and blood clotting accumulate in the brain blood vessels of children affected by a potentially fatal form of malaria called cerebral malaria (CM), potentially contributing to the disease process, an international team of re... Read More

TWiP 99 letters

 


Mark writes:


Temperature in Oklahoma is 12 degrees C today and rainy.


My guess is Tunga penetrans which is native to South America. The black point at center of itchy toe lesion is the flea which are legs, spiracles and egg laying aparatus. Fema... Read More

ASM Live at #ICAAC / ICC - Silicone Vaginal Rings Deliver Antiviral Drugs, Protect Women against HIV

Meriam Memmi, PhD candidate at University Jean Monnet of Saint-Etienne, France discusses her research which led the creation of a new birth control device with additional protective properties against sexually transmitted infections (STIs). STIs of viral origin constitute a major public health c... Read More

Single dose Ebola vaccine is safe and effective in monkeys against outbreak strain

National Institutes of Health (NIH) scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if giv... Read More

TSRI & Janssen study makes major advance toward more effective, long-lasting flu vaccine

LA JOLLA, CA - August 24, 2015 - Scientists from The Scripps Research Institute (TSRI) and the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) have found a way to induce antibodies to fight a wide range of influenza subtypes--work that could one day eliminate the need for repeate... Read More

Expression of a single gene lets scientists easily grow hepatitis C virus in the lab

Worldwide, 185 million people have chronic hepatitis C. Since the late 1980s, when scientists discovered the virus that causes the infection, they have struggled to find ways to grow it in human cells in the lab -- an essential part of learning how the virus works and developing new effective tr... Read More

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a bri... Read More

The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory ā€“ a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

HIV particles do not cause AIDS, our own immune cells do

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. Read More

Zika virus and microcephaly

Three reports have been published that together make a compelling case that Zika virus is causing microcephaly in Brazil. Read More

Romidepsin can reverse HIV latency in patients on long-term ART

A cure for HIV requires the eradication of latent (i.e., dormant and therefore hidden) virus from reservoirs in immune cells throughout the body. HIV latency depends on the activity of proteins from the human host called histone deacetylases (HDAC), and previous work has shown that HDAC inhibito... Read More

Virus-like particle vaccine protects mice from many flu strains

A vaccine that protects against a wide variety of influenza viruses (a so-called universal flu vaccine) is a critical public health goal given the significant rates of illness and death caused by seasonal influenza and the potentially devastating effects of a pandemic influenza strain. Now, rese... Read More

TWiP 105: Survival of the fattest

The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity.


Hosts: Vincent Racaniello Read More

Study points to a possible new pathway toward a vaccine against MRSA

New research led by NYU Langone Medical Center has uncovered why a particular strain of Staphylococcus aureus -- known as HA-MRSA -- becomes more deadly than other variations. These new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Di... Read More

Why West Nile virus is more dangerous in the elderly

West Nile virus (WNV) is particularly dangerous in older people, who account for a large number of severe cases and deaths caused by the virus. WNV infection turns serious when the virus crosses the blood-brain-barrier and wreaks havoc among nerve cells in the brain. A study published on July 23... Read More

Scripps research-designed drug candidate significantly reduces HIV reactivation rate

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS. Read More

Crime-scene compound may be newest tool in fight against malaria

The compound that detectives spray at crime scenes to find trace amounts of blood may be used one day to kill the malaria parasite. Read More

Bacteria in ancient flea may be ancestor of the Black Death

CORVALLIS, Ore. - About 20 million years ago a single flea became entombed in amber with tiny bacteria attached to it, providing what researchers believe may be the oldest evidence on Earth of a dreaded and historic killer - an ancient strain of the bubonic plague. Read More

Permissive vaccines and viral virulence

A permissive vaccine prevents disease in the immunized host, but does not block virus infection. Would a permissive vaccine lead to the emergence of more virulent viruses?

This hypothesis is based on the notion that viruses which kill their hosts too quickly are not efficiently transmitted, a... Read More

TWiV 379: A mouse divided

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

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