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Treatment of Ebola virus infection with brincidofovir

The Liberian man who was diagnosed with Ebola virus infection after traveling to Dallas, Texas, was treated with an antiviral drug called brincidofovir. This drug had originally been developed to treat infections with DNA-containing viruses. Why was it used to treat an Ebola virus infection? Read More

The incubation period of a viral infection

The time before the symptoms of a viral infection appear is called the incubation period. During this time, viral genomes are replicating and the host is responding, producing cytokines such as interferon that can have global effects, leading to the classical symptoms of an acute infection (e.g.... Read More

Acute flaccid paralysis of unknown etiology in California

In February 2014 I wrote about children in California who developed a poliomyelitis-like paralysis, also called acute flaccid paralysis or AFP. However, the cause of this paralysis was not known. The CDC has released its study of these cases and concludes “The etiology of AFP with anterior myeli... Read More

Studies Examine Vaccination Strategies For Prevention, Control of Avian Flu - press release

Two randomized trials in the October 8 issue of JAMA examine new vaccination strategies for the prevention and control of avian influenza, often referred to as “bird flu.” This is a theme issue on infectious disease.

In one study, Mark J. Mulligan, M.D., of the Emory University School of Medi... Read More

Liquid DNA behind virus attacks

Viruses can convert their DNA from solid to fluid form, which explains how viruses manage to eject DNA into the cells of their victims. This has been shown in two new studies carried out by Lund University in Sweden.

Both research studies are about the same discovery made for two different vi... Read More

Could Multiple Sclerosis Begin in the Gut?

Multiple sclerosis (MS) is an electrical disorder, or rather one of impaired myelin, a fatty, insulating substance that better allows electric current to bolt down our neurons and release the neurotransmitters that help run our bodies and brains. Researchers have speculated for some time that th... Read More

HIV pandemic's origins located

The HIV pandemic with us today is almost certain to have begun its global spread from Kinshasa, the capital of the Democratic Republic of the Congo (DRC), according to a new study.

An international team, led by Oxford University and University of Leuven scientists, has reconstructed the genet... Read More

New vaccines targeting adults, teens are best chance to eliminate TB by 2050

Targets to eliminate tuberculosis by 2050 are more likely to be met if new vaccines are developed for adults and adolescents instead of for infants, according to new research.

Researchers at the London School of Hygiene & Tropical Medicine and the Stop TB Department at the World Health Organi... Read More

‘Programmable’ antibiotic harnesses an enzyme to attack drug-resistant microbes

The multitude of microbes scientists have found populating the human body have good, bad and mostly mysterious implications for our health. But when something goes wrong, we defend ourselves with the undiscriminating brute force of traditional antibiotics, which wipe out everything at once, rega... Read More

Spain Confirms First Ebola Transmission Outside of Africa

Health authorities in Spain have confirmed that a health worker at the Carlos III Hospital in Madrid, Spain has been infected with the Ebola virus. This is the first time anyone has contracted the virus outside of Africa.

The woman, a nurse technician, had worked in the room where two Ebola p... Read More

Chromosome Organization the Pseudomonas Way, Part 1

(Re-)Introducing the Pseudomonads. Despite the somewhat murky provenance of their name, pseudomonads are everything but "pseudo-" in terms of their metabolic versatility: they are bacterial omnivores, heterotrophs yet far from picky. Members of the family Pseudomonadaceae (Gammaproteobacteria) a... Read More

BacterioFiles 185 - Bacteroid Builds Beta-lactam Buffer

This episode: Antibiotic-degrading probiotics protect mouse gut microbes from hostile pathogen takeover after antibiotic treatment!


(7.8 MB, 8.5 minutes)


Show notes: 
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Manure Fertilizer Increases Antibiotic Resistance

Treating dairy cows and other farm animals with antibiotics and then laying their manure in soil can cause the bacteria in the dirt to grow resistant to the drugs. But a study now suggests that the manure itself could be contributing to resistance, even when it comes from cows that are free of a... Read More

A novel roadmap through bacterial genomes leads the way to new drug discovery

For millennia, bacteria and other microbes have engaged in intense battles of chemical warfare, attempting to edge each other out of comfortable ecological niches. Doctors fight pathogens with an arsenal of weapons—antibiotics—co-opted from these microbial wars, but their efforts are frustrated... Read More

Discovery on how fungi avoid immune responses of plants leads to new generation of fungicides

Plants that come under attack from pathogens have an automatic immune response. Fungi get around this plant immunity by injecting proteins into the host plant cells. These 'effector proteins' enable the fungi to escape the plant's immune system and allow the fungal cells to enter the plant unrec... Read More

TWiV 305: Rhymes with shinola

Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.


Hosts:  Read More

Special bacteria, 13000 cleaners to clean Dhaka

Dhaka City Corporation will engage around 13,000 cleaning staffs and special bacteria to keep the capital clean during Eid-ul-Azha festival.

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This large number of cleaning staff will work round the clock for 48 hours. Apart from that, t... Read More

Patterned progression of bacterial populations in the premature infant gut

(Interesting study from PNAS)

It is increasingly apparent that bacteria in the gut are important determinants of health and disease in humans. However, we know remarkably little about how this organ transitions from a sterile/near-sterile state at birth to one that soon harbors a highly dive... Read More

Yogurt bacteria could replace colonoscopies for cancer detection

Let's face it: colonoscopies are pretty unpleasant. But what if you could eat a spoonful of yogurt to check for cancer rather than enduring that procedure? MIT professor Sangeeta Bhatia is working on engineered bacteria that detects colorectal cancer. Read More

Ebola Patient’s Journey Shows How Global Travel Spreads Disease

The arrival in the United States of a Liberian man infected with the Ebola virus shows how easily the disease can travel and how thin the procedures are, relying heavily on the honesty of travelers and the diligence of airport workers. Some experts say that the system, given its inherent weaknes... Read More
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