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MWV Episode 94 - TWiM #99: Careers in Biodefense
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Global Fund Needed to Fight Dangerous Superbugs

A global fund should be created to speed development of much-needed new antibiotics to counter the growing threat of drug-resistant superbugs, a British-government backed review said on Thursday.

The review, headed by the leading economist and former Goldman Sachs chief Jim O'Neill, said far ... Read More

TWiM #97: There’s gold in them hills

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

TWiM 97 Letters


Dennis writes:
hi Doc,


A paper just published in nature:


http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14098.pdf


reports an effective antibiot... Read More

Cyanobacterium found in algae collection holds promise for biotech applications

Cyanobacteria could serve as a synthetic biology chassis that could be retooled for the production of biofuels, drugs or chemcials. So far, however, they have been held back by sluggish growth that makes it difficult to conduct the initial experiments needed to characterize their genetic and met... Read More

BacterioFiles 200 - Converted Clostridium Consumes Carbon monoxide

This episode: Carbon monoxide-eating bacteria get modified to produce more useful products!


(16 MB, 17.5 minutes)


Show notes: 
Journal Paper


... Read More

A Possible Treatment for Peanut Allergies

More than 15 million people in the United States live with food allergies that impact every meal they eat. For some, accidentally ingesting a snack that their body deems taboo can ignite a violent biological response. Every three minutes someone is rushed to the emergency room due to a food alle... Read More

Meet Dr. Armpit, Changing Body Odor With Bacteria

Here’s an undeniable fact: In samples collected from seven of New York’s subway platforms, scientists discovered that we're surrounded in plumes of microbes wafting off other people’s skin. Here’s another undeniable fact: Those bacteria colonize all of our glands and follicles and the entire epi... Read More

Green tea ingredient may target protein to kill oral cancer cells

A compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.

Earlier studies had shown that epigallocatechin-3... Read More

Gut Bacteria Byproduct Linked to Chronic Kidney Disease for the First Time

Cleveland Clinic researchers have, for the first time, linked trimethylamine N-oxide (TMAO) – a gut metabolite formed during the digestion of egg-, red meat- or dairy-derived nutrients choline and carnitine – to chronic kidney disease.

TMAO has been linked to heart disease already, with blood... Read More

Obama tells parents to get kids vaccinated to stem measles

President Barack Obama is urging parents to get their children vaccinated in the face of a measles outbreak that has infected more than 100 people in the United States.

He said that while he understood there were families concerned about the effect of vaccinations, he said the science was "pr... Read More

Ebola Drug Trial Is Halted for Lack of Patients

A clinical trial in Liberia of a drug to treat Ebola has been halted because of a sharp decline in the number of people infected with the virus, and studies in West Africa of other potential treatments are also facing problems finding patients.

The halted trial was testing the antiviral drug ... Read More

Interview of Dr. Vincent Racaniello - Journey with Virus

Dr. Vincent Racaniello is the Higgins Professor of Microbiology and Immunology at the college of Physicians and Surgions of Columbia University. Along with his academic research, he is known for expanding knowledge with great contributions through his virology blog virology.ws, and his wide podc... Read More

TWiV 322: Postcards from the edge of the membrane

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

Infectious agents with no genome

If the reader does not believe that viroids and satellites are distinctive, then surely prions, infectious agents composed only of protein, must impress.

The question of whether infectious agents exist without genomes arose with the discovery and characterization of infectious agents associat... Read More

Among gut microbes, strains, not just species, matter

A large community of microorganisms calls the human digestive tract home. This dynamic conglomerate of microscopic life forms - the gut microbiome - is vital to how people metabolize various nutrients in their food, how their immune systems react to infection, and how they respond to various med... Read More

How we used to talk about Measles

These days, the happiest place on Earth isn't so cheerful. In December, a large number of people started coming down with measles after visiting Disneyland in California. So far, about 80 measles cases have been reported in the state, an unusually large number for a virus that has long been unde... Read More

Bacteria May Remain Dormant After UV Disinfection

Many drinking water treatment facilities worldwide disinfect water with ultraviolet light because it’s quick and efficient, kills protozoa such as Giardia, and doesn’t introduce potentially harmful disinfection by-products. But a new study shows that UV treatment alone can push bacteria into a d... Read More

Make the Pause on Risky Pathogen Research Permanent

Last October the White House announced a pause in federal funding for so-called gain-of-function experiments that increase the contagiousness or virulence of influenza viruses or of the coronaviruses that cause severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS). ... Read More

How Listeria Breaches the Placenta

A gut bacterium called Listeria (Listeria monocytogenes), which is often found in soft cheese, is known to present a risk to pregnant women. Listeria uses distinct tactics to breach the intestine and the placenta, using a protein called phosphoinositide-3 kinase (PI3-K), according to a study pub... Read More

Obama to seek more funds for antibiotic-resistant bacteria fight

President Barack Obama will request a doubling of funds for fighting and preventing antibiotic-resistant bacteria in his 2016 budget, the White House said Tuesday.

The goal is to expand US investment in developing of antibacterial and new rapid diagnostics and launch a major effort to charact... Read More
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