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First case of acute myelitis in a patient infected with Zika virus

A first case of acute myelitis following infection with Zika virus has been reported for the first time by a research team from Inserm Unit 1127 Brain and Spinal Cord Institute (Inserm/CNRS/Sorbonne University) and neurologists at Pointe-à-Pitre University Hospital and the University of the Anti... Read More

TWiM 134 Letters

Nathan writes:
Dear Vincent, Elio, Michele & Michael,
Thank you all for the wonderful podcast!  It’s a great gift to humanity and science communication.  It would be great if you could discuss the really interesting paper by Din et al recen... Read More

Multi-tasking Flu Vaccine Could Provide Better Protection against Outbreaks

Washington, D.C.—October 27, 2015—Australian researchers have found a way to boost the effectiveness and cross-protective capabilities of an influenza A vaccine by adding a simple component. Published this week in mBio, an online open-access journal of the American Society for Microbiology, the ... Read More

Hospitals overlook every other person with HIV

A new study reveals that many European hospitals fail to routinely test people who may be at risk of an HIV-infection. If tests were more widely offered in the healthcare system, fewer HIV-patients would go unnoticed, especially in Northern Europe. Read More

Georgetown researcher leads effort to decode anti-malarial drug resistance

WASHINGTON (Dec. 16, 2015) -- Even as the global malarial pandemic appears to be on a decline, drug resistant malarial parasites are on the rise, says an infectious disease researcher at Georgetown University Medical Center, who is taking the lead on a multi-institutional effort to investigate t... Read More

Researchers hope hybrid compounds can sensitize and inhibit malaria parasites in one blow

Because of its safety, efficacy, and affordability, chloroquine remains the treatment of choice for all Plasmodium species, except in regions with chloroquine-resistant P. falciparum. Chloroquine-resistant protists are treated with combination therapy, which includes artemisinin-derived molecule... Read More

Curcumin may help overcome drug-resistant tuberculosis

New research indicates that curcumin--a substance in turmeric that is best known as one of the main components of curry powder--may help fight drug-resistant tuberculosis. In Asia, turmeric is used to treat many health conditions and it has anti-inflammatory, antioxidant, and perhaps even antica... Read More

Ferreting out an improved Ebola animal model

We’ve previously covered the importance of diagnostics in disease control and treatment. This is vital to controlling disease progression and transmission, but epidemiology studies can’t always show how a disease progresses or transmits. This is where scientists need a well-characterized animal ... Read More

New drug class offers potential new treatment for lethal bacteria

A new class of drugs has shown promise for treating the bacteria that cause legionnaires' disease, a potentially fatal lung infection. Read More

First-in-man trial of MERS vaccine begins at Walter Reed Army Institute of Research

SILVER SPRING, Md. - The Walter Reed Army Institute of Research (WRAIR) began vaccinations today in a Phase 1 clinical trial to evaluate the safety and immune response of a vaccine candidate to prevent Middle East Respiratory Syndrome (MERS). Read More

Review examines the extent of antimicrobial resistance in bacteria from horses

Bacterial resistance to antimicrobial agents is a significant problem for both human and veterinary medicine, but little research has been done on the prevalence or mechanisms of resistance in horses and other companion animals, and how such resistance might impact human health. Read More

Cockroach Caca Contains Chemical Messages Made by Microbes

Microbes play a huge role in our nutrition, our immunity, maybe even our mental health. But we aren’t the only ones that rely on these armies of resident bacteria. "Baby cockroaches, the ones that just emerge from the egg, don't have any gut bacteria." Coby Schal, an entomologist and chemical ec... Read More

UMMS scientists use CRISPR to discover Zika and dengue weaknesses

Scientists at the University of Massachusetts Medical School (UMMS) have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication. This work, led by Abraham Brass, MD, PhD, assistant professor in microbiology & physiological systems, reveals new lea... Read More

Public health concern as data reveals high prevalence of hepatitis B among refugees in Germany

April 16, 2016, Barcelona, Spain: A new study presented today demonstrates the potential challenge posed to public health systems across Europe as a result of the prevalence of Hepatitis B among new refugee populations. The study was presented at The International Liver Congress™ 2016 in Barcelo... Read More

Thrombosis during sepsis is a consequence of protective host immune responses

Researchers from the University of Birmingham have, for the first time, identified how Salmonella infections that have spread to our blood and organs can lead to life-threatening thrombosis. Read More

Young Inventors Work On Secret Proteins To Thwart Antibiotic-Resistant Bacteria

Three young inventors and students at Stanford University are working to develop proteins that fight antibiotic resistant bacteria. They are optimistic they have found something that works. The proteins the team is developing attack "something that's essential to bacterial survival". But they wo... Read More

Bacteria in Smokeless Tobacco Products May be a Health Concern

Washington, DC - August 26, 2016 - Several species of bacteria found in smokeless tobacco products have been associated with opportunistic infections, according to a paper published August 25 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. Read More

MMP #15: A Scientific Roadmap for Antibiotic Discovery

Host: Jeff Fox with special guests, Carolyn Shore and Ruben Tommasi.

Carolyn Shore of Pew Charitable Trusts in Washington, D.C., and Ruben Tommasi of Entasis Therapeutics in Waltham, Massachusetts, talk with Jeff Fox about what’s needed to identify and develop new antimicrobial agents... Read More

Getting closer to understanding Zika virus, one genome at a time

Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More

Cyclic-di-GMP takes center stage

How does a single-celled organism ‘know’ how to respond to its environmental conditions? Understanding microbial cell signaling is one way to determine how bacteria will react in a particular setting. In the past decade, researchers have revealed a significant role for cyclic-di-GMP in bacterial... Read More
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