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Nibbled to Death: U.Va. Researchers Discover New Way Human Cells Are Killed

Researchers at the University of Virginia School of Medicine studying a potentially deadly parasitic infection have discovered a previously unknown way that human cells are killed, with the parasitic amoeba essentially nibbling cells to death – as a piranha might attack its prey.

Until now, r... Read More

A Letter to STC from Julian Davies

Bravo Randy Schekman!

I strongly support your comments on the tyranny of "impact factors" and I will be pleased to join in efforts to prevent the misuse of these ratings.

Impact Factors have become a symbol of terror for scientists in all disciplines and their use in promotion and other ... Read More

How do they make it work? Genomic Revelations on a Bacterial Consortium

Do you ever look at a couple and wonder… ‘Why are they together? What does X see in Y. I just don’t get it. Is X in it only for the money’? Who doesn’t at times ponder about such matters? There’s practically an entire economy based on it. However, you didn’t find this article while waiting to ... Read More

Natural History is Dying, and We Are All the Losers

A few weeks ago, I came across a new paper in BioScience called “Natural History’s Place in Science and Society” that contained the following graph.

On the right axis and indicated by the line surrounded by dots is the proportion of introductory biology texts devoted to natural history since ... Read More

The Result of the Microbiome Poll

What have we learned?

The various comments confirm that the term microbiome means different things to different people.

Lita points out that in the early days when HMP was formed, the NIH officially defined the human microbiome as “all of the microorganisms and their genes and genomes whic... Read More

Dairy scientist targets heat-resistant microbes

Corralling desperados with names like bacillus and paenibacillus will require ingenuity and an arsenal of weapons. These outlaws aren't rustling cattle—they're making milk sour and cheese soft and crumbly.

For more than a century, milk has been heated to kill any bacteria or pathogens that ca... Read More

The bug that lost a few genes to become Black Death

About 6,000 years ago, a bacterium underwent a few genetic changes. These allowed it to expand its habitat from the guts of mice to that of fleas. Such changes happen all the time, but in this particular instance the transformation eventually resulted in the Black Death that wiped out a third of... Read More

Rare byproduct of marine bacteria kills cancer cells by snipping their DNA

Yale University researchers have determined how a scarce molecule produced by marine bacteria can kill cancer cells, paving the way for the development of new, low-dose chemotherapies.

The molecule, lomaiviticin A, was previously shown to be lethal to cultured human cancer cells, but the mech... Read More

Malaria’s Clinical Symptoms Fade on Repeat Infections Due to Loss of Immune Cells

Children who repeatedly become infected with malaria often experience no clinical symptoms with these subsequent infections, and a team led by UC San Francisco researchers has discovered that this might be due at least in part to a depletion of specific types of immune cells.

Working in Ugand... Read More

From the archives: life at 90°C

Prokaryotes are by far the most successful superkingdom in terms of both biochemical diversity and the variety of environments conquered. Bacteria can be found living in all kinds of adverse conditions; from high alkaline lakes, to below freezing temperature, to hot volcanic vents which in some ... Read More

How a plant beckons the bacteria that will do it harm

A common plant puts out a welcome mat to bacteria seeking to invade, and scientists have discovered the mat's molecular mix. The study published this week in the Proceedings of the National Academy of Sciences reveals new targets during the battle between microbe and host that researchers can ex... Read More

Brewing yeasts reveal secrets of chromosomal warfare and dysfunction

Using two yeasts that have been used to brew tea and beer for centuries, researchers at Fred Hutchinson Cancer Research Center have revealed how reproductive barriers might rapidly arise to create species boundaries. Schizosaccharomyces pombe has been used to brew beer in Africa, whereas its clo... Read More

Research shows bacteria can combat dangerous gas leaks

Bacteria could mop up naturally-occurring and man-made leaks of natural gases before they are released into the atmosphere and cause global warming - according to new research from the University of East Anglia.

Findings published today in the journal Nature shows how a single bacterial strai... Read More

A Cheap, Promising Way to Filter Water: Through A Twig

One way to avoid getting sick while traveling is to only eat fruit that you peel yourself, since plants can filter out bacteria and prevent it from traveling throughout their tissues. Well, why not apply this principle to filtering water directly? A team of scientists have done just that, testi... Read More

Insight into pathogenic fungus

The fungal pathogen Candida albicans causes yeast infections, diaper rashes and oral thrush, and is the most common fungal pathogen to infect humans. Researchers have identified a protein that the fungus uses to defend itself against the human body. Another concern with the fungus is that it can... Read More

Six to Tango

One genome at a time can be exciting, but two even more so. I’m not entirely sure why this is, although it may explain our fascination with sex. And what if more than two entities were involved? What if the intimacy were not just between two individual organisms, but between a greater number of ... Read More

Retrospective, December 2013

We continue our semi-annual ritual and post this quick tour of our featured blog posts published since June 2013.

Evolution

Microbial ‘Starstuff’. Associate blogger Gemma Reguera tells us how the remnants of a dying star become transmuted into microbial stuff, including cellular structures... Read More

Nutrient-absorbing surface’s assembly revealed: study

Vanderbilt University researchers have now discovered how intestinal cells build this specialized structure, which is critical for absorbing nutrients and defending against pathogens. The findings, published April 10 in the journal Cell, reveal a role for adhesion molecules in brush border assem... Read More

Antibiotic resistance mechanisms of clinically important bacteria.

Antibiotic resistance mechanisms of clinically important bacteria. Read More

Printable Biotechnology

Cells, biological circuits, and individual biomolecules organize themselves and interact with the environment. Use of these capabilities in flexible and economically efficient biotechnological production systems is in the focus of the "Molecular Interaction Engineering" (MIE) project. It is the ... Read More

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