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Ebola Outbreak 2014 2015 by Dr. Fauci

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Sierra Leone: Ebola Trial Begins

An Ebola vaccine candidate that has been successful in non-human primates is being tested on volunteers in Sierra Leone this month, where two new cases were reported as of Monday. Read More

HOW ZINC ‘JAMS UP’ THESE DRUG-RESISTANT MICROBES

New research from the University of Queensland has shown how zinc "tricks" an essentialmManganese-transport protein of S. pneumoniae into a shape in which it can't accept manganese. It is known that manganese is essential for S. pneumoniae infection to occur, so this research offers a chance to... Read More

YOUR GUT NEEDS BACTERIA TO MAKE MORE SEROTONIN

A new study from CalTech suggests that serotonin levels may be regulated to some degree by the gut microbiome. Researchers are investigating the degree to which bacteria in the guts of mice are able to confer serotonin-dependent function in comparison to control, or "germ-free" mice. Further s... Read More

A “Polio Warrior” Recounts Decades of Struggle Toward Eradication

Science writer Maryn McKenna interviews John Sever, MD, PhD, former chief of infectious diseases at the National Institutes of Health and current vice-chairman of Rotary’s International PolioPlus Committee, about the early days of the polio struggle and the introduction of the polio vaccine.

... Read More

BacterioFiles 210 - Archaea Acquired Alternative Abilities

This episode: Genes taken from bacteria may have been important for the evolution of distinct groups of archaea!


(7.4 MB, 8 minutes)


Show notes: 
Read More

TWiV 332: Vanderbilt virology

Host: Vincent Racaniello


Guests: Seth BordensteinJames Crowe... Read More

A transmissible cancer of soft-shell clams

A leukemia-like cancer is killing soft-shell clams along the east coast of North America. The cancer is transmitted between animals in the ocean, and appears to have originated in a single clam as recently as 40 years ago. Read More

Can Humans Get Norovirus From Their Dogs?

Human norovirus may infect our canine companions, according to research published online April 1 in the Journal of Clinical Microbiology, a publication of the American Society for Microbiology. That raises the possibility of dog-to-human transmission, said first author Sarah Caddy, VetMB, PhD, M... Read More

NIH funds 9 antimicrobial resistance diagnostics projects

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded more than $11 million in first-year funding for nine research projects supporting enhanced diagnostics to rapidly detect antimicrobial-resistant bacteria. The awardee institu... Read More

Anti-HIV antibody shows promise in first human study

A single infusion of an experimental anti-HIV antibody called 3BNC117 resulted in significantly decreased HIV levels that persisted for as long as 28 days in HIV-infected individuals, according to Phase 1 clinical trial findings published online today in Nature. Read More

CRISPR-Cas editing of C. albicans holds promise for overcoming deadly fungal infections

CAMBRIDGE, Mass. (April 3, 2015) - By modifying the CRISPR-Cas genome editing system, Whitehead Institute researchers are now able to manipulate Candida albicans' genome systematically--an approach that could help identify novel targets for therapies against this serious pathogen for which there... Read More

Pictures Considered #25. Getting A Ride

From Moselio Shaechter of ASM's Small Things Considered:

"A recent review article deals with the fascinating phenomenon of pathogens exiting from their host cell. Sometimes, one pathogen helps another one in transmission to the next host. In one case, a Candida albicans hypha caught in the ac... Read More

Gene variant and environment can boost severity of respiratory syncytial virus

A study published in the Journal of Clinical Investigation suggests that environmental factors, in conjunction with a mutation of the TLR4 gene, may contribute to the severity of RSV-related respiratory illness in children. TLR4 is a gene involved in the innate immune response, and investigator... Read More

New mechanisms of 'social networking' in bacteria

AMHERST, Mass. - Bacteria have traditionally been viewed as solitary organisms that "hang out on their own," says molecular biologist Kevin Griffith of the University of Massachusetts Amherst. However, scientists now realize that in fact, bacteria exhibit social behavior within groups. Read More

Yes, We Were Warned About Ebola

"The conventional wisdom among public health authorities is that the Ebola virus, which killed at least 10,000 people in Liberia, Sierra Leone and Guinea, was a new phenomenon, not seen in West Africa before 2013. (The one exception was an anomalous case in Ivory Coast in 1994, when a Swiss prim... Read More

Purging a virus from organ transplants

Human cytomegalovirus (HCMV) is an extremely common virus, which as other members of the herpes virus family causes life-long infections in humans. Most individuals are exposed to HCMV during childhood, yet symptoms can be easily fought off by a healthy immune system. However, infections can be ... Read More

Race for Ebola vaccine heats up as cases slow

LAUSANNE, SWITZERLAND—As scientists and medical experts race to develop a vaccine to stop the spread of Ebola, there are concerns the window of opportunity may be closing. Read More

Three Roads to Cellular Compartments

In a recent post to ASM's blog Small Things Considered, Merry Youle writes a wonderful, sometimes thrilling description of the different forms of cellular compartments that have evolved over the last 4 billion years or so. From compartmentalized, lipid-bound membranes in eukaryotes to microcomp... Read More

BacterioFiles 209 - Myxococcus Menace Motivates Megastructures

This episode: Microbial predators in soil cause microbial prey to build fortifications!


(8.8 MB, 9.5 minutes)


Show notes: 
Journal Paper


Read More

Cold Spring Harbor Lab, Seeking Human Subjects, Teams Up With Hospital System

Some of the world’s finest scientists live in a former whaling village on the North Shore of Long Island, in a compound reminiscent of an army post.

In this pastoral setting, they have very self-consciously taken themselves out of the real world into a cerebral one, where they are searching f... Read More
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