This episode: Slime molds have special cells that capture and kill bacteria using traps made of DNA!
(11.2 MB, 12.25 minutes)
A popular antibiotic called rifampicin, used to treat tuberculosis, leprosy, and Legionnaire’s disease, is becoming less effective as the bacteria that cause the diseases develop more resistance.
One of the mechanisms leading to rifampicin’s resistance is the action of the enzyme Rifampicin m... Read More
Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as "the molecular kiss of death". Tim Clausen's group at the Research Institute of Molecular Pathology (IMP) in Vienna identified an analo... Read More
Earlier this week, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his work on the underlying mechanisms of autophagy—the process by which cells break down and recycle their own contents. How does autophagy work? Here are the basics, as drawn for the article “How ... Read More
Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.
There is a growing popular and policy interest in the microbiome, and the possibilities of more nuanced or ‘probiotic’ ways of living with germs. To date however there has been limited public engagement with the science and technology of metagenomics. The project engages with the growing scienti... Read More
The natural presence of fatty acids in the human body leads to increased resistance of Staphylococcus aureus to a class of antimicrobials that target bacterial fatty acid biosynthesis. This discovery, based on research by INRA scientists in collaboration with with INSERM, Hôpital Cochin APHP, th... Read More
Colostrum is a thick, sticky, yellowish mammary secretion that all mammals provide to their newborns during the first 24-48 hours after delivery.
It has been reported that constituents from BC are 100-fold to 1,000-fold more potent than human colostrum. This means that even human infants can ... Read More
A new tool that uses a forest-like array of vertically-aligned carbon nanotubes that can be finely tuned to selectively trap viruses by their size can increase the detection threshold for viruses and speed the process of identifying newly-emerging viruses.
"Early detection is important becau... Read More
Researchers have discovered the strongest evidence yet linking the Zika virus to the paralytic illness Guillain-Barre syndrome. During the height of the viral epidemic the incidence of Guillain-Barre was 100 times the number of cases usually seen.
Guillain-Barre is a normally rare condition t... Read More
Laboratory tests show that a cold-tolerant mosquito known as Culex quinquefasciatus can be infected with Zika virus in the laboratory. If confirmed in the field, it would be a troubling development, suggesting the virus would be more difficult to control, and might be able to spread far north of... Read More
Dengue fever infects 390 million people each year, and kills as many as 25,000, according to the World Health Organization.
The disease could soon see these numbers decline as the Philippines start administering the world's first dengue vaccine to high-risk children.
The historic drug took... Read More
The TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls.
Humans have used Saccharomyces cerevisiae yeast in baking, brewing and winemaking for millennia. New research from the University of Idaho and the University of Colorado Boulder reveals another way that yeast species can help our species: by demonstrating how viruses interact with their hosts, a... Read More
Microbes are excellent at adapting to stressful situations, which is part of the reason antibiotic resistance is a problem today. Constant exposure to antimicrobials such as triclosan have selected for resistant strains, rendering the compound ineffective. This is why the FDA recently banned t... Read More
The night after receiving the news about winning the 2016 Nobel Prize in Physiology or Medicine, microbiologist Yoshinori Ohsumi expressed his eagerness to build a new research center for microbiology and create a system for supporting young scientists.
"Microorganisms support the living worl... Read More
A new 3-D printed, easily assembled smartphone microscope developed at Stanford University turns microbiology into game time. The device allows kids to play games or make more serious observations with miniature light-seeking microbes called Euglena.
When it’s assembled, it has a platform for... Read More
In an attempt to preserve and defend the good name of the salmon fished in his state, Senator Warren Magnuson (D-WA), introduced in 1969 a bill in the US Senate proposing to change the name of Salmonella to the more inoccuous sounding Sanella. In some circles it may seem comforting to th... Read More
Caenorhabditis elegans (often abbreviated C. elegans) is a roundworm (nematode) used as a model system not only to study human diseases but also for understanding fundamental biological processes.
"Now we know that Caenorhabditis elegans do have the ability to produce chondroitin sulfate. Th... Read More
Two vaccines against Zika virus developed at the University of Pittsburgh School of Medicine have successfully conveyed immunity from female mice to pups conceived weeks after the mother's vaccination.
When challenged with Zika virus within a week of their birth, both vaccines protected the p... Read More