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BacterioFiles 201 - Plastic-Producing Prokaryote Process

This episode: Bacteria from wastewater treatment sludge can produce lots of biodegradable plastic!


(7.1 MB, 7.75 minutes)


Show notes: 
Jour... Read More

'Virtual virus' unfolds the flu on a CPU

Combining experimental data from X-ray crystallography, NMR spectroscopy, cryoelectron microscopy and lipidomics, researchers have built a complete model of the outer envelope of an influenza A virion for the first time. The approach, known as a coarse-grained molecular dynamics simulation, has ... Read More

Bacteria's hidden traffic control

Not unlike an urban restaurant, the success of a bacterial cell depends on three things: localization, localization and localization. But the complete set of controls by which bacteria control the movement of proteins and other essential biological materials globally within the confines of their... Read More

In Treating Ebola, Even Using a Stethoscope Becomes a Challenge

Doctors treating Ebola patients while wearing “the full spacesuit” — protective gear, including waterproof hoods — are struggling with a clinician’s dilemma: what to do if they can’t use one of the oldest, most basic tools in medicine — a stethoscope.

It’s not safe to cut holes in the hood, a... Read More

TWiV 323: A skid loader full of viromes

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Read More

PhatoMap of New York Subway System

The microbes that call the New York City subway system home are mostly harmless, but include samples of disease-causing bacteria that are resistant to drugs — and even DNA fragments associated with anthrax and Bubonic plague — according to a citywide microbiome map published today by Weill Corne... Read More

Researchers find link between microbiome, type 1 diabetes

In the largest longitudinal study of the microbiome to date, researchers from the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and the DIABIMMUNE Study Group have identified a connection between changes in gut microbiota and the onset of type 1 diabetes (T1D). The st... Read More

Mosquitoes ramp up immune defenses after sucking blood

If you were about to enter a crowded subway during flu season, packed with people sneezing and coughing, wouldn't it be helpful if your immune system recognized the potentially risky situation and bolstered its defenses upon stepping into the train?

After ingesting a meal of blood, mosquitoes... Read More

TWiP 82: A NOD to helminths

Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice.


Hosts: Vincent Racaniello Read More

TWiP 82 letters


Allan writes:


Dear Vincent, Dickson and Daniel,


I like your idea of a TWIP coffee mug prize (or maybe a mug discount).


In this second case study you presented, the present symptoms are pretty vague, but his history is interesting. Also since with ... Read More

Researchers discover critical molecule in fight against lung infection

A Montana State University graduate student who wants to reduce the number of people dying from lung infections has discovered a molecule that's critical for immunity.

Caffrey researches the early immune response against Aspergillus fumigatus, a common mold that can be found in soil or compos... Read More

Study shows oysters, mussels have low levels of disease, parasites

NOAA's first-ever long-term report of the national distribution of parasites and disease in mussels and oysters, using data gathered between 1995 and 2009, provides a new data set for coastal resource management and shows the occurrence and severity of disease and parasite infections to be gener... Read More

Mapping the Bacteria in the NYC Subway (video)

For more than a year, Cornell University's Christopher Mason and his team of researchers have been identifying bacteria in the New York City subway system. And some of the findings might surprise you. Photo: Katie Orlinsky for The Wall Street Journal
Read More

Big Data and Bacteria: Mapping the New York Subway’s DNA

Aboard a No. 6 local train in Manhattan, Weill Cornell researcher Christopher Mason patiently rubbed a nylon swab back and forth along a metal handrail, collecting DNA in an effort to identify the bacteria in the New York City subway.

In 18 months of scouring the entire system, he has found g... Read More

Record Keeping Helps Bacteria’s Immune System Fight Invaders

Bacteria have a sophisticated means of defending themselves, and they need it: more viruses infect bacteria than any other biological entity.

Two experiments undertaken at the Department of Energy's SLAC National Accelerator Laboratory provide new insight at the heart of bacterial adaptive de... Read More

Lyme disease costs up to $1.3 billion per year to treat, study finds

Lyme disease, transmitted by a bite from a tick infected by the Borrelia burgdorferi bacteria, had long been considered easy to treat, usually requiring a single doctor's visit and a few weeks of antibiotics for most people.

But new research from the Johns Hopkins Bloomberg School of Public H... Read More

This Vitamin might protect kids from Malaria

Vitamin A may protect children against malaria, especially during the rainy season when infected mosquitos flourish, a study suggests.

“Our research found that children who received vitamin A supplementation were less likely to become infected with malaria,” she said. “Now we need to test vit... Read More

Global Fund Needed to Fight Dangerous Superbugs

A global fund should be created to speed development of much-needed new antibiotics to counter the growing threat of drug-resistant superbugs, a British-government backed review said on Thursday.

The review, headed by the leading economist and former Goldman Sachs chief Jim O'Neill, said far ... Read More

TWiM #97: There’s gold in them hills

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

TWiM 97 Letters


Dennis writes:
hi Doc,


A paper just published in nature:


http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14098.pdf


reports an effective antibiot... Read More

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