Remember Ebolaviruses? Many people are still working on vaccines and therapeutics. Here is a very nice story on a promising antiviral compound that is very effective at preventing disease in monkeys. But it doesn't work in mice - it's degraded. You know what they say - mice lie, monkeys exaggera... Read More
Washington, DC - March 1, 2016 - A new study suggests that the Middle East Respiratory Syndrome coronavirus (MERS-CoV) develops mutations that make the virus less virulent during an outbreak rather than more virulent. The study, published this week in mBio, an online open-access journal of the A... Read More
Evidence-based medicine is the approach used by doctors to make rational clinical decisions based on rigorous, well-controlled studies. By minimizing hunches, gut feelings, and anecdotal evidence, physicians and patients can follow recommendations that are most likely to have a positive outcome.... Read More
PITTSBURGH, March 2, 2016 - State laws mandating influenza immunization for people who work in health care increase their vaccination rates, according to new research led by the University of Pittsburgh School of Medicine. Read More
Vaccines are like pathogen imposters - they mimic these 'bad guys' in order to provoke a response from our immune systems, remove the invader and begin the healing process.
One of the key components in a vaccine is an adjuvant, which serves to enhance our body's immune response to vaccination... Read More
Lewis and Krithivasan Sankaranarayanan—“Krithi”-- both fro... Read More
In 2015, an unexpectedly large outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in South Korea had a disastrous impact on the whole country and highlighted scientists limited knowledge of this virus. Now, new research into this outbreak has revealed some very surprising findin... Read More
Oriol Sunyer, a professor at the University of Pennsylvania School of Veterinary Medicine, has described fish as "an open gut swimming." Their mucosal surfaces -- their skin, digestive tract and gills -- are in constant contact with water, including any pathogens that that water may contain. Read More
In Borneo, an island shared by Indonesia and Malaysia, some of the world’s oldest tropical forests are being cut down and replaced with oil palm plantations at a breakneck pace. Wiping forests high in biodiversity off the land for monoculture plantations causes numerous environmental problems, f... Read More
Antibiotics have proven to be a valuable weapon in the fight against infectious bacteria. However, due to the excess use of antibiotics in conventional treatments, overtime antibiotics have become less effective. Read More
High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyze in detail the infection mechanisms of coronaviruses. These viruses are notorious for attacking the respiratory tract of humans and animals. Read More
This episode: Gut microbes enhance the effectiveness of cancer therapies!
(10.7 MB, 11.7 minutes)
Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, who then discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis.
Hosts: Read More
One of the first challenges is in properly diagnosing Zika infection. Diagnosis is challenging for several reasons: first, many infected individuals don’t suffer severe symptoms. Those that do have relatively non-specific symptoms of low-grade fever, headaches, and muscle soreness that are somet... Read More
Understanding the scale and range of neurological disease associated with Zika virus infection is an urgent priority, warn researchers from the University of Liverpool's Institute of Infection and Global Health. Read More
Insecticide-treated nets may still help prevent malaria despite mosquitoes developing resistance, according to a new study published in Parasites & Vectors. Read More
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.
Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome. Read More
Greetings TWiM crew!
For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world's leading infectious cause of blindness, according to a study in Nature Communications. Read More