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Scripps Research Institute Scientists Reveal Weak Spots in Ebola’s Defenses

New Study Exposes How ZMapp Therapy Attacks Virus and Suggests Strategies to Improve It.

Scientists at The Scripps Research Institute (TSRI) have identified weak spots on the surface of Ebola virus that are targeted by the antibodies in ZMapp, the experimental drug cocktail administered to se... Read More

Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics

Bacteria in the GI tract fulfill many vital functions and are critical for digestion. Yet, these same bacteria can induce strong inflammatory responses by the immune system if they penetrate the gut and enter the bloodstream. Prior research has established the involvement of inflammatory process... Read More

Nobel Laureates and Ebola virus quarantine

After the governors of New York and New Jersey decided that health workers who have returned from the Ebola virus outbreak in West Africa should be subject to a 21-day quarantine, two Nobel laureates entered the fray. Bruce Beutler feels that the quarantine is the right thing to do, while Peter ... Read More

TWiP 79 letters


Jesse writes:


Doctors TWiP,


I came across this paper and thought it sounded interesting for a discussion on TWiP:


Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection
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How Bacteria In The Gut Help Fight Off Viruses

If it was a snake, it would have bitten us.

The secret to stopping a deadly stomach virus may be sitting right there in our guts, scientists reported Thursday in the journal Science. Or more specifically, the treatment is in our microbiome — the trillions of bacteria that inconspicuously hang... Read More

Contaminomics: Why Some Microbiome Studies May Be Wrong

You’ve got a group of people with a mysterious disease, and you suspect that some microbe might be responsible. You collect blood and tissue samples, you extract the DNA from them using a commonly used kit of chemicals, and you sequence the lot. Eureka! You find that every patient has the same m... Read More

VIBRIO CHOLERAE O1 ISOLATEDFROM HUMAN STOOL

THIS IS VIBRIO CHOLERAE O1 OGAWA ISOLATED FROM HUMAN STOOL SWAB PLATED ON BILE SALT AGAR Read More

UCI team develops test to rapidly diagnose bloodstream infection

New technology can detect bacterial invaders with unprecedented speed, sensitivity.

A new bloodstream infection test created by UC Irvine researchers can speed up diagnosis times with unprecedented accuracy, allowing physicians to treat patients with potentially deadly ailments more promptly... Read More

Single-dose, needle-free Ebola vaccine provides long-term protection in macaques

Scientists have demonstrated for the first time that a single-dose, needleless Ebola vaccine given to primates through their noses and lungs protected them against infection for at least 21 weeks. A vaccine that doesn’t require an injection could help prevent passing along infections through uni... Read More

An Ebola virus protein can cause massive inflammation and leaky blood vessels

Ebola GP protein covers the virus' surface and is shed from infected cells during infection. Shed GP can trigger massive dysregulation of the immune response and affect the permeability of blood vessels.

Click 'source" to read more. Read More

Our wine owes a debt to ancient viruses

Next time you pour a glass of wine, raise a toast to the 30-milion-year-old viruses that have contributed to the genetic make-up of modern grapes.

A team of UQ-led plant scientists has discovered that the Pinot Noir grape variety owes a significant part of its genetic heritage to ancient plan... Read More

Facets of the flu

Ebola has captured the attention of the world since the outbreak in West Africa began months ago, so far claiming more than 5,000 lives.

Closer to home, seasonal influenza is on its way. Aside from bringing brief misery to many, the flu leads to serious complications or even death for tens of... Read More

How cells defend themselves against antibiotics, cytostatic agents

ABC Transporters are proteins that are embedded in the cell membrane and facilitate the transport across cellular barriers not only of an almost unlimited variety of toxic substances, but also of substances that are essential for life. They also play a role in the development of antibiotic resis... Read More

New influenza virus affects cattle, pigs

A new influenza virus, discovered in pigs and later found in cows, shares common ancestry with known influenza viruses, but is distinct enough that researchers have proposed calling it Type D Influenza.

Click "source" to read more. Read More

Genetic tweak gave yellow fever mosquitoes a nose for human odor

One of the world’s deadliest mosquitoes sustains its taste for human blood thanks in part to a genetic tweak that makes it more sensitive to human odor, according to new research.

Researchers report in the journal Nature that the yellow fever mosquito contains a version of an odor-detecting g... Read More

New drug could make vaccines more effective in the elderly

Oxford University scientists have developed a new method of boosting the ageing immune system using a naturally occurring chemical compound.

Early tests in mice carried out by the research team have shown that the compound restores the immune system's inbuilt 'memory', enabling the body to mo... Read More

Here’s How Many Bacteria Spread Through One Kiss

First base is a great place to get your mouth microbes some new friends, finds a new study in the journal Microbiome. A ten-second French kiss can spread 80 million bacteria between mouths.

Study author Remco Kort, a professor and scientist at Netherlands Organisation for Applied Scientific R... Read More

New Tool Could Help Reshape the Limits of Synthetic Biology

Developed at NYU Langone Medical Center, the “telomerator” reshapes synthetic yeast chromosome into more flexible, realistic form, redefining what geneticists can build.

NYU Langone yeast geneticists report they have developed a novel tool — dubbed “the telomerator” — that could redefine the ... Read More

Line dancing bacteria on a chip (w/ Video)

By changing the direction of a magnetic field, so-called magneto-tactic bacteria are able to make a full U-turn. They can be taught line dancing in this way, inside the tiny micro channels of a lab on a chip. Magnetically steered objects will be capable of delivering medication, for example. Sci... Read More

Pre-symptomatic markers for hemorrhagic viruses like Ebola identified

It is possible to distinguish between different hemorrhagic fevers, including Marburg (Ebola cousin) and Lassa before the person becomes symptomatic, new research has found. This study will allow for the development of better diagnostics, especially during the early stages of disease, when treat... Read More
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