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MMP #15: A Scientific Roadmap for Antibiotic Discovery

Host: Jeff Fox with special guests, Carolyn Shore and Ruben Tommasi.

Carolyn Shore of Pew Charitable Trusts in Washington, D.C., and Ruben Tommasi of Entasis Therapeutics in Waltham, Massachusetts, talk with Jeff Fox about what’s needed to identify and develop new antimicrobial agents... Read More

TWiV Special: DA Henderson, smallpox eradicator

Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox era... Read More

Fungus causing fatal infections in hospitalized patients has unique growth patterns

One of the important tasks of Public Health England’s Mycology Reference Laboratory is to identify any newly emerging fungal pathogens that could become a public health risk. In recent months, the lab had tracked several clusters of Candida auris infections in British hospitals. The multidrug-re... Read More

Improving the quality of dairy products

Bitter tasting yogurt or cheese may not make it to your refrigerator, but it is produced and the result of pesky bacteria. The microbial composition of raw milk impacts the quality, shelf life, and safety of processed milk and other dairy products. Controlling the quality of these products is tr... Read More

Onward toward a Zika vaccine

On Monday, August 1, the US Centers for Disease Control and Prevention recommended that pregnant women not travel to Wynwood, a neighborhood north of downtown Miami, because health officials in Florida had found that mosquitoes there are actively transmitting Zika, a mosquito-borne virus that ca... Read More

TWiV 403: It's not easy being vaccine

The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, and a new adjuvanted subunit zoster vaccine.

Hosts:  Read More

BacterioFiles 264 - Small Cells Stimulate Satiety

This episode: Proteins from gut bacteria seems to affect hunger and satiety in their (rodent) hosts!

(7.7 MB, 8.3 minutes)

Show notes: 
Ne... Read More

TWiM #133: Right under our noses

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.

Hosts: Vincent Racaniello, Elio Schaechter, an... Read More

TWiM 133 Letters

Arthur writes:

Hello TWIMers!

I'm a graduate student working in mycoplasmology and I  must say I've been overjoyed to hear the past few episodes mention our tiny friends!

Elio's mention of their unique mechanism of moving ("Gliding Motility") made... Read More

Investigators Map Genomes of Three Historically Important Zika Strains

Washington, DC - August 18, 2016 - A team of researchers from Utah State University, Logan, has characterized the consensus genome sequences of three historically important Zika virus strains. This work is an important step towards developing antiviral therapeutic and preventive strategies again... Read More

Fungus Causing Fatal Infections in Hospitalized Patients Has Unique Growth Patterns

Washington, DC – August 17, 2016 – The multidrug-resistant yeast Candida auris, which has caused fatal infections in some hospitalized patients, has at least two different growth patterns and some of its strains are as capable of causing disease as the most invasive type of yeast called Candida ... Read More

THE RIDDLE OF THE R.I.D.L _ Zika virus Comics (Playlist)

In Zanzare, the new comic from Cimaza (www.cimazacomics.com/), we are plunged head-first into the global mystery of the Zika virus. We meet the mosquitoes (in Italian: zanzare) implicated in its spread; but the insects plead their innocence, saying it's all a misunderstanding. They lay their cas... Read More

Anti-Vax = Anti-Facts (Please Share)

"Hivi and his team of viruses (Ebola, Pox,..etc) believe they can win the battle, but the Virologists (who are real famous professors) beat them. However, new viruses pop-up, it will be a long battle. This makes the story very interesting and ever so engaging."

Drones transport microbiological samples without altering their content

Robots help sort patient samples, test clinical specimens, and analyze the results. Now a study shows that robots, in the form of drones, can help move our samples from place to place, with little effect on the analytical outcome.

Drone transport made a news splash when Amazon proposed using ... Read More

The Counterintuitive Way That Microbes Survive in Antarctica

A newly discovered microbe is changing the way scientists think about microbes in cold climates. Marinomonas primoryensis was found in Ace Lake, Antarctica, having attached itself to ice via antifreeze proteins. After a few experiments, scientists believe that M. primoryensis attaches to ice b... Read More

Mouse microbes may make scientific studies harder to replicate

The microbes that reside in mice are making it difficult to replicate scientific studies. Despite many researchers best efforts to standardize the environment and conditions that their mice live in, replication isn't always possible. While "cagemates" tend to have the same microbes in their gut,... Read More

An achilles heel for Clostridium difficile infections?

Clostridium difficile is a dangerous superbug. Infections with this bacterium can cause life-threatening diarrhea, and they are most likely to affect the elderly or people with health problems who spend a lot of time in hospitals (where C. difficile flourishes). The Centers for Disease Control a... Read More

Polio in Nigeria

Polio returns to Nigeria after two years - but it turns out it had never gone away.
Read More

For the First Time, Researchers Identify the Secret Genetic Weapon of Clostridium difficile

Washington, DC – August 16, 2016 – A trio of researchers at the University of Texas Health Science Center, School of Public Health in Houston, have identified the location of the genes that control production of toxins that harm people infected by Clostridium difficile bacteria. The gene locus, ... Read More

Microbial Identification and Tracking: the Next Generation

How do you identify an unknown microbe? If you’ve taken an introductory microbiology lab course in the past twenty years, chances are you were assigned an unknown bacterium that you had to identify through differential media and biochemical assays. Newer techniques like qPCR are being standardiz... Read More
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